(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5

Tau Phosphorylation by cdk5 and Fyn in Response to Amyloid Peptide Aβ25–35: Involvement of Lipid Rafts

(2017) Paula Hernandez et al.   JOURNAL OF ALZHEIMERS DISEASE

Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides

(2015) Aubin Moutal et al.   Frontiers in Cellular Neuroscience

Specific Binding of Lacosamide to Collapsin Response Mediator Protein 2 (CRMP2) and Direct Impairment of its Canonical Function: Implications for the Therapeutic Potential of Lacosamide

(2014) Sarah M. Wilson et al.   MOLECULAR NEUROBIOLOGY

CRMP2

(2014) Jacque P.K. Ip et al.   NEUROSCIENTIST

Differential regulation of collapsin response mediator protein 2 (CRMP2) phosphorylation by GSK3ß and CDK5 following traumatic brain injury

(2014) Sarah M. Wilson et al.   Frontiers in Cellular Neuroscience

The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth

(2014) Sarah M. Wilson et al.   Frontiers in Cellular Neuroscience

SUMOylation alters CRMP2 regulation of calcium influx in sensory neurons

(2013) Weina Ju et al.   Channels

Synergism of lacosamide with established antiepileptic drugs in the 6-Hz seizure model in mice

(2013) Alexey Shandra et al.   EPILEPSIA

CDK5, CRMP2 and NR2B in spinal dorsal horn and dorsal root ganglion have different role in pain signaling between neuropathic pain model and inflammatory pain model

(2013) Y. Kamiya et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Mapping CRMP3 domains involved in dendrite morphogenesis and voltage-gated calcium channel regulation

(2013) T. T. Quach et al.   JOURNAL OF CELL SCIENCE

GSK-3α/β-mediated phosphorylation of CRMP-2 regulates activity-dependent dendritic growth

(2013) Minghui Tan et al.   JOURNAL OF NEUROCHEMISTRY

Collapsin response mediator protein 2 is involved in regulating breast cancer progression

(2013) Kazuhiro Shimada et al.   Breast Cancer

CaV1 and CaV2 Channels Engage Distinct Modes of Ca2+ Signaling to Control CREB-Dependent Gene Expression

(2012) Damian G. Wheeler et al.   CELL

Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2

(2012) Joel M. Brittain et al.   FEBS LETTERS

Phosphorylated tubulin adaptor protein CRMP-2 as prognostic marker and candidate therapeutic target for NSCLC

(2012) Erik Oliemuller et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of Transmitter Release and Attenuation of Anti-retroviral-associated and Tibial Nerve Injury-related Painful Peripheral Neuropathy by Novel Synthetic Ca2+Channel Peptides

(2012) Sarah M. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of pain-related behavior in two distinct rodent models of peripheral neuropathy by a homopolyarginine-conjugated CRMP2 peptide

(2012) Weina Ju et al.   JOURNAL OF NEUROCHEMISTRY

Prevention of posttraumatic axon sprouting by blocking collapsin response mediator protein 2-mediated neurite outgrowth and tubulin polymerization

(2012) S.M. Wilson et al.   NEUROSCIENCE

Nonparametric Evaluation of Quantitative Traits in Population-Based Association Studies when the Genetic Model is Unknown

(2012) Frank Konietschke et al.   PLoS One

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Pharmacokinetics, brain distribution, and plasma protein binding of the antiepileptic drug lacosamide in rats

(2011) Tae-Sung Koo et al.   ARCHIVES OF PHARMACAL RESEARCH

ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation

(2011) Shuji Wakatsuki et al.   NATURE CELL BIOLOGY

Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex

(2011) Joel M Brittain et al.   NATURE MEDICINE

Formation of N-type (Cav2.2) voltage-gated calcium channel membrane microdomains: Lipid raft association and clustering

(2010) Philip Robinson et al.   CELL CALCIUM

In SilicoDocking and Electrophysiological Characterization of Lacosamide Binding Sites on Collapsin Response Mediator Protein-2 Identifies a Pocket Important in Modulating Sodium Channel Slow Inactivation

(2010) Yuying Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A High-Performance Liquid Chromatography Assay to Monitor the New Antiepileptic Drug Lacosamide in Patients With Epilepsy

(2010) Clare Greenaway et al.   THERAPEUTIC DRUG MONITORING

Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity

(2009) Young Chan Chae et al.   CELLULAR SIGNALLING

Characterization of the role of full-length CRMP3 and its calpain-cleaved product in inhibiting microtubule polymerization and neurite outgrowth

(2009) Amy Aylsworth et al.   EXPERIMENTAL CELL RESEARCH

An Atypical Role for Collapsin Response Mediator Protein 2 (CRMP-2) in Neurotransmitter Release via Interaction with Presynaptic Voltage-gated Calcium Channels

(2009) Joel M. Brittain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons

(2009) X. X. Chi et al.   JOURNAL OF CELL SCIENCE

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Numb-mediated neurite outgrowth is isoform-dependent, and requires activation of voltage-dependent calcium channels

(2009) C.B. Lu et al.   NEUROSCIENCE

Crystal and solution structure, stability and post-translational modifications of collapsin response mediator protein 2

(2008) Viivi Majava et al.   FEBS Journal

Relative Resistance of Cdk5-phosphorylated CRMP2 to Dephosphorylation

(2008) Adam R. Cole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Block of Sensory Neuronal Voltage-Gated Sodium Channels by Lacosamide [(2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide], Lidocaine, and Carbamazepine

(2008) P. L. Sheets et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS