IRAK4 inhibition: a promising strategy for treating RA joint inflammation and bone erosion
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Title
IRAK4 inhibition: a promising strategy for treating RA joint inflammation and bone erosion
Authors
Keywords
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Journal
Cellular & Molecular Immunology
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-05-15
DOI
10.1038/s41423-020-0433-8
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Note: Only part of the references are listed.- Macrophages are the primary effector cells in IL-7-induced arthritis
- (2019) Seung-jae Kim et al. Cellular & Molecular Immunology
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- (2019) Katrien Van Raemdonck et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Targeting IRAK4 disrupts inflammatory pathways and delays tumor development in chronic lymphocytic leukemia
- (2019) Neus Giménez et al. LEUKEMIA
- Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis
- (2019) Hideo Negishi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- IL-11 facilitates a novel connection between RA joint fibroblasts and endothelial cells
- (2018) Hatem A. Elshabrawy et al. ANGIOGENESIS
- Polymeric nanoparticles encapsulating novel TLR7/8 agonists as immunostimulatory adjuvants for enhanced cancer immunotherapy
- (2018) Hyunjoon Kim et al. BIOMATERIALS
- IRAK4 kinase activity controls Toll-like receptor–induced inflammation through the transcription factor IRF5 in primary human monocytes
- (2017) Leah Cushing et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy
- (2017) Jian Ye et al. JOURNAL OF IMMUNOLOGY
- Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design
- (2017) Katherine L. Lee et al. JOURNAL OF MEDICINAL CHEMISTRY
- The TLR7 agonist imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for melanoma
- (2017) Jeong Hyun Cho et al. Oncotarget
- A Brief History of IL-1 and IL-1 Ra in Rheumatology
- (2017) Jean-Michel Dayer et al. Frontiers in Pharmacology
- Differential impact of obesity on the pathogenesis of RA or preclinical models is contingent on the disease status
- (2016) Seung-jae Kim et al. ANNALS OF THE RHEUMATIC DISEASES
- TLR7 Engagement on Dendritic Cells Enhances Autoreactive Th17 Responses via Activation of ERK
- (2016) Qing Xiao et al. JOURNAL OF IMMUNOLOGY
- TLR7-based cancer immunotherapy decreases intratumoral myeloid-derived suppressor cells and blocks their immunosuppressive function
- (2016) Thibaud Spinetti et al. OncoImmunology
- Anti-Citrullinated Protein Antibodies Induce Macrophage Subset Disequilibrium in RA Patients
- (2015) Wei Zhu et al. INFLAMMATION
- IRF5 controls both acute and chronic inflammation
- (2015) Miriam Weiss et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model
- (2015) Pierre Duffau et al. Arthritis & Rheumatology
- Characterising the expression and function of CCL28 and its corresponding receptor, CCR10, in RA pathogenesis
- (2014) Zhenlong Chen et al. ANNALS OF THE RHEUMATIC DISEASES
- Interleukin 1/Toll-like Receptor-induced Autophosphorylation Activates Interleukin 1 Receptor-associated Kinase 4 and Controls Cytokine Induction in a Cell Type-specific Manner
- (2014) Leah Cushing et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ligation of TLR5 Promotes Myeloid Cell Infiltration and Differentiation into Mature Osteoclasts in Rheumatoid Arthritis and Experimental Arthritis
- (2014) Seung-jae Kim et al. JOURNAL OF IMMUNOLOGY
- Expression and Function of Aminopeptidase N/CD13 Produced by Fibroblast-like Synoviocytes in Rheumatoid Arthritis: Role of CD13 in Chemotaxis of Cytokine-Activated T Cells Independent of Enzymatic Activity
- (2014) Rachel Morgan et al. Arthritis & Rheumatology
- Angiogenesis in Rheumatoid Arthritis Is Fostered Directly by Toll-like Receptor 5 Ligation and Indirectly Through Interleukin-17 Induction
- (2013) Seung-jae Kim et al. ARTHRITIS AND RHEUMATISM
- A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice
- (2013) Fu-Gang Zhu et al. AUTOIMMUNITY
- The Novel Role of IL-7 Ligation to IL-7 Receptor in Myeloid Cells of Rheumatoid Arthritis and Collagen-Induced Arthritis
- (2013) Z. Chen et al. JOURNAL OF IMMUNOLOGY
- Suppression of Molecular Inflammatory Pathways by Toll-Like Receptor 7, 8, and 9 Antagonists in a Model of IL-23-Induced Skin Inflammation
- (2013) Mayte Suárez-Fariñas et al. PLoS One
- Interleukin-6 Receptor Blockade Enhances CD39+ Regulatory T Cell Development in Rheumatoid Arthritis and in Experimental Arthritis
- (2013) A. Thiolat et al. Arthritis & Rheumatology
- Ligation of TLR7 by rheumatoid arthritis synovial fluid single strand RNA induces transcription of TNFα in monocytes
- (2012) Nathan D Chamberlain et al. ANNALS OF THE RHEUMATIC DISEASES
- Incomplete response of inflammatory arthritis to TNFα blockade is associated with the Th17 pathway
- (2012) Saba Alzabin et al. ANNALS OF THE RHEUMATIC DISEASES
- Long-term amelioration of established collagen-induced arthritis achieved with short-term therapy combining anti-CD3 and anti-tumor necrosis factor treatments
- (2012) Fabien Dépis et al. ARTHRITIS AND RHEUMATISM
- R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts
- (2012) Arei Miyamoto et al. CYTOTECHNOLOGY
- TLR5, a Novel and Unidentified Inflammatory Mediator in Rheumatoid Arthritis that Correlates with Disease Activity Score and Joint TNF- Levels
- (2012) N. D. Chamberlain et al. JOURNAL OF IMMUNOLOGY
- MicroRNA-574-5p Was Pivotal for TLR9 Signaling Enhanced Tumor Progression via Down-Regulating Checkpoint Suppressor 1 in Human Lung Cancer
- (2012) Qinchuan Li et al. PLoS One
- Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance
- (2012) Saba Alzabin et al. ARTHRITIS RESEARCH & THERAPY
- Characterization of interleukin-7 and interleukin-7 receptor in the pathogenesis of rheumatoid arthritis
- (2011) Sarah R. Pickens et al. ARTHRITIS AND RHEUMATISM
- Characterization of CCL19 and CCL21 in rheumatoid arthritis
- (2011) Sarah R. Pickens et al. ARTHRITIS AND RHEUMATISM
- Local expression of interleukin-27 ameliorates collagen-induced arthritis
- (2011) Sarah R. Pickens et al. ARTHRITIS AND RHEUMATISM
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- Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells
- (2008) Clare A. Notley et al. JOURNAL OF EXPERIMENTAL MEDICINE
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