STING signaling activation inhibits HBV replication and attenuates the severity of liver injury and HBV-induced fibrosis

Toll-Like Receptor 5 Signaling Ameliorates Liver Fibrosis by Inducing Interferon β–Modulated IL-1 Receptor Antagonist in Mice

(2020) Zixiong Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

(2020) Daniel S. Leventhal et al.   Nature Communications

A novel recombinant cccDNA-based mouse model with long term maintenance of rcccDNA and antigenemia

(2020) Min Wu et al.   ANTIVIRAL RESEARCH

Epigenetic and epitranscriptomic regulation of viral replication

(2020) Kevin Tsai et al.   NATURE REVIEWS MICROBIOLOGY

SVIP alleviates CCl4-induced liver fibrosis via activating autophagy and protecting hepatocytes

(2019) Dan Jia et al.   Cell Death & Disease

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

(2019) Alberto Mantovani et al.   IMMUNITY

Nuclear Sensor IFI 16 Inhibits the Function of HBV ccc DNA by Integrating Innate Immune Activation and Epigenetic Suppression

(2019) Yuanyuan Yang et al.   HEPATOLOGY

IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis

(2019) Gang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-1 Family Cytokines: Keystones in Liver Inflammatory Diseases

(2019) Louise Barbier et al.   Frontiers in Immunology

Attenuated Pulmonary Fibrosis in Sialidase-3 Knockout (Neu3-/-) Mice

(2019) Tejas Rajeev Karhadkar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

STING modulators: Predictive significance in drug discovery

(2019) Xiangling Cui et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

YAP in Kupffer cells enhances the production of pro‐inflammatory cytokines and promotes the development of non‐alcoholic steatohepatitis

(2019) Kyoungsub Song et al.   HEPATOLOGY

The cGAS-STING pathway is a therapeutic target in a preclinical model of hepatocellular carcinoma

(2019) Martin K. Thomsen et al.   ONCOGENE

Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases

(2019) Ming-Ming Hu et al.   Annual Review of Immunology

Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism

(2018) Congrong Niu et al.   JOURNAL OF HEPATOLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

(2018) Maurizio Parola et al.   MOLECULAR ASPECTS OF MEDICINE

STING directly activates autophagy to tune the innate immune response

(2018) Dong Liu et al.   CELL DEATH AND DIFFERENTIATION

Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice

(2018) Xianjun Luo et al.   GASTROENTEROLOGY

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis

(2018) Yongsheng Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic hepatitis B virus infection

(2018) Wai-Kay Seto et al.   LANCET

Autophagy Induction Ameliorates Inflammatory Responses in Intestinal Ischemia–Reperfusion Through Inhibiting NLRP3 Inflammasome Activation

(2018) Zishuo Wang et al.   SHOCK

Recombinant covalently closed circular DNA of hepatitis B virus induces long-term viral persistence with chronic hepatitis in a mouse model

(2017) Gaiyun Li et al.   HEPATOLOGY

Epigenetic regulation of hepatitis B virus covalently closed circular DNA: Implications for epigenetic therapy against chronic hepatitis B

(2017) Xupeng Hong et al.   HEPATOLOGY

Targeting hepatic macrophages to treat liver diseases

(2017) Frank Tacke   JOURNAL OF HEPATOLOGY

HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production

(2017) Xin Yu et al.   JOURNAL OF HEPATOLOGY

Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice

(2016) Jihye Han et al.   Autophagy

Liver Fibrosis Reversion After Suppression of Hepatitis B Virus

(2016) Don C. Rockey   Clinics in Liver Disease

Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection

(2016) Martin K. Thomsen et al.   HEPATOLOGY

The role of innate immunity in the immunopathology and treatment of HBV infection

(2016) Mala K. Maini et al.   JOURNAL OF HEPATOLOGY

cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection

(2016) Chan-Wang J. Lio et al.   JOURNAL OF VIROLOGY

Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor

(2016) Adrien Decorsière et al.   NATURE

Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS

(2016) Line S. Reinert et al.   Nature Communications

Protocol for Isolation of Primary Human Hepatocytes and Corresponding Major Populations of Non-parenchymal Liver Cells

(2016) Victoria Kegel et al.   Jove-Journal of Visualized Experiments

Macrophage autophagy protects against liver fibrosis in mice

(2015) Jasper Lodder et al.   Autophagy

Targeting the Achilles heel of the hepatitis B virus: a review of current treatments against covalently closed circular DNA

(2015) Marawan Ahmed et al.   DRUG DISCOVERY TODAY

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B

(2015) Michael Nassal   GUT

HBx relieves chromatin-mediated transcriptional repression of hepatitis B viral cccDNA involving SETDB1 histone methyltransferase

(2015) Lise Rivière et al.   JOURNAL OF HEPATOLOGY

Hepatitis C Virus NS4B Can Suppress STING Accumulation To Evade Innate Immune Responses

(2015) Guanghui Yi et al.   JOURNAL OF VIROLOGY

Innate immunity against HIV-1 infection

(2015) Marcus Altfeld et al.   NATURE IMMUNOLOGY

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

STING Agonists Induce an Innate Antiviral Immune Response against Hepatitis B Virus

(2014) Fang Guo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression

(2014) Annika Klara Giegerich et al.   Autophagy

Over-activation of TLR5 signaling by high-dose flagellin induces liver injury in mice

(2014) Yang Xiao et al.   Cellular & Molecular Immunology

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways

(2014) Yinghui Liu et al.   JOURNAL OF VIROLOGY

Recombinant Covalently Closed Circular Hepatitis B Virus DNA Induces Prolonged Viral Persistence in Immunocompetent Mice

(2014) Zhihua Qi et al.   JOURNAL OF VIROLOGY

Hepatitis B virus infection

(2014) Christian Trépo et al.   LANCET

Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA

(2014) J. Lucifora et al.   SCIENCE

IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH Oxidase-mediated airway antiviral response

(2013) Karin Fink et al.   CELL RESEARCH

Toll-like receptor 7-mediated type I interferon signaling prevents cholestasis- and hepatotoxin-induced liver fibrosis

(2013) Yoon Seok Roh et al.   HEPATOLOGY

Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity

(2013) Qiang Ding et al.   JOURNAL OF HEPATOLOGY

Sterile Inflammation in the Liver

(2012) Paul Kubes et al.   GASTROENTEROLOGY

Transfer of HBV Genomes Using Low Doses of Adenovirus Vectors Leads to Persistent Infection in Immune Competent Mice

(2012) Li–Rung Huang et al.   GASTROENTEROLOGY

IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome

(2012) Laura Belloni et al.   JOURNAL OF CLINICAL INVESTIGATION

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Characterization of macroautophagic flux in vivo using a leupeptin-based assay

(2011) Jeffrey Haspel et al.   Autophagy

Association of intrahepatic cccDNA reduction with the improvement of liver histology in chronic hepatitis B patients receiving oral antiviral agents

(2011) Pin-Nan Cheng et al.   JOURNAL OF MEDICAL VIROLOGY

Adenovirus Type 5 Rupture of Lysosomes Leads to Cathepsin B-Dependent Mitochondrial Stress and Production of Reactive Oxygen Species

(2011) K. A. McGuire et al.   JOURNAL OF VIROLOGY

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

Total and covalently closed circular DNA detection in liver tissue of long-term survivors transplanted for HBV-related cirrhosis

(2010) Ilaria Lenci et al.   DIGESTIVE AND LIVER DISEASE

Type I Interferons Protect From Toll-Like Receptor 9–Associated Liver Injury and Regulate IL-1 Receptor Antagonist in Mice

(2010) Jan Petrasek et al.   GASTROENTEROLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

An Autophagy-Enhancing Drug Promotes Degradation of Mutant  1-Antitrypsin Z and Reduces Hepatic Fibrosis

(2010) T. Hidvegi et al.   SCIENCE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE