Journal
NATURE MEDICINE
Volume 16, Issue 8, Pages 856-858Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm0810-856
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Funding
- Intramural NIH HHS [ZIA EY000184-28] Funding Source: Medline
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Elevated amounts of glutamate, which acts as a neurotransmitter but is also a neurotoxin, are a hallmark of the autoimmune neurological disease multiple sclerosis and may contribute to its pathology. The discovery that a receptor for glutamate can inhibit the development of autoimmunity and protect from neuroinflammation in a mouse model of multiple sclerosis suggests that glutamate may also have a protective role and that its receptor may represent a therapeutic target (pages 897-902).
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