Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types

IL‐34 reprograms glycolytic and osteoclastic RA macrophages via Syndecan‐1 and M‐CSFR

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Tofacitinib therapy intercepts macrophage metabolic reprogramming instigated by SARS‐CoV‐2 Spike protein

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IRAK4 inhibition: a promising strategy for treating RA joint inflammation and bone erosion

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IACS-010759, a potent inhibitor of glycolysis-deficient hypoxic tumor cells, inhibits mitochondrial respiratory complex I through a unique mechanism

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Proinflammatory profile of autoimmune CD8 + T cells relies on increased LDHA activity and aerobic glycolysis

(2020) M. Margarida Souto‐Carneiro et al.   Arthritis & Rheumatology

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(2020) Cornelia M. Weyand et al.   NATURE IMMUNOLOGY

N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation

(2019) Zhenke Wen et al.   NATURE IMMUNOLOGY

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

(2019) Fan Zhang et al.   NATURE IMMUNOLOGY

Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma

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Fibroblast-Like Synoviocytes Glucose Metabolism as a Therapeutic Target in Rheumatoid Arthritis

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JAK-STAT blockade alters synovial bioenergetics, mitochondrial function and pro-inflammatory mediators in Rheumatoid arthritis

(2018) Trudy McGarry et al.   Arthritis & Rheumatology

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Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis

(2018) Georges Abboud et al.   Frontiers in Immunology

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Differential impact of obesity on the pathogenesis of RA or preclinical models is contingent on the disease status

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Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

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Exenatide and metformin express their anti-inflammatory effects on human monocytes/macrophages by the attenuation of MAPKs and NFκB signaling

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Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

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Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

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Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression

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Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway

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AMPK Activation by A-769662 Controls IL-6 Expression in Inflammatory Arthritis

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The Monocarboxylate Transporter 4 Is Required for Glycolytic Reprogramming and Inflammatory Response in Macrophages

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Ligation of TLR5 Promotes Myeloid Cell Infiltration and Differentiation into Mature Osteoclasts in Rheumatoid Arthritis and Experimental Arthritis

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Angiogenesis in Rheumatoid Arthritis Is Fostered Directly by Toll-like Receptor 5 Ligation and Indirectly Through Interleukin-17 Induction

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Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

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The Novel Role of IL-7 Ligation to IL-7 Receptor in Myeloid Cells of Rheumatoid Arthritis and Collagen-Induced Arthritis

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PI3 Kinase δ Is a Key Regulator of Synoviocyte Function in Rheumatoid Arthritis

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Characterization of interleukin-7 and interleukin-7 receptor in the pathogenesis of rheumatoid arthritis

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Characterization of CCL19 and CCL21 in rheumatoid arthritis

(2011) Sarah R. Pickens et al.   ARTHRITIS AND RHEUMATISM

Local expression of interleukin-27 ameliorates collagen-induced arthritis

(2011) Sarah R. Pickens et al.   ARTHRITIS AND RHEUMATISM

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

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TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

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Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

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