Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats

Non-SUMOylated CRMP2 decreases NaV1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15

(2021) Kimberly Gomez et al.   Molecular Brain

The physiological function of different voltage-gated sodium channels in pain

(2021) George Goodwin et al.   NATURE REVIEWS NEUROSCIENCE

Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents

(2021) Song Cai et al.   Science Translational Medicine

Coordinating Synaptic Signaling with CRMP2

(2020) Harrison Stratton et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific NaV1.7 regulation in the pathogenesis of chronic neuropathic pain

(2020) Aubin Moutal et al.   PAIN

Differential expression of Cdk5-phosphorylated CRMP2 following a spared nerve injury

(2020) Aubin Moutal et al.   Molecular Brain

CRMP2-derived peptide ST2-104 (R9-CBD3) protects SH-SY5Y neuroblastoma cells against Aβ25-35-induced neurotoxicity by inhibiting the pCRMP2/NMDAR2B signaling pathway

(2019) Yingshi Ji et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Mining the Nav1.7 interactome: Opportunities for chronic pain therapeutics

(2019) Lindsey A. Chew et al.   BIOCHEMICAL PHARMACOLOGY

AAV-encoded CaV2.2 peptide aptamer CBD3A6K for primary sensory neuron-targeted treatment of established neuropathic pain

(2019) Hongwei Yu et al.   GENE THERAPY

Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking

(2019) William C. Buchta et al.   MOLECULAR NEUROBIOLOGY

Sham surgeries for central and peripheral neural injuries persistently enhance pain-avoidance behavior as revealed by an operant conflict test

(2019) Max A. Odem et al.   PAIN

Lack of Detection of the Analgesic Properties of PF‐05089771, a Selective Na v 1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects

(2019) Pieter Siebenga et al.   CTS-Clinical and Translational Science

Oral Dimethyl Fumarate Reduces Peripheral Neuropathic Pain in Rodents via NFE2L2 Antioxidant Signaling

(2019) Jiahe Li et al.   ANESTHESIOLOGY

TNF-α mediated upregulation of NaV1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation

(2019) Flávio Henrique Pequeno de Macedo et al.   Molecular Brain

DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats

(2018) Peter M. Grace et al.   EXPERIMENTAL NEUROLOGY

CRMP2–Neurofibromin Interface Drives NF1-related Pain

(2018) Aubin Moutal et al.   NEUROSCIENCE

Inhibition of the Ubc9 E2 SUMO-conjugating enzyme–CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain

(2018) Liberty François-Moutal et al.   PAIN

Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels

(2018) Liberty François-Moutal et al.   Channels

Phosphorylated CRMP2 Regulates Spinal Nociceptive Neurotransmission

(2018) Jie Yu et al.   MOLECULAR NEUROBIOLOGY

Blocking CRMP2 SUMOylation reverses neuropathic pain

(2017) A Moutal et al.   MOLECULAR PSYCHIATRY

Dissecting the role of the CRMP2–neurofibromin complex on pain behaviors

(2017) Aubin Moutal et al.   PAIN

CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide

(2017) Aubin Moutal et al.   PAIN

(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology

(2016) Aubin Moutal et al.   PAIN

Hierarchical CRMP2 posttranslational modifications control NaV1.7 function

(2016) Erik T. Dustrude et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

(2016) Peter M. Grace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

(2016) Aristos J. Alexandrou et al.   PLoS One

(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5

(2015) Aubin Moutal et al.   MOLECULAR NEUROBIOLOGY

A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors

(2015) Liberty François-Moutal et al.   PAIN

Collapsin Response Mediator Protein 2 (CRMP2) Interacts withN-Methyl-d-aspartate (NMDA) Receptor and Na+/Ca2+Exchanger and Regulates Their Functional Activity

(2014) Tatiana Brustovetsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMOylation alters CRMP2 regulation of calcium influx in sensory neurons

(2013) Weina Ju et al.   Channels

CRMP2 Protein SUMOylation Modulates NaV1.7 Channel Trafficking

(2013) Erik T. Dustrude et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

(2013) K. McCormack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of NMDAR–CRMP-2 signaling protects against focal cerebral ischemic damage in the rat middle cerebral artery occlusion model

(2012) Joel M. Brittain et al.   Channels

Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2

(2012) Joel M. Brittain et al.   FEBS LETTERS

Inhibition of Transmitter Release and Attenuation of Anti-retroviral-associated and Tibial Nerve Injury-related Painful Peripheral Neuropathy by Novel Synthetic Ca2+Channel Peptides

(2012) Sarah M. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of pain-related behavior in two distinct rodent models of peripheral neuropathy by a homopolyarginine-conjugated CRMP2 peptide

(2012) Weina Ju et al.   JOURNAL OF NEUROCHEMISTRY

Expression of Nav1.7 in DRG Neurons Extends from Peripheral Terminals in the Skin to Central Preterminal Branches and Terminals in the Dorsal Horn

(2012) Joel A Black et al.   Molecular Pain

CRMP-2 Peptide Mediated Decrease of High and Low Voltage-Activated Calcium Channels, Attenuation of Nociceptor Excitability, and Anti-Nociception in a Model of AIDS Therapy-Induced Painful Peripheral Neuropathy

(2012) Andrew D Piekarz et al.   Molecular Pain

Delayed calcium dysregulation in neurons requires both the NMDA receptor and the reverse Na+/Ca2+ exchanger

(2012) Matthew K. Brittain et al.   NEUROBIOLOGY OF DISEASE

A peptide uncoupling CRMP-2 from the presynaptic Ca2+ channel complex demonstrates efficacy in animal models of migraine and AIDS therapy-induced neuropathy

(2012) Matthew Ripsch et al.   Translational Neuroscience

Predictive validity of behavioural animal models for chronic pain

(2011) Odd-Geir Berge   BRITISH JOURNAL OF PHARMACOLOGY

Neuroprotection against Traumatic Brain Injury by a Peptide Derived from the Collapsin Response Mediator Protein 2 (CRMP2)

(2011) Joel M. Brittain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex

(2011) Joel M Brittain et al.   NATURE MEDICINE

Thioredoxin Mediates Oxidation-Dependent Phosphorylation of CRMP2 and Growth Cone Collapse

(2011) A. Morinaka et al.   Science Signaling

Neuronal circuitry for pain processing in the dorsal horn

(2010) Andrew J. Todd   NATURE REVIEWS NEUROSCIENCE

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Semaphorin3A Signaling Mediated by Fyn-dependent Tyrosine Phosphorylation of Collapsin Response Mediator Protein 2 at Tyrosine 32

(2009) Yutaka Uchida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Collapsin Response Mediator Protein 2 on Tyr-479 Regulates CXCL12-induced T Lymphocyte Migration

(2009) Michel Varrin-Doyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY