Spo11 generates gaps through concerted cuts at sites of topological stress

Structural and functional characterization of the Spo11 core complex

(2021) Corentin Claeys Bouuaert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA-driven condensation assembles the meiotic DNA break machinery

(2021) Corentin Claeys Bouuaert et al.   NATURE

Concerted cutting by Spo11 illuminates meiotic DNA break mechanics

(2021) Dominic Johnson et al.   NATURE

Negative supercoil at gene boundaries modulates gene topology

(2020) Yathish Jagadheesh Achar et al.   NATURE

Mapping DNA Topoisomerase Binding and Cleavage Genome Wide Using Next-Generation Sequencing Techniques

(2020) Shannon J. McKie et al.   Genes

Topoisomerases Modulate the Timing of Meiotic DNA Breakage and Chromosome Morphogenesis in Saccharomyces cerevisiae

(2020) Jonna Heldrich et al.   GENETICS

A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome

(2019) William H. Gittens et al.   Nature Communications

Pervasive, Coordinated Protein-Level Changes Driven by Transcript Isoform Switching during Meiosis

(2018) Ze Cheng et al.   CELL

Mechanistic View and Genetic Control of DNA Recombination during Meiosis

(2018) Marie-Claude Marsolier-Kergoat et al.   MOLECULAR CELL

Topoisomerase VI senses and exploits both DNA crossings and bends to facilitate strand passage

(2018) Timothy J Wendorff et al.   eLife

Contrasting evolutionary genome dynamics between domesticated and wild yeasts

(2017) Jia-Xing Yue et al.   NATURE GENETICS

The consequences of sequence erosion in the evolution of recombination hotspots

(2017) Irene Tiemann-Boege et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A global view of meiotic double-strand break end resection

(2017) Eleni P. Mimitou et al.   SCIENCE

Concerted action of the MutLβ heterodimer and Mer3 helicase regulates the global extent of meiotic gene conversion

(2017) Yann Duroc et al.   eLife

Numerical and spatial patterning of yeast meiotic DNA breaks by Tel1

(2016) Neeman Mohibullah et al.   GENOME RESEARCH

A DNA topoisomerase VI-like complex initiates meiotic recombination

(2016) N. Vrielynck et al.   SCIENCE

The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation

(2016) T. Robert et al.   SCIENCE

High-Resolution Global Analysis of the Influences of Bas1 and Ino4 Transcription Factors on Meiotic DNA Break Distributions inSaccharomyces cerevisiae

(2015) Xuan Zhu et al.   GENETICS

Tel1ATM-mediated interference suppresses clustered meiotic double-strand-break formation

(2015) Valerie Garcia et al.   NATURE

Nonparadoxical evolutionary stability of the recombination initiation landscape in yeast

(2015) I. Lam et al.   SCIENCE

High-Resolution Global Analysis of the Influences of Bas1 and Ino4 Transcription Factors on Meiotic DNA Break Distributions inSaccharomyces cerevisiae

(2015) Xuan Zhu et al.   GENETICS

Evolutionarily diverse determinants of meiotic DNA break and recombination landscapes across the genome

(2014) Kyle R. Fowler et al.   GENOME RESEARCH

Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)

(2014) Rui Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NextGenMap: fast and accurate read mapping in highly polymorphic genomes

(2013) Fritz J. Sedlazeck et al.   BIOINFORMATICS

Budding Yeast ATM/ATR Control Meiotic Double-Strand Break (DSB) Levels by Down-Regulating Rec114, an Essential Component of the DSB-machinery

(2013) Jesús A. Carballo et al.   PLoS Genetics

Smc5/6-Mms21 Prevents and Eliminates Inappropriate Recombination Intermediates in Meiosis

(2013) Martin Xaver et al.   PLoS Genetics

Spp1, a Member of the Set1 Complex, Promotes Meiotic DSB Formation in Promoters by Tethering Histone H3K4 Methylation Sites to Chromosome Axes

(2012) Vérane Sommermeyer et al.   MOLECULAR CELL

Summarizing and correcting the GC content bias in high-throughput sequencing

(2012) Yuval Benjamini et al.   NUCLEIC ACIDS RESEARCH

Spo11-Accessory Proteins Link Double-Strand Break Sites to the Chromosome Axis in Early Meiotic Recombination

(2011) Silvia Panizza et al.   CELL

A Hierarchical Combination of Factors Shapes the Genome-wide Topography of Yeast Meiotic Recombination Initiation

(2011) Jing Pan et al.   CELL

Meiotic double-strand breaks occur once per pair of (sister) chromatids and, via Mec1/ATR and Tel1/ATM, once per quartet of chromatids

(2011) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Resolution View of the Yeast Meiotic Program Revealed by Ribosome Profiling

(2011) G. A. Brar et al.   SCIENCE

Genome-Wide Analysis of Heteroduplex DNA in Mismatch Repair–Deficient Yeast Cells Reveals Novel Properties of Meiotic Recombination Pathways

(2011) Emmanuelle Martini et al.   PLoS Genetics

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Magnetic torque tweezers: measuring torsional stiffness in DNA and RecA-DNA filaments

(2010) Jan Lipfert et al.   NATURE METHODS

Locally, Meiotic Double-Strand Breaks Targeted by Gal4BD-Spo11 Occur at Discrete Sites with a Sequence Preference

(2009) H. Murakami et al.   MOLECULAR AND CELLULAR BIOLOGY

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

(2009) Felipe Cortes Ledesma et al.   NATURE

Measurement of the Torque on a Single Stretched and Twisted DNA Using Magnetic Tweezers

(2009) Francesco Mosconi et al.   PHYSICAL REVIEW LETTERS

Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites

(2008) Valérie Borde et al.   EMBO JOURNAL

The Anchor-Away Technique: Rapid, Conditional Establishment of Yeast Mutant Phenotypes

(2008) Hirohito Haruki et al.   MOLECULAR CELL

High-resolution mapping of meiotic crossovers and non-crossovers in yeast

(2008) Eugenio Mancera et al.   NATURE