Article
Biochemistry & Molecular Biology
Hui Xia, Jinsong Song, Changfan Li, Feng Xue
Summary: Biocatalytic promiscuity, a rapidly developing field in biochemistry, offers an alternative strategy for the formation of C-N bonds, which are crucial for the production of various pharmaceuticals and agrochemicals. This review focuses on recent progress in utilizing promiscuous enzymes for constructing C-N bonds.
BIOORGANIC CHEMISTRY
(2022)
Review
Chemistry, Organic
Shuangqiu Gao, Lili Shi, Le Chang, Binglin Wang, Junkai Fu
Summary: The Mizoroki-Heck reaction is a widely used method for constructing C-C bonds, focusing on activated olefins and aryl/vinyl (pseudo) halides. In recent years, there has been growing interest in using unactivated alkenes and alkyl electrophiles in Heck-type reactions, leading to significant breakthroughs in this field.
SYNTHESIS-STUTTGART
(2021)
Review
Chemistry, Multidisciplinary
Yan-Nan Zheng, Hongxing Zheng, Ting Li, Wen-Ting Wei
Summary: C-N bonds are widely present in organic materials, natural products, pharmaceutical compounds, and agricultural chemicals. The development of greener and more convenient ways to form C-N bonds, particularly in late-stage synthesis, has become a hot research topic in synthetic chemistry. Copper-catalyzed radical reactions involving N-centered radicals are considered as a sustainable and promising approach for building C-N bonds.
Article
Chemistry, Multidisciplinary
Kirstin Scherlach, Wolfgang Kuttenlochner, Daniel H. Scharf, Axel A. Brakhage, Christian Hertweck, Michael Groll, Eva M. Huber
Summary: This study reveals the mechanism by which the human pathogenic fungus Aspergillus fumigatus incorporates two sulfur atoms into its virulence factor through a specific GST GliG. The structures of GliG with glutathione and its reaction product shed light on the stepwise processing of Phe and Ser moieties in gliotoxin biosynthesis. Enzymatic C-S bond formation in gliotoxin and related natural compounds is further elucidated through activity assays with mutants.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Organic
Vakhid A. Mamedov, Nataliya A. Zhukova
Summary: Benzimidazole is an important heterocycle widely researched and utilized by the pharmaceutical industry, known for its wide-ranging bioactivities and the ability to synthesize derivatives under environmentally benign conditions.
SYNTHESIS-STUTTGART
(2021)
Review
Chemistry, Organic
Baosheng Wei, Paul Knochel
Summary: Cross-couplings involving organozinc reagents can proceed well in the absence of transition-metal catalysts with reactive electrophiles. Highly diastereoselective and enantioselective cross-couplings can be readily performed with room-temperature configurationally stable alkylzinc species, producing diastereoselectively and enantiomerically enriched products. Highly regioselective magnesiations of functionalized arenes and heteroarenes undergo Negishi or Cu-catalyzed cross-couplings.
SYNTHESIS-STUTTGART
(2022)
Review
Chemistry, Organic
Bo Dong, Jian Shen, Lan-Gui Xie
Summary: Alkenes and alkynes are important compounds in various industries. The functionalization of these compounds to form carbon-sulfur bonds provides a versatile route to synthesize sulfur-containing compounds. This review summarizes recent progress in this area, divided into different catalytic processes.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Review
Chemistry, Multidisciplinary
Yong Yuan, Jie Yang, Aiwen Lei
Summary: Oxidative cross-coupling is a robust method for forming C-C, C-X, and X-Y bonds. Organic electrosynthesis is recognized as an environmentally friendly and powerful synthetic platform. Recent advancements have shown that radical-involved electrochemical oxidative cross-coupling reactions can be achieved under exogenous-oxidant-free conditions.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Chemistry, Organic
Surendran Amrutha, Sankaran Radhika, Gopinathan Anilkumar
Summary: Iron-and cobalt-catalyzed Sonogashira coupling reactions have been extensively studied in organic synthesis. Green and nanoparticle protocols have emerged in the past decades due to their significance in carbon-carbon bond formation. The non-toxic and inexpensive nature of the catalysts has gained considerable attention. This review comprehensively explores and compares the catalytic nature and activity of iron and cobalt catalysts in Sonogashira coupling reactions, with a particular emphasis on green strategies.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Chemistry, Applied
Rashid Ali, Rafia Siddiqui
Summary: The research explores the advancements in the activation/functionalization of inert C-H bonds, with significant progress made in ortho- and para-C-H bonds functionalization. However, the field of distal meta-C-H activation/functionalization is still in its infancy and requires further exploration and development. This review aims to raise awareness about the current status and potential future directions of meta-C-H functionalization research.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Organic
Jieun Jung, Susumu Saito
Summary: This article highlights the recent advances in using photocatalytic technology to convert carbon dioxide into organic molecules, including dual catalysis using visible-light photoredox/transition-metal catalysts or photoredox catalysts.
SYNTHESIS-STUTTGART
(2021)
Article
Chemistry, Multidisciplinary
Liyan Fu, Qiang Chen, Yasushi Nishihara
Summary: This paper reviews recent developments in cross-coupling reactions forming C-C bonds by cleaving C(sp(2))-F bonds, including conventional activation and decarbonylative or carbonyl-retentive methods. New protocols for forming various C-C bonds via transition-metal-catalyzed cleavage of C(sp(2))-F bonds are described.
Review
Chemistry, Multidisciplinary
Rui Zhang, Chang-Yang Song, Zhe Sui, Ye Yuan, Yu-Cheng Gu, Cheng Chen
Summary: Carbon-heteroatom bond formation without transition metals is a powerful synthetic method for efficiently synthesizing valuable molecules. This review presents selected examples and discusses the construction of C-N (including amination and amidation) and C-O (including etherification and hydroxylation) bonds under transition-metal free conditions. The involved catalysts/promoters, substrate scope, potential applications, and reaction mechanisms are systematically discussed.
Review
Biochemistry & Molecular Biology
Tse-Wei Chen, Palraj Kalimuthu, Pitchaimani Veerakumar, King-Chuen Lin, Shen-Ming Chen, Rasu Ramachandran, Vinitha Mariyappan, Selvam Chitra
Summary: Carbon-based nanocomposites have become the most promising materials in nanoscience and technology. They possess unique physical and chemical characteristics and are widely used in catalysts, sensors, and energy storage devices. This study focuses on the application of various carbon nanomaterials in the development of hydrogen fuel cells and discusses the principles, reaction mechanisms, and challenges of fuel cell technology.
Review
Chemistry, Physical
Hang Luo, Yunhui Feng, Luqing Lin
Summary: This review focuses on the discussion of variant nickel(II) complexes as precatalysts for forging diverse carbon-heteroatom bonds under visible-light irradiation in the absence of exogenous photocatalysts. Summary of photoactive nickel catalysis aims to promote the development of cheap, abundant metals catalyzed carbon-heteroatom couplings for efficient preparation of highly valuable chemicals.
Review
Chemistry, Multidisciplinary
Yuhong Wang, Yiming Li, Xuefeng Jiang
CHEMISTRY-AN ASIAN JOURNAL
(2018)
Article
Chemistry, Multidisciplinary
Jiaoyan Zhao, Xuefeng Jiang
CHINESE CHEMICAL LETTERS
(2018)
Article
Chemistry, Multidisciplinary
Shihao Chen, Ming Wang, Xuefeng Jiang
CHINESE JOURNAL OF CHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Xiao Xiao, Jiahui Xue, Xuefeng Jiang
NATURE COMMUNICATIONS
(2018)
Article
Chemistry, Organic
Wei Tan, Cuihong Wang, Xuefeng Jiang
ORGANIC CHEMISTRY FRONTIERS
(2018)
Review
Chemistry, Multidisciplinary
Ming Wang, Xuefeng Jiang
TOPICS IN CURRENT CHEMISTRY
(2018)
Article
Chemistry, Organic
Ming Wang, Zongjun Qiao, Jiaoyan Zhao, Xuefeng Jiang
Article
Chemistry, Multidisciplinary
Ming Wang, Jiaoyan Zhao, Xuefeng Jiang
Article
Chemistry, Multidisciplinary
Yiming Li, S. Aal-e-Ali Rizvi, Deqing Hu, Danwen Sun, Anhui Gao, Yubo Zhou, Jia Li, Xuefeng Jiang
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Chemistry, Organic
Wei Tan, Niklas Jaensch, Tina Oehlmann, Franz-Josef Meyer-Almes, Xuefeng Jiang
Article
Chemistry, Multidisciplinary
Yingying Meng, Ming Wang, Xuefeng Jiang
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Review
Biochemistry & Molecular Biology
Nengzhong Wang, Puli Saidhareddy, Xuefeng Jiang
NATURAL PRODUCT REPORTS
(2020)
Article
Chemistry, Multidisciplinary
Shihao Chen, Yaping Li, Ming Wang, Xuefeng Jiang
Article
Chemistry, Multidisciplinary
Yiming Li, Tao Mou, Lingling Lu, Xuefeng Jiang
CHEMICAL COMMUNICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Ming Wang, Qiaoling Fan, Xuefeng Jiang
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
