De novo deletions and duplications at recombination hotspots in mouse germlines

DNA-driven condensation assembles the meiotic DNA break machinery

(2021) Corentin Claeys Bouuaert et al.   NATURE

Long-read sequencing of 3,622 Icelanders provides insight into the role of structural variants in human diseases and other traits

(2021) Doruk Beyter et al.   NATURE GENETICS

Spo11 generates gaps through concerted cuts at sites of topological stress

(2021) Silvia Prieler et al.   NATURE

Concerted cutting by Spo11 illuminates meiotic DNA break mechanics

(2021) Dominic Johnson et al.   NATURE

ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis

(2020) Jacob Paiano et al.   Nature Communications

Molecular structures and mechanisms of DNA break processing in mouse meiosis

(2020) Shintaro Yamada et al.   GENES & DEVELOPMENT

Mechanistic Insight into Crossing over during Mouse Meiosis

(2020) Shaun E. Peterson et al.   MOLECULAR CELL

A structural variation reference for medical and population genetics

(2020) Ryan L. Collins et al.   NATURE

A pathway for error-free non-homologous end joining of resected meiotic double-strand breaks

(2020) Talia Hatkevich et al.   NUCLEIC ACIDS RESEARCH

Transition from a meiotic to a somatic-like DNA damage response during the pachytene stage in mouse meiosis

(2019) Andrea Enguita-Marruedo et al.   PLoS Genetics

CRISPResso2 provides accurate and rapid genome editing sequence analysis

(2019) Kendell Clement et al.   NATURE BIOTECHNOLOGY

A high-resolution map of non-crossover events reveals impacts of genetic diversity on mammalian meiotic recombination

(2019) Ran Li et al.   Nature Communications

Control of meiotic double-strand-break formation by ATM: local and global views

(2018) Agnieszka Lukaszewicz et al.   CELL CYCLE

Mechanistic View and Genetic Control of DNA Recombination during Meiosis

(2018) Marie-Claude Marsolier-Kergoat et al.   MOLECULAR CELL

Interdependent and separable functions ofCaenorhabditis elegansMRN-C complex members couple formation and repair of meiotic DSBs

(2018) Chloe Girard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physical basis for long-distance communication along meiotic chromosomes

(2018) Kyle R. Fowler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory control of DNA end resection by Sae2 phosphorylation

(2018) Elda Cannavo et al.   Nature Communications

Hotspots for Initiation of Meiotic Recombination

(2018) Andrew J. Tock et al.   Frontiers in Genetics

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair

(2017) Chun-Chin Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A global view of meiotic double-strand break end resection

(2017) Eleni P. Mimitou et al.   SCIENCE

The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair

(2016) Julian Lange et al.   CELL

Meiotic DSB patterning: A multifaceted process

(2016) Tim J. Cooper et al.   CELL CYCLE

The evolutionary turnover of recombination hot spots contributes to speciation in mice

(2016) Fatima Smagulova et al.   GENES & DEVELOPMENT

Numerical and spatial patterning of yeast meiotic DNA breaks by Tel1

(2016) Neeman Mohibullah et al.   GENOME RESEARCH

Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice

(2016) Benjamin Davies et al.   NATURE

Analyzing CRISPR genome-editing experiments with CRISPResso

(2016) Luca Pinello et al.   NATURE BIOTECHNOLOGY

Mechanisms of germ line genome instability

(2016) Seoyoung Kim et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Gradual Implementation of the Meiotic Recombination Program via Checkpoint Pathways Controlled by Global DSB Levels

(2015) Neeraj Joshi et al.   MOLECULAR CELL

Tel1ATM-mediated interference suppresses clustered meiotic double-strand-break formation

(2015) Valerie Garcia et al.   NATURE

Insight into biases and sequencing errors for amplicon sequencing with the Illumina MiSeq platform

(2015) Melanie Schirmer et al.   NUCLEIC ACIDS RESEARCH

Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

(2015) Agnel Sfeir et al.   TRENDS IN BIOCHEMICAL SCIENCES

Meiotic Recombination: The Essence of Heredity

(2015) Neil Hunter   Cold Spring Harbor Perspectives in Biology

PRDM9 Drives Evolutionary Erosion of Hotspots in Mus musculus through Haplotype-Specific Initiation of Meiotic Recombination

(2015) Christopher L. Baker et al.   PLoS Genetics

Reduced Crossover Interference and Increased ZMM-Independent Recombination in the Absence of Tel1/ATM

(2015) Carol M. Anderson et al.   PLoS Genetics

Self-Organization of Meiotic Recombination Initiation: General Principles and Molecular Pathways

(2014) Scott Keeney et al.   Annual Review of Genetics

Sequencing the Mouse Y Chromosome Reveals Convergent Gene Acquisition and Amplification on Both Sex Chromosomes

(2014) Y.Q. Shirleen Soh et al.   CELL

Optimized flow cytometry isolation of murine spermatocytes

(2014) Valeriya Gaysinskaya et al.   CYTOMETRY PART A

Pseudosynapsis and Decreased Stringency of Meiotic Repair Pathway Choice on the Hemizygous Sex Chromosome of Caenorhabditis elegans Males

(2014) Paula M. Checchi et al.   GENETICS

Homologue engagement controls meiotic DNA break number and distribution

(2014) Drew Thacker et al.   NATURE

Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics

(2014) Francesca Cole et al.   NATURE GENETICS

ATM specifically mediates repair of double-strand breaks with blocked DNA ends

(2014) Alejandro Álvarez-Quilón et al.   Nature Communications

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

(2013) Luis Ignacio Toledo et al.   CELL

Impaired Resection of Meiotic Double-Strand Breaks Channels Repair to Nonhomologous End Joining in Caenorhabditis elegans

(2013) Y. Yin et al.   MOLECULAR AND CELLULAR BIOLOGY

RPA Coordinates DNA End Resection and Prevents Formation of DNA Hairpins

(2013) Huan Chen et al.   MOLECULAR CELL

COM-1 Promotes Homologous Recombination during Caenorhabditis elegans Meiosis by Antagonizing Ku-Mediated Non-Homologous End Joining

(2013) Bennie B. L. G. Lemmens et al.   PLoS Genetics

Genetic recombination is directed away from functional genomic elements in mice

(2012) Kevin Brick et al.   NATURE

Homeostatic control of recombination is implemented progressively in mouse meiosis

(2012) Francesca Cole et al.   NATURE CELL BIOLOGY

A Hierarchical Combination of Factors Shapes the Genome-wide Topography of Yeast Meiotic Recombination Initiation

(2011) Jing Pan et al.   CELL

ATM controls meiotic double-strand-break formation

(2011) Julian Lange et al.   NATURE

Meiotic double-strand breaks occur once per pair of (sister) chromatids and, via Mec1/ATR and Tel1/ATM, once per quartet of chromatids

(2011) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive, Fine-Scale Dissection of Homologous Recombination Outcomes at a Hot Spot in Mouse Meiosis

(2010) Francesca Cole et al.   MOLECULAR CELL

Genetic probing of homologous recombination and non-homologous end joining during meiotic prophase in irradiated mouse spermatocytes

(2010) Emad A. Ahmed et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS