Involvement of CYP4F2 in the Metabolism of a Novel Monophosphate Ester Prodrug of Gemcitabine and Its Interaction Potential In Vitro

The ProTide Prodrug Technology: From the Concept to the Clinic

(2017) Youcef Mehellou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Advanced Prodrug Strategies in Nucleoside and Non-Nucleoside Antiviral Agents: A Review of the Recent Five Years

(2017) et al.   MOLECULES

Recommendations for selecting drug-drug interactions for clinical decision support

(2016) H. Tilson et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Recent advances in drug delivery strategies for improved therapeutic efficacy of gemcitabine

(2016) Ravindra Dhar Dubey et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Enhanced Antitumor Activity of Monophosphate Ester Prodrugs of Gemcitabine: In Vitro and In Vivo Evaluation

(2016) Huixin Qi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Probing the Origins of Catalytic Discrimination between Phosphate and Sulfate Monoester Hydrolysis: Comparative Analysis of Alkaline Phosphatase and Protein Tyrosine Phosphatases

(2014) Logan D. Andrews et al.   BIOCHEMISTRY

Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals

(2014) Slobodan Rendic et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Phase I/II study of the pharmacokinetics, safety and antiretroviral activity of tenofovir alafenamide, a new prodrug of the HIV reverse transcriptase inhibitor tenofovir, in HIV-infected adults

(2014) M. Markowitz et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Application of ProTide Technology to Gemcitabine: A Successful Approach to Overcome the Key Cancer Resistance Mechanisms Leads to a New Agent (NUC-1031) in Clinical Development

(2014) Magdalena Slusarczyk et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cytochrome P450-Dependent Catabolism of Vitamin K: ω-Hydroxylation Catalyzed by Human CYP4F2 and CYP4F11

(2013) Katheryne Z. Edson et al.   BIOCHEMISTRY

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

(2013) Lars Petter Jordheim et al.   NATURE REVIEWS DRUG DISCOVERY

Preclinical Absorption, Distribution, Metabolism, and Excretion of an Oral Amide Prodrug of Gemcitabine Designed to Deliver Prolonged Systemic Exposure

(2013) Enaksha Wickremsinhe et al.   Pharmaceutics

Gemcitabine versus Modified Gemcitabine: A Review of Several Promising Chemical Modifications

(2012) Elodie Moysan et al.   MOLECULAR PHARMACEUTICS

CYP4F Enzymes Are Responsible for the Elimination of Fingolimod (FTY720), a Novel Treatment of Relapsing Multiple Sclerosis

(2010) Y. Jin et al.   DRUG METABOLISM AND DISPOSITION

Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

(2010) Eisuke Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

(2010) Michael J. Sofia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Gemcitabine chemoresistance in pancreatic cancer: Molecular mechanisms and potential solutions

(2009) Roland Andersson et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY