NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis

Noncoding RNA therapeutics — challenges and potential solutions

(2021) Melanie Winkle et al.   NATURE REVIEWS DRUG DISCOVERY

Long non-coding RNA Neat1 regulates adaptive behavioural response to stress in mice

(2020) Michail S. Kukharsky et al.   Translational Psychiatry

Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52

(2020) Wen-liang Wang et al.   ACTA PHARMACOLOGICA SINICA

PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression

(2019) Mi Kyung Park et al.   Nature Communications

The lncRNA Neat1 promotes activation of inflammasomes in macrophages

(2019) Pengfei Zhang et al.   Nature Communications

The lncRNA NEAT1_1 is seemingly dispensable for normal tissue homeostasis and cancer cell growth.

(2019) Carmen Adriaens et al.   RNA

Forced isoform switching of Neat1_1 to Neat1_2 leads to the loss of Neat1_1 and the hyperformation of paraspeckles but does not affect the development and growth of mice

(2019) Momo Isobe et al.   RNA

miR-218 and miR-129 regulate breast cancer progression by targeting Lamins

(2018) Stephanie Rebecca Setijono et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Long noncoding RNA complementarity and target transcripts abundance

(2018) Richard W. Zealy et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation

(2018) Tomohiro Yamazaki et al.   MOLECULAR CELL

Structural analyses of NEAT1 lncRNAs suggest long-range RNA interactions that may contribute to paraspeckle architecture

(2018) Yizhu Lin et al.   NUCLEIC ACIDS RESEARCH

Molecular link between glucose and glutamine consumption in cancer cells mediated by CtBP and SIRT4

(2018) Li Wang et al.   Oncogenesis

Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer

(2018) Subhamoy Dasgupta et al.   NATURE

Integrated proteotranscriptomics of breast cancer reveals globally increased protein-mRNA concordance associated with subtypes and survival

(2018) Wei Tang et al.   Genome Medicine

Neat1 is a p53-inducible lincRNA essential for transformation suppression

(2017) Stephano S. Mello et al.   GENES & DEVELOPMENT

The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer

(2017) Wanjin Li et al.   JOURNAL OF CLINICAL INVESTIGATION

AUF1 facilitates microRNA-mediated gene silencing

(2017) Kyung-Won Min et al.   NUCLEIC ACIDS RESEARCH

Functional dissection of NEAT1 using genome editing reveals substantial localization of the NEAT1_1 isoform outside paraspeckles

(2017) Ruohan Li et al.   RNA

p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity

(2016) Carmen Adriaens et al.   NATURE MEDICINE

BindUP: a web server for non-homology-based prediction of DNA and RNA binding proteins

(2016) Inbal Paz et al.   NUCLEIC ACIDS RESEARCH

Linking Long Noncoding RNA Localization and Function

(2016) Ling-Ling Chen   TRENDS IN BIOCHEMICAL SCIENCES

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

Comparative Proteome Analysis Revealing an 11-Protein Signature for Aggressive Triple-Negative Breast Cancer

(2014) Ning Qing Liu et al.   JNCI-Journal of the National Cancer Institute

The Long Noncoding RNAs NEAT1 and MALAT1 Bind Active Chromatin Sites

(2014) Jason A. West et al.   MOLECULAR CELL

Enzyme clustering accelerates processing of intermediates through metabolic channeling

(2014) Michele Castellana et al.   NATURE BIOTECHNOLOGY

The long noncoding RNA Neat1 is required for mammary gland development and lactation

(2014) Laura Standaert et al.   RNA

PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity

(2014) Je-Hyun Yoon et al.   Nature Communications

The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer

(2014) Dimple Chakravarty et al.   Nature Communications

Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes

(2014) Sebastiaan van Heesch et al.   GENOME BIOLOGY

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling

(2013) Su Jung Song et al.   CELL

Post-translational modifications and the Warburg effect

(2013) T Hitosugi et al.   ONCOGENE

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

(2012) Taro Hitosugi et al.   CANCER CELL

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

Alternative 3′-end processing of long noncoding RNA initiates construction of nuclear paraspeckles

(2012) Takao Naganuma et al.   EMBO JOURNAL

A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails

(2012) J. E. Wilusz et al.   GENES & DEVELOPMENT

Passenger deletions generate therapeutic vulnerabilities in cancer

(2012) Florian L. Muller et al.   NATURE

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex

(2012) Andrea Giovanni Murachelli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

α-Enolase binds to RNA

(2011) Liliana Hernández-Pérez et al.   BIOCHIMIE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Analysis and Prediction of RNA-Binding Residues Using Sequence, Evolutionary Conservation, and Predicted Secondary Structure and Solvent Accessibility

(2011) Tuo Zhang et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice

(2011) Shinichi Nakagawa et al.   JOURNAL OF CELL BIOLOGY

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

Nucleotide-binding domain of phosphoglycerate kinase 1 reduces tumor growth by suppressing COX-2 expression

(2010) Ming-Yi Ho et al.   CANCER SCIENCE

The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

(2010) K. E. Wellen et al.   GENES & DEVELOPMENT

An Architectural Role for a Nuclear Noncoding RNA: NEAT1 RNA Is Essential for the Structure of Paraspeckles

(2009) Christine M. Clemson et al.   MOLECULAR CELL

MENε/β noncoding RNAs are essential for structural integrity of nuclear paraspeckles

(2009) Yasnory T. F. Sasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

MEN  /  nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles

(2008) H. Sunwoo et al.   GENOME RESEARCH

The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network

(2008) Min Sup Song et al.   NATURE