Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila

Renal Purge of Hemolymphatic Lipids Prevents the Accumulation of ROS-Induced Inflammatory Oxidized Lipids and Protects Drosophila from Tissue Damage

(2020) Xiaoxue Li et al.   IMMUNITY

Mitochondrial Functions in Infection and Immunity

(2020) Varnesh Tiku et al.   TRENDS IN CELL BIOLOGY

Systemic Immunometabolism: Challenges and Opportunities

(2020) Alexander Lercher et al.   IMMUNITY

The Drosophila midgut and the systemic coordination of lipid-dependent energy homeostasis

(2020) Xiao Zhao et al.   Current Opinion in Insect Science

An evolutionary perspective on immunometabolism

(2019) Andrew Wang et al.   SCIENCE

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

(2019) Abhishek A. Chakraborty et al.   SCIENCE

Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance

(2019) Kirthana Ganeshan et al.   CELL

Relaxed Selection Limits Lifespan by Increasing Mutation Load

(2019) Rongfeng Cui et al.   CELL

Sugar Alcohols of Polyol Pathway Serve as Alarmins to Mediate Local-Systemic Innate Immune Communication in Drosophila

(2019) Shuo Yang et al.   Cell Host & Microbe

Adult Drosophila Lack Hematopoiesis but Rely on a Blood Cell Reservoir at the Respiratory Epithelia to Relay Infection Signals to Surrounding Tissues

(2019) Pablo Sanchez Bosch et al.   DEVELOPMENTAL CELL

Inflammation-Modulated Metabolic Reprogramming Is Required for DUOX-Dependent Gut Immunity in Drosophila

(2018) Kyung-Ah Lee et al.   Cell Host & Microbe

Immune–metabolic interactions during systemic and enteric infection in Drosophila

(2018) Kyung-Ah Lee et al.   Current Opinion in Insect Science

Metabolic regulation of inflammation

(2017) Timo Gaber et al.   Nature Reviews Rheumatology

Drosophila muscles regulate the immune response against wasp infection via carbohydrate metabolism

(2017) Hairu Yang et al.   Scientific Reports

Stochastic variation in the initial phase of bacterial infection predicts the probability of survival in D. melanogaster

(2017) David Duneau et al.   eLife

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens

(2016) Yohann Nédélec et al.   CELL

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

(2016) Marco Sciacovelli et al.   NATURE

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate

(2016) Petros A. Tyrakis et al.   NATURE

TrpA1 Regulates Defecation of Food-Borne Pathogens under the Control of the Duox Pathway

(2016) Eun Jo Du et al.   PLoS Genetics

NF-κB pathway controls mitochondrial dynamics

(2015) M Laforge et al.   CELL DEATH AND DIFFERENTIATION

Muscle as a “Mediator” of Systemic Metabolism

(2015) Kedryn K. Baskin et al.   Cell Metabolism

The Transgenic RNAi Project at Harvard Medical School: Resources and Validation

(2015) L. A. Perkins et al.   GENETICS

GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution

(2015) Melis Karaca et al.   Cell Reports

The Acetate Switch of an Intestinal Pathogen Disrupts Host Insulin Signaling and Lipid Metabolism

(2014) Saiyu Hang et al.   Cell Host & Microbe

Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants

(2014) P. Klein et al.   EMBO JOURNAL

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

(2014) Bryce W. Carey et al.   NATURE

Quantifying Drosophila food intake: comparative analysis of current methodology

(2014) Sonali A Deshpande et al.   NATURE METHODS

Heterogeneity in immune responses: from populations to single cells

(2014) Rahul Satija et al.   TRENDS IN IMMUNOLOGY

MEF2 Is an In Vivo Immune-Metabolic Switch

(2013) Rebecca I. Clark et al.   CELL

Tolerance of Infections

(2012) Janelle S. Ayres et al.   Annual Review of Immunology

Sodium Dependent Multivitamin Transporter (SMVT): A Potential Target for Drug Delivery

(2012) Aswani Dutt Vadlapudi et al.   CURRENT DRUG TARGETS

Lipid droplet-based storage fat metabolism inDrosophila: Fig. 1.

(2012) Ronald P. Kühnlein   JOURNAL OF LIPID RESEARCH

Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila

(2012) M. Rera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipoproteins in Drosophila melanogaster—Assembly, Function, and Influence on Tissue Lipid Composition

(2012) Wilhelm Palm et al.   PLoS Genetics

Targeting the motor regulator Klar to lipid droplets

(2011) Yanxun V Yu et al.   BMC CELL BIOLOGY

Enteric Neurons and Systemic Signals Couple Nutritional and Reproductive Status with Intestinal Homeostasis

(2011) Paola Cognigni et al.   Cell Metabolism

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

(2011) Claudio Mauro et al.   NATURE CELL BIOLOGY

Thermal sensitivity of mitochondrial metabolism in two distinct mitotypes of Drosophila simulans: evaluation of mitochondrial plasticity

(2010) N. Pichaud et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Lipoprotein Particles Cross the Blood-Brain Barrier in Drosophila

(2010) M. Brankatschk et al.   JOURNAL OF NEUROSCIENCE

Glutamate joins the ranks of immunomodulators

(2010) Anna M Hansen et al.   NATURE MEDICINE

CF2 Represses Actin 88F Gene Expression and Maintains Filament Balance during Indirect Flight Muscle Development in Drosophila

(2010) Kathleen M. Gajewski et al.   PLoS One

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

The Role of Anorexia in Resistance and Tolerance to Infections in Drosophila

(2009) Janelle S. Ayres et al.   PLOS BIOLOGY

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

(2008) Gerasimos P. Sykiotis et al.   DEVELOPMENTAL CELL