Journal
AUTOIMMUNITY REVIEWS
Volume 18, Issue 4, Pages 359-368Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2019.02.006
Keywords
Immune checkpoints; Tolerogenic dendritic cells; Tolerance; Autoimmunity; Immunotherapy
Categories
Funding
- Corporacion de Fomento de la Produccion (CORFO) [13CTI-21526]
- Programa Semillero de Investigacion, DGI, Universidad de Antofagasta [5311]
- FONDECYT [1150862, 1190830]
- Millennium Institute on Immunology and Immunotherapy [P09-016-F]
- SEP-UNAM-FUNAM in Mexico
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The immune system is responsible for defending the host from a large variety of potential pathogens, while simultaneously avoiding immune reactivity towards self-components. Self-tolerance has to be tightly maintained throughout several central and peripheral processes; immune checkpoints are imperative for regulating the immunity/tolerance balance. Dendritic cells (DCs) are specialized cells that capture antigens, and either activate or inhibit antigen-specific T cells. Therefore, they play a key role at inducing and maintaining immune tolerance. DCs that suppress the immune response have been called tolerogenic dendritic cells (tolDCs). Given their potential as a therapy to prevent transplant rejection and autoimmune damage, several strategies are under development to generate tolDCs, in order to avoid activation and expansion of self-reactive T cells. In this article, we summarize the current knowledge relative to the main features of tolDCs, their mechanisms of action and their therapeutic use for autoimmune diseases. Based on the literature reviewed, autologous antigen-specific tolDCs might constitute a promising strategy to suppress autoreactive T cells and reduce detrimental inflammatory processes.
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