- Home
- Publications
- Publication Search
- Publication Details
Title
Iron and leukemia: new insights for future treatments
Authors
Keywords
Leukemia, Iron, Reactive oxygen species, Ferroptosis, Iron-based nanoparticles
Journal
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume 38, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-09-13
DOI
10.1186/s13046-019-1397-3
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cancer statistics, 2019
- (2019) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Eltrombopag treatment during induction chemotherapy for acute myeloid leukaemia: a randomised, double-blind, phase 2 study
- (2019) Noelle Frey et al. Lancet Haematology
- Improved survival outcomes and restoration of graft-vs-leukemia effect by deferasirox after allogeneic stem cell transplantation in acute myeloid leukemia
- (2019) Byung-Sik Cho et al. Cancer Medicine
- FDA-approved ferumoxytol displays anti-leukaemia efficacy against cells with low ferroportin levels
- (2019) Vicenta Trujillo-Alonso et al. Nature Nanotechnology
- Ferroptosis, a new form of cell death: opportunities and challenges in cancer
- (2019) Yanhua Mou et al. Journal of Hematology & Oncology
- Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction
- (2019) Francesca Vinchi et al. EUROPEAN HEART JOURNAL
- Low ferroportin expression in AML is correlated with good risk cytogenetics, improved outcomes and increased sensitivity to chemotherapy
- (2019) Maura Gasparetto et al. LEUKEMIA RESEARCH
- Emerging Strategies of Cancer Therapy Based on Ferroptosis
- (2018) Zheyu Shen et al. ADVANCED MATERIALS
- Alterations in Cellular Iron Metabolism Provide More Therapeutic Opportunities for Cancer
- (2018) Liangfu Zhou et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Iron-dependent cell death as executioner of cancer stem cells
- (2018) Bin Zhao et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Strategies for Enhancing the Permeation of CNS-Active Drugs through the Blood-Brain Barrier: A Review
- (2018) Isra’ Zeiadeh et al. MOLECULES
- A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death
- (2018) Armelle T. Mbaveng et al. PHYTOMEDICINE
- Prognostic value of Transferrin receptor-1 (CD71) Expression in Acute Lymphoblastic Leukemia
- (2018) Adel A Hagag et al. Endocrine Metabolic & Immune Disorders-Drug Targets
- Acute myeloid leukaemia
- (2018) Nicholas J Short et al. LANCET
- Revisiting Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Cancer: Saint or Sinner?
- (2018) Brigitte Bauvois et al. Cancers
- Ferritin heavy/light chain (FTH1/FTL) expression, serum ferritin levels, and their functional as well as prognostic roles in acute myeloid leukemia
- (2018) Sarah Bertoli et al. EUROPEAN JOURNAL OF HAEMATOLOGY
- DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin
- (2018) Jing Du et al. FREE RADICAL BIOLOGY AND MEDICINE
- Deferasirox selectively induces cell death in the clinically relevant population of leukemic CD34+CD38– cells through iron chelation, induction of ROS, and inhibition of HIF1α expression
- (2018) Saar Shapira et al. EXPERIMENTAL HEMATOLOGY
- Long-term survival of sorafenib-treated FLT3-ITD–positive acute myeloid leukaemia patients relapsing after allogeneic stem cell transplantation
- (2017) S.K. Metzelder et al. EUROPEAN JOURNAL OF CANCER
- Cytosolic iron chaperones: Proteins delivering iron cofactors in the cytosol of mammalian cells
- (2017) Caroline C. Philpott et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Deferasirox has strong anti-leukemia activity but may antagonize theanti-leukemia effect of doxorubicin
- (2017) Yu-Chien Chang et al. LEUKEMIA & LYMPHOMA
- Ascorbate regulates haematopoietic stem cell function and leukaemogenesis
- (2017) Michalis Agathocleous et al. NATURE
- Lipocalin-2 and iron trafficking in the tumor microenvironment
- (2017) Michaela Jung et al. PHARMACOLOGICAL RESEARCH
- Cytotoxicity of epunctanone and four other phytochemicals isolated from the medicinal plants Garcinia epunctata and Ptycholobium contortum towards multi-factorial drug resistant cancer
- (2017) Armelle T. Mbaveng et al. PHYTOMEDICINE
- Intravenous Versus Oral Iron Supplementation for the Treatment of Anemia in CKD: An Updated Systematic Review and Meta-analysis
- (2016) Daniel Shepshelovich et al. AMERICAN JOURNAL OF KIDNEY DISEASES
- Iron and cancer: recent insights
- (2016) David H. Manz et al. Annals of the New York Academy of Sciences
- Autophagy promotes ferroptosis by degradation of ferritin
- (2016) Wen Hou et al. Autophagy
- Improving antiproliferative effect of the anticancer drug cytarabine on human promyelocytic leukemia cells by coating on Fe 3 O 4 @SiO 2 nanoparticles
- (2016) Nahid Shahabadi et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- New insights into transfusion-related iron toxicity: Implications for the oncologist
- (2016) John B. Porter et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Expression of CD71 by flow cytometry in acute leukemias: More often seen in acute myeloid leukemia
- (2016) Pranav Dorwal et al. Indian Journal of Pathology and Microbiology
- Iron chelation: an adjuvant therapy to target metabolism, growth and survival of murine PTEN-deficient T lymphoma and human T lymphoblastic leukemia/lymphoma
- (2016) Joy Benadiba et al. LEUKEMIA & LYMPHOMA
- Adult Acute Lymphoblastic Leukemia
- (2016) Shilpa Paul et al. MAYO CLINIC PROCEEDINGS
- Antileukemia Effect of Ciclopirox Olamine Is Mediated by Downregulation of Intracellular Ferritin and Inhibition β-Catenin-c-Myc Signaling Pathway in Glucocorticoid Resistant T-ALL Cell Lines
- (2016) Jianrong Wu et al. PLoS One
- RSL3 and Erastin differentially regulate redox signaling to promote Smac mimetic-induced cell death
- (2016) Jasmin Dächert et al. Oncotarget
- Aberrant Wnt Signaling in Leukemia
- (2016) Frank Staal et al. Cancers
- Hepcidin: regulation of the master iron regulator
- (2015) Gautam Rishi et al. BIOSCIENCE REPORTS
- The iron chelator deferasirox affects redox signalling in haematopoietic stem/progenitor cells
- (2015) Tiziana Tataranni et al. BRITISH JOURNAL OF HAEMATOLOGY
- Hepcidin Regulation in Prostate and Its Disruption in Prostate Cancer
- (2015) Lia Tesfay et al. CANCER RESEARCH
- Ferritin: A Versatile Building Block for Bionanotechnology
- (2015) Günther Jutz et al. CHEMICAL REVIEWS
- Efficacy and safety of a novel combination of two oral chelators deferasirox/deferiprone over deferoxamine/deferiprone in severely iron overloaded young beta thalassemia major patients
- (2015) Mohsen S. Elalfy et al. EUROPEAN JOURNAL OF HAEMATOLOGY
- Hyperferritinemia at diagnosis predicts relapse and overall survival in younger AML patients with intermediate-risk cytogenetics
- (2015) Delphine Lebon et al. LEUKEMIA RESEARCH
- c-Myc plays part in drug resistance mediated by bone marrow stromal cells in acute myeloid leukemia
- (2015) Bing Xia et al. LEUKEMIA RESEARCH
- Glutaminolysis and Transferrin Regulate Ferroptosis
- (2015) Minghui Gao et al. MOLECULAR CELL
- Ferroptosis as a p53-mediated activity during tumour suppression
- (2015) Le Jiang et al. NATURE
- HSPB1 as a novel regulator of ferroptotic cancer cell death
- (2015) X Sun et al. ONCOGENE
- Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells
- (2015) Edna Ooko et al. PHYTOMEDICINE
- Safety and tolerability of eltrombopag versus placebo for treatment of thrombocytopenia in patients with advanced myelodysplastic syndromes or acute myeloid leukaemia: a multicentre, randomised, placebo-controlled, double-blind, phase 1/2 trial
- (2015) Uwe Platzbecker et al. Lancet Haematology
- Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer
- (2015) Saverio Candido et al. Oncotarget
- ROS-mediated iron overload injures the hematopoiesis of bone marrow by damaging hematopoietic stem/progenitor cells in mice
- (2015) Xiao Chai et al. Scientific Reports
- Mechanistic and regulatory aspects of intestinal iron absorption
- (2014) Sukru Gulec et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Reactive Oxygen Species Regulate Hematopoietic Stem Cell Self-Renewal, Migration and Development, As Well As Their Bone Marrow Microenvironment
- (2014) Aya Ludin et al. ANTIOXIDANTS & REDOX SIGNALING
- Iron Overload in Allogeneic Hematopoietic Cell Transplantation Outcome: A Meta-Analysis
- (2014) Philippe Armand et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- Modulation of monocytic leukemia cell function and survival by high gradient magnetic fields and mathematical modeling studies
- (2014) Vitalii Zablotskii et al. BIOMATERIALS
- c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells
- (2014) J. E. Roderick et al. BLOOD
- Deferasirox improves hematopoiesis after allogeneic hematopoietic SCT
- (2014) G Visani et al. BONE MARROW TRANSPLANTATION
- Targeted therapy with MXD3 siRNA, anti-CD22 antibody and nanoparticles for precursor B-cell acute lymphoblastic leukaemia
- (2014) Noriko Satake et al. BRITISH JOURNAL OF HAEMATOLOGY
- Regulation of Ferroptotic Cancer Cell Death by GPX4
- (2014) Wan Seok Yang et al. CELL
- Magnetic field enhanced convective diffusion of iron oxide nanoparticles in an osmotically disrupted cell culture model of the blood–brain barrier
- (2014) Zhizhi Sun et al. International Journal of Nanomedicine
- Cytotoxic effect of magnetic iron oxide nanoparticles synthesized via seaweed aqueous extract
- (2014) Farideh Namvar et al. International Journal of Nanomedicine
- Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity
- (2014) Yuki Kagoya et al. JOURNAL OF CLINICAL INVESTIGATION
- The role of iron in brain ageing and neurodegenerative disorders
- (2014) Roberta J Ward et al. LANCET NEUROLOGY
- The growth-inhibitory and apoptosis-inducing effect of deferoxamine combined with arsenic trioxide on HL-60 xenografts in nude mice
- (2014) Runhong Yu et al. LEUKEMIA RESEARCH
- Examination of HFE associations with childhood leukemia risk and extension to other iron regulatory genes
- (2014) Amy E. Kennedy et al. LEUKEMIA RESEARCH
- Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
- (2014) Scott J Dixon et al. eLife
- The IRP/IRE system in vivo: insights from mouse models
- (2014) Nicole Wilkinson et al. Frontiers in Pharmacology
- Neutrophil Gelatinase-Associated Lipocalin (NGAL), Pro-Matrix Metalloproteinase-9 (pro-MMP-9) and Their Complex Pro-MMP-9/NGAL in Leukaemias
- (2014) Sandrine Bouchet et al. Cancers
- Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies
- (2013) Mark D. Minden et al. AMERICAN JOURNAL OF HEMATOLOGY
- Nox Enzymes and New Thinking on Reactive Oxygen: A Double-Edged Sword Revisited
- (2013) J. David Lambeth et al. Annual Review of Pathology-Mechanisms of Disease
- The regulation of iron transport
- (2013) David M. Frazer et al. BIOFACTORS
- Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling
- (2013) P. S. Hole et al. BLOOD
- Iron and Cancer Risk--A Systematic Review and Meta-analysis of the Epidemiological Evidence
- (2013) A. Fonseca-Nunes et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Free iron catalyzes oxidative damage to hematopoietic cells/mesenchymal stem cellsin vitroand suppresses hematopoiesis in iron overload patients
- (2013) Wenyi Lu et al. EUROPEAN JOURNAL OF HAEMATOLOGY
- A phase II trial of sequential ribonucleotide reductase inhibition in aggressive myeloproliferative neoplasms
- (2013) J. F. Zeidner et al. HAEMATOLOGICA
- Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib
- (2013) Christophe Louandre et al. INTERNATIONAL JOURNAL OF CANCER
- Significance of CD71 expression by flow cytometry in diagnosis of acute leukemia
- (2013) Qian Liu et al. LEUKEMIA & LYMPHOMA
- The role of iron and reactive oxygen species in cell death
- (2013) Scott J Dixon et al. Nature Chemical Biology
- STEAP1 is overexpressed in cancers: A promising therapeutic target
- (2012) Jerome Moreaux et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Monocytic AML cells inactivate antileukemic lymphocytes: role of NADPH oxidase/gp91phox expression and the PARP-1/PAR pathway of apoptosis
- (2012) J. Aurelius et al. BLOOD
- Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation
- (2012) M. Roth et al. BLOOD
- Characterization of transferrin receptor-mediated endocytosis and cellular iron delivery of recombinant human serum transferrin from rice (Oryza sativa L.)
- (2012) Deshui Zhang et al. BMC BIOTECHNOLOGY
- Pre-transplantation iron chelation in patients with MDS or acute leukemia and iron overload undergoing myeloablative allo-SCT
- (2012) P Armand et al. BONE MARROW TRANSPLANTATION
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- Methyl and ethyl ketone analogs of salicylaldehyde isonicotinoyl hydrazone: Novel iron chelators with selective antiproliferative action
- (2012) Eliška Macková et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Cytometric evaluation of transferrin receptor 1 (CD71) in childhood acute lymphoblastic leukemia
- (2012) Anna Płoszyńska et al. FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
- Intestinal iron absorption
- (2012) Brie K. Fuqua et al. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
- Higherlipocalin 2expression may represent an independent favorable prognostic factor in cytogenetically normal acute myeloid leukemia
- (2012) Wen-Chi Yang et al. LEUKEMIA & LYMPHOMA
- Deferasirox exposure induces reactive oxygen species and reduces growth and viability of myelodysplastic hematopoietic progenitors
- (2012) Vinod Pullarkat et al. LEUKEMIA RESEARCH
- Rationally Designed Aberrant Kinase-Targeted Endogenous Protein Nanomedicine against Oncogene Mutated/Amplified Refractory Chronic Myeloid Leukemia
- (2012) Archana P. Retnakumari et al. MOLECULAR PHARMACEUTICS
- Uptake and release of metal ions by transferrin and interaction with receptor 1
- (2011) Jean-Michel El Hage Chahine et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Wnt Inhibitor Screen Reveals Iron Dependence of -Catenin Signaling in Cancers
- (2011) S. Song et al. CANCER RESEARCH
- Hepcidin expression in patients with acute leukaemia
- (2011) Pan-Pan Cheng et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Cellular Iron Depletion Stimulates the JNK and p38 MAPK Signaling Transduction Pathways, Dissociation of ASK1-Thioredoxin, and Activation of ASK1
- (2011) Yu Yu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Six-transmembrane epithelial antigen of the prostate and enhancer of zeste homolog 2 as immunotherapeutic targets for lung cancer
- (2011) Satoshi Hayashi et al. Journal of Translational Medicine
- Co-encapsulation of anti-BCR-ABL siRNA and imatinib mesylate in transferrin receptor-targeted sterically stabilized liposomes for chronic myeloid leukemia treatment
- (2010) Liliana S. Mendonça et al. BIOTECHNOLOGY AND BIOENGINEERING
- Comparison of Clinically Used and Experimental Iron Chelators for Protection against Oxidative Stress-Induced Cellular Injury
- (2010) Petra Bendova et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Deferasirox is a powerful NF- B inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging
- (2010) E. Messa et al. HAEMATOLOGICA
- Clinical Utility of Microarray-Based Gene Expression Profiling in the Diagnosis and Subclassification of Leukemia: Report From the International Microarray Innovations in Leukemia Study Group
- (2010) Torsten Haferlach et al. JOURNAL OF CLINICAL ONCOLOGY
- Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia
- (2010) Celine Callens et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Metabolism and the leukemic stem cell: Figure 1.
- (2010) Omar Abdel-Wahab et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Impact of Desferrioxamine Postallogeneic Hematopoietic Cell Transplantation in Relapse Incidence and Disease-Free Survival: A Retrospective Analysis
- (2010) Panayotis Kaloyannidis et al. TRANSPLANTATION
- The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1
- (2009) Junko H. Ohyashiki et al. CANCER SCIENCE
- Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation
- (2009) Edward Owusu-Ansah et al. NATURE
- Antitumor activity and mechanism of action of the iron chelator, Dp44mT, against leukemic cells
- (2008) Egarit Noulsri et al. AMERICAN JOURNAL OF HEMATOLOGY
- Synthesis and anti-cancer activity of covalent conjugates of artemisinin and a transferrin-receptor targeting peptide
- (2008) Steve Oh et al. CANCER LETTERS
- The effect of an iron (III) chelator, silybin, on the proliferation and cell cycle of Jurkat cells: A comparison with desferrioxamine
- (2008) Marjan Gharagozloo et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Phase I study of the ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehyde-thiosemicarbazone (3-AP) in combination with high dose cytarabine in patients with advanced myeloid leukemia
- (2008) Olatoyosi M. Odenike et al. INVESTIGATIONAL NEW DRUGS
- Neutrophil gelatinase-associated lipocalin expression in chronic myeloid leukemia
- (2008) Claire Villalva et al. LEUKEMIA & LYMPHOMA
- Transferrin Receptor-Targeted Lipid Nanoparticles for Delivery of an Antisense Oligodeoxyribonucleotide against Bcl-2
- (2008) Xiaojuan Yang et al. MOLECULAR PHARMACEUTICS
- Lipocalin 2 is required for BCR-ABL-induced tumorigenesis
- (2008) X Leng et al. ONCOGENE
- Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice
- (2008) Q. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Phase I study of the novel ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine®) in combination with the nucleoside analog fludarabine for patients with refractory acute leukemias and aggressive myeloproliferative disorders
- (2007) Judith E. Karp et al. LEUKEMIA RESEARCH
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started