Sestrin2 protects against lethal sepsis by suppressing the pyroptosis of dendritic cells

An update on the regulatory mechanisms of NLRP3 inflammasome activation

(2021) Seungwha Paik et al.   Cellular & Molecular Immunology

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

(2021) Damien Bertheloot et al.   Cellular & Molecular Immunology

Sestrin2 protects dendritic cells against endoplasmic reticulum stress-related apoptosis induced by high mobility group box-1 protein

(2020) Li-Xue Wang et al.   Cell Death & Disease

Globular Adiponectin Inhibits Breast Cancer Cell Growth through Modulation of Inflammasome Activation: Critical Role of Sestrin2 and AMPK Signaling

(2020) Duc-Vinh Pham et al.   Cancers

Recombinant human ulinastatin improves immune dysfunction of dendritic cells in septic mice by inhibiting endoplasmic reticulum stress-related apoptosis

(2020) An-Long Qi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inflammasome activation: a monocyte lineage privilege

(2019) Pierre Guermonprez et al.   NATURE IMMUNOLOGY

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model

(2019) Ziv Erlich et al.   NATURE IMMUNOLOGY

Immune checkpoints and the regulation of tolerogenicity in dendritic cells: Implications for autoimmunity and immunotherapy

(2019) Samanta C. Funes et al.   AUTOIMMUNITY REVIEWS

Caspase-1 initiates apoptosis in the absence of gasdermin D

(2019) Kohsuke Tsuchiya et al.   Nature Communications

P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis

(2019) Juan José Martínez-García et al.   Nature Communications

Inflammasomes: Threat-Assessment Organelles of the Innate Immune System

(2019) Charles L. Evavold et al.   IMMUNITY

Prognostic and predictive enrichment in sepsis

(2019) Natalja L. Stanski et al.   Nature Reviews Nephrology

The NLRP3 Inflammasome and Its Role in Sepsis Development

(2019) Lucinéia Gainski Danielski et al.   INFLAMMATION

ER Stress Activates the NLRP3 Inflammasome: A Novel Mechanism of Atherosclerosis

(2019) Xinnong Chen et al.   Oxidative Medicine and Cellular Longevity

Sestrin2: Its Potential Role and Regulatory Mechanism in Host Immune Response in Diseases

(2019) Li-Xue Wang et al.   Frontiers in Immunology

Dendritic cells in sepsis: Potential immunoregulatory cells with therapeutic potential

(2018) V. Kumar   MOLECULAR IMMUNOLOGY

FXR Inhibits Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome in Hepatocytes and Ameliorates Liver Injury

(2018) Chang Yeob Han et al.   Cell Reports

Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway

(2017) Hyo Jeong Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Advances in the understanding and treatment of sepsis-induced immunosuppression

(2017) Fabienne Venet et al.   Nature Reviews Nephrology

Dendritic cells in host response to biologic scaffolds

(2017) Cynthia A. Leifer   SEMINARS IN IMMUNOLOGY

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

(2017) Robin A. Aglietti et al.   TRENDS IN IMMUNOLOGY

The involvement of endoplasmic reticulum stress response in immune dysfunction of dendritic cells after severe thermal injury in mice

(2017) Xiao-Mei Zhu et al.   Oncotarget

Persistent lymphopenia is a risk factor for ICU-acquired infections and for death in ICU patients with sustained hypotension at admission

(2017) Christophe Adrie et al.   Annals of Intensive Care

SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages

(2016) Min-Ji Kim et al.   Autophagy

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sepsis-induced immune dysfunction: can immune therapies reduce mortality?

(2016) Matthew J. Delano et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Biochemical Basis of Sestrin Physiological Activities

(2016) Allison Ho et al.   TRENDS IN BIOCHEMICAL SCIENCES

Endoplasmic Reticulum Stress in Immunity

(2015) Sarah E. Bettigole et al.   Annual Review of Immunology

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Defining dendritic cells

(2015) Barbara U Schraml et al.   CURRENT OPINION IN IMMUNOLOGY

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

ENDOPLASMIC RETICULUM STRESS IN SEPSIS

(2015) Mohammad Moshahid Khan et al.   SHOCK

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

ER stress induces NLRP3 inflammasome activation and hepatocyte death

(2015) C Lebeaupin et al.   Cell Death & Disease

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Enhanced Dendritic Cell Survival Attenuates Lipopolysaccharide-Induced Immunosuppression and Increases Resistance to Lethal Endotoxic Shock

(2014) E. L. Gautier et al.   JOURNAL OF IMMUNOLOGY

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

(2014) Xiaqiong Wang et al.   NATURE IMMUNOLOGY

Hepatoprotective role of Sestrin2 against chronic ER stress

(2014) Hwan-Woo Park et al.   Nature Communications

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

(2012) P Menu et al.   Cell Death & Disease

Profound and persistent decrease of circulating dendritic cells is associated with ICU-acquired infection in patients with septic shock

(2011) D. Grimaldi et al.   INTENSIVE CARE MEDICINE