Advancing the Adverse Outcome Pathway for PPARγ Inactivation Leading to Pulmonary Fibrosis Using Bradford-Hill Consideration and the Comparative Toxicogenomics Database

Leveraging the Comparative Toxicogenomics Database to fill in knowledge gaps for environmental health: a test case for air pollution-induced cardiovascular disease

(2020) Allan Peter Davis et al.   TOXICOLOGICAL SCIENCES

A toxicity pathway-oriented approach to develop adverse outcome pathway: AHR activation as a case study

(2020) Yuan Jin et al.   ENVIRONMENTAL POLLUTION

Generating adverse outcome pathway (AOP) of inorganic arsenic-induced adult male reproductive impairment via integration of phenotypic analysis in comparative toxicogenomics database (CTD) and AOP wiki

(2020) Zili Chai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Development of Adverse Outcome Pathway for PPARγ antagonism leading to pulmonary fibrosis and chemical selection for its validation: ToxCast™ database and a deep learning artificial neural network model based approach

(2019) Jaeseong Jeong et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Therapeutic Targeting of Fibrotic Epithelial-Mesenchymal Transition–An Outstanding Challenge

(2019) Attila Fintha et al.   Frontiers in Pharmacology

Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions

(2019) Gregory S. Honda et al.   PLoS One

Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization

(2019) Katie Paul Friedman et al.   TOXICOLOGICAL SCIENCES

Deciphering Adverse Outcome Pathway Network Linked to Bisphenol F Using Text Mining and Systems Toxicology Approaches

(2019) Marylène Rugard et al.   TOXICOLOGICAL SCIENCES

Antagonizing peroxisome proliferator-activated receptor γ facilitates M1-to-M2 shift of microglia by enhancing autophagy via the LKB1-AMPK signaling pathway

(2018) Juan Ji et al.   AGING CELL

Inflammation and fibrosis

(2018) Matthias Mack   MATRIX BIOLOGY

Chemical-Induced Phenotypes at CTD Help Inform the Predisease State and Construct Adverse Outcome Pathways

(2018) Allan Peter Davis et al.   TOXICOLOGICAL SCIENCES

FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts

(2018) Markaisa Black et al.   Cell Reports

The Comparative Toxicogenomics Database: update 2019

(2018) Allan Peter Davis et al.   NUCLEIC ACIDS RESEARCH

Role of MicroRNAs in TGF-β Signaling Pathway-Mediated Pulmonary Fibrosis

(2017) Hara Kang   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

EMT and inflammation: inseparable actors of cancer progression

(2017) Meggy Suarez-Carmona et al.   Molecular Oncology

How well can carcinogenicity be predicted by high throughput “characteristics of carcinogens” mechanistic data?

(2017) Richard A. Becker et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Meprin β contributes to collagen deposition in lung fibrosis

(2017) V. Biasin et al.   Scientific Reports

Epithelial-mesenchymal transition in tissue repair and fibrosis

(2016) Rivka C. Stone et al.   CELL AND TISSUE RESEARCH

Significance of alpha smooth muscle actin expression in traumatic painful neuromas: a pilot study in rats

(2016) Weidong Weng et al.   Scientific Reports

Mechanisms of TGFβ-Induced Epithelial–Mesenchymal Transition

(2016) Aristidis Moustakas et al.   Journal of Clinical Medicine

Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: I. Challenges and research needs in ecotoxicology

(2015) Ksenia J. Groh et al.   CHEMOSPHERE

PPARγ activation following apoptotic cell instillation promotes resolution of lung inflammation and fibrosis via regulation of efferocytosis and proresolving cytokines

(2015) Y-S Yoon et al.   Mucosal Immunology

Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence

(2015) Richard A. Becker et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

The Role of PPAR Gamma in Systemic Sclerosis

(2015) Andréa Tavares Dantas et al.   PPAR Research

Diverse functions of matrix metalloproteinases during fibrosis

(2014) M. Giannandrea et al.   Disease Models & Mechanisms

Effect of pirfenidone on proliferation, TGF-β-induced myofibroblast differentiation and fibrogenic activity of primary human lung fibroblasts

(2014) Enrico Conte et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

(2014) Daniel L. Villeneuve et al.   TOXICOLOGICAL SCIENCES

Adverse Outcome Pathway Development II: Best Practices

(2014) Daniel L. Villeneuve et al.   TOXICOLOGICAL SCIENCES

Epithelial-to-mesenchymal transition in fibrosis: Collagen type I expression is highly upregulated after EMT, but does not contribute to collagen deposition

(2013) Nynke A. Hosper et al.   EXPERIMENTAL CELL RESEARCH

Myofibroblast Differentiation and Enhanced Tgf-B Signaling in Cystic Fibrosis Lung Disease

(2013) William T. Harris et al.   PLoS One

Organ fibrosis inhibited by blocking transforming growth factor-β signaling via peroxisome proliferator-activated receptor γ agonists

(2012) Yi-Lei Deng et al.   Hepatobiliary & Pancreatic Diseases International

Emerging PPARγ-Independent Role of PPARγLigands in Lung Diseases

(2012) Ajit A. Kulkarni et al.   PPAR Research

Regulation of Transforming Growth Factor-β1–driven Lung Fibrosis by Galectin-3

(2011) Alison C. MacKinnon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TGF-β signaling in fibrosis

(2011) Anna Biernacka et al.   GROWTH FACTORS

PPAR-γ Ligands Repress TGFβ-Induced Myofibroblast Differentiation by Targeting the PI3K/Akt Pathway: Implications for Therapy of Fibrosis

(2011) Ajit A. Kulkarni et al.   PLoS One

Pulmonary Fibrosis in Response to Environmental Cues and Molecular Targets Involved in Its Pathogenesis

(2011) Toshinori Yoshida et al.   Journal of Toxicologic Pathology

Epithelial to Mesenchymal Transition in Human Skin Wound Healing Is Induced by Tumor Necrosis Factor-α through Bone Morphogenic Protein-2

(2010) Chunli Yan et al.   AMERICAN JOURNAL OF PATHOLOGY

Anti-inflammatory Effects of Thiazolidinediones in Human Airway Smooth Muscle Cells

(2010) Ming Zhu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Rosiglitazone inhibits migration, proliferation, and phenotypic differentiation in cultured human lung fibroblasts

(2010) Qing Lin et al.   EXPERIMENTAL LUNG RESEARCH

TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P

(2010) Lynne A. Murray et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Identification of Epithelial to Mesenchymal Transition as a Novel Source of Fibroblasts in Intestinal Fibrosis

(2010) Sarah N. Flier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rosiglitazone Abrogates Bleomycin-Induced Scleroderma and Blocks Profibrotic Responses Through Peroxisome Proliferator-Activated Receptor-γ

(2009) Minghua Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

TGF-β-induced epithelial to mesenchymal transition

(2009) Jian Xu et al.   CELL RESEARCH

Mechanisms of the epithelial–mesenchymal transition by TGF-β

(2009) Michael K Wendt et al.   Future Oncology

Peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist inhibits transforming growth factor-beta1 and matrix production in human dermal fibroblasts

(2009) Guo-You Zhang et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-γ

(2008) Asish K Ghosh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pioglitazone, a Peroxisome Proliferator-Activated Receptor Gamma Ligand, Suppresses Bleomycin-Induced Acute Lung Injury and Fibrosis

(2008) Yasuhiro Aoki et al.   RESPIRATION

PPAR-γ agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis

(2007) Jami E. Milam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY