Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol, and rapamycin

Molecular and Functional Networks Linked to Sarcopenia Prevention by Caloric Restriction in Rhesus Monkeys

(2020) Timothy W. Rhoads et al.   Cell Systems

The quest to slow ageing through drug discovery

(2020) Linda Partridge et al.   NATURE REVIEWS DRUG DISCOVERY

The effect of ABCB1 polymorphism on sirolimus in renal transplant recipients: a meta-analysis

(2020) Shuai Shao et al.   Translational Andrology and Urology

Mitochondrial pathways in human health and aging

(2020) Rebecca Bornstein et al.   MITOCHONDRION

SLC25A51 is a mammalian mitochondrial NAD+ transporter

(2020) Timothy S. Luongo et al.   NATURE

Comparative proteomics analysis of dietary restriction in Drosophila

(2020) Yue Gao et al.   PLoS One

Beyond calorie restriction: aging as a biological target for nutrient therapies

(2020) Steven N Austad et al.   CURRENT OPINION IN BIOTECHNOLOGY

Progress to Improve Oral Bioavailability and Beneficial Effects of Resveratrol

(2019) Adele Chimento et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

(2019) Frank Madeo et al.   Cell Metabolism

Mitochondrial targets of metformin—Are they physiologically relevant?

(2019) Alena Pecinová et al.   BIOFACTORS

Differential Effects of Rapamycin on Glucose Metabolism in Nine Inbred Strains

(2019) Peter C Reifsnyder et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

RNA Splicing by the Spliceosome

(2019) Max E. Wilkinson et al.   Annual Review of Biochemistry

Metformin Alters Upper Small Intestinal Microbiota that Impact a Glucose-SGLT1-Sensing Glucoregulatory Pathway

(2018) Paige V. Bauer et al.   Cell Metabolism

Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys

(2018) Timothy W. Rhoads et al.   Cell Metabolism

The Relationship Between Dietary Macronutrients and Hepatic Telomere Length in Aging Mice

(2017) Rahul Gokarn et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Epigenetic Regulatory Mechanisms Induced by Resveratrol

(2017) Guilherme Fernandes et al.   Nutrients

Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans

(2016) Benjamin P. Lee et al.   AGING CELL

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

(2016) Brian K. Kennedy et al.   Cell Metabolism

Nutritional ecology and the evolution of aging

(2016) David Raubenheimer et al.   EXPERIMENTAL GERONTOLOGY

Calories or protein? The effect of dietary restriction on lifespan in rodents is explained by calories alone

(2016) J.R. Speakman et al.   EXPERIMENTAL GERONTOLOGY

Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans

(2016) Caroline Heintz et al.   NATURE

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

(2016) Alessandro Bitto et al.   eLife

Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects

(2015) Pabalu P. Karunadharma et al.   AGING CELL

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

The impact of low-protein high-carbohydrate diets on aging and lifespan

(2015) David G. Le Couteur et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Therapeutic Concentrations of Metformin: A Systematic Review

(2015) Farshad Kajbaf et al.   CLINICAL PHARMACOKINETICS

Deletion of the Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity

(2015) Hiroya Ohta et al.   Scientific Reports

A Conserved Transcriptional Signature of Delayed Aging and Reduced Disease Vulnerability Is Partially Mediated by SIRT3

(2015) Jamie L. Barger et al.   PLoS One

MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression across Cancer Cell Line Proteomes

(2014) Graeme C. McAlister et al.   ANALYTICAL CHEMISTRY

The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

(2014) Samantha M. Solon-Biet et al.   Cell Metabolism

Perspective: Tricks of the trade

(2014) Stephen J. Simpson et al.   NATURE

Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome

(2014) Wilson C. Fok et al.   PLoS One

Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver

(2013) Wilson C. Fok et al.   AGING CELL

Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite

(2013) Mardi S. Byerly et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Starvation actively inhibits splicing of glucose-6-phosphate dehydrogenase mRNA via a bifunctional ESE/ESS element bound by hnRNP K

(2013) T.J. Cyphert et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Serine Arginine Splicing Factor 3 Is Involved in Enhanced Splicing of Glucose-6-phosphate Dehydrogenase RNA in Response to Nutrients and Hormones in Liver

(2012) Callee M. Walsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic analysis of liver mitochondria of apolipoprotein E knockout mice treated with metformin

(2012) Aneta Stachowicz et al.   Journal of Proteomics

Dietary Protein Affects Gene Expression and Prevents Lipid Accumulation in the Liver in Mice

(2012) Jessica Schwarz et al.   PLoS One

Resveratrol Inhibits Protein Translation in Hepatic Cells

(2011) Eugenia Villa-Cuesta et al.   PLoS One

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse

(2009) William R Swindell   BMC GENOMICS

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

Lifespan and reproduction in Drosophila: New insights from nutritional geometry

(2008) K. P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA