Article
Engineering, Environmental
Yu Chen, Manav Bhati, Benjamin W. Walls, Bo Wang, Michael S. Wong, Thomas P. Senftle
Summary: This study investigates the photocatalytic oxidation of perfluorocarboxylic acids (PFCA) on hexagonal boron nitride (hBN) and finds that longer-chain PFCAs are more effectively degraded due to stronger adsorption. The researchers also discover that a nitrogen-boron substitutional defect can enhance UVC absorption and PFCA oxidation on hBN.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Robert J. Mayer, Harpreet Kaur, Sophia A. Rauscher, Joseph Moran
Summary: Metal ions can catalyze transamination under biologically relevant conditions, with Cu2+, Ni2+, Co2+, and V5+ identified as the most active. These ions primarily accelerate the reaction by stabilizing key imine intermediates or increasing the acidity of the bound imine. Direct metal ion-catalyzed amino group transfer is highly favored even in the absence of cofactors or protein catalysts under biologically compatible reaction conditions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Physical
Xiaowa Nie, Wenjia Wan, Zeshi Zhang, Yonggang Chen, Michael J. Janik, Chunshan Song, Xinwen Guo
Summary: The study revealed that the conversion of hydroquinone over oxygen-defective anatase supported gold catalyst involves key reaction intermediates such as benzoquinone, 1,4-cyclohexanediol, and cyclohexanol, with the dominant pathway being 1,4-cyclohexanediol leading to cyclohexane as the main product. The presence of oxygen vacancies on the catalyst surface and the interaction between gold and titania play crucial roles in facilitating the reaction and stabilizing intermediates.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Chemistry, Multidisciplinary
Maosheng Li, Hongyu Li, Xiaoyong Zhang, Xianhong Wang, Youhua Tao
Summary: Exploiting non-covalent interactions to catalyze ionic polymerizations is still in its early stages. A recent study demonstrated non-covalent anion-binding catalysis for living cationic polymerization of vinyl ethers. This study further investigates the structure-reactivity relationships and roles of anion-binding interactions in the catalytic process. The findings provide insights into the mechanism of anion-binding catalytic polymerization and offer guidance for future catalyst design.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
Damian Lobato-Marquez, Jingwei Xu, Gizem Oezbaykal Gueler, Adaobi Ojiakor, Martin Pilhofer, Serge Mostowy
Summary: Septins are cytoskeletal proteins that form cage-like structures to restrict the movement of bacteria within cells. Research shows that septin complexes can recognize bacterial cells and assemble as filaments on their surface.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Mingyang Sun, Zhongcong Xie, Jiaqiang Zhang, Yufang Leng
Summary: With the advancement of technology, more infants are receiving general anesthesia shortly after birth, which may impact the function and structure of the developing infant brain. The exposure to sevoflurane during development can lead to long-lasting negative effects on the brain, with mechanisms including neural cell death, neural cell damage, impaired assembly and plasticity of neural circuits, tau phosphorylation, and neuroendocrine effects being important factors to consider. Advanced technologies and methods are needed to determine the underlying mechanisms and guide prevention and treatment of sevoflurane-induced neurotoxicity.
CELL BIOLOGY AND TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jiawei Han, Chuchu Zhang, Yanpei Zhang, Xiaoqian Liu, Jue Wang
Summary: Different from previous co-amorphous systems, the co-amorphous resveratrol and piperine (RES-PIP CM) form a gel during dissolution, resulting in significantly lower dissolution compared to the original crystalline drugs. This study investigates the gel formation mechanism and seeks to eliminate gelation. The dissolution performance and gel properties of RES-PIP CM are affected by medium temperature and stoichiometric ratio. Mesoporous silica and attapulgite materials provide a barrier and hinder self-assembly and aggregation, achieving degelation and improved dissolution. This study highlights the importance of recognizing gelation potential and provides a strategy to eliminate gelation in co-amorphous drug products.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Endocrinology & Metabolism
Mengyu Zhang, Wen Jiang, Ganghua Lu, Ru Wang, Zhongwei Lv, Dan Li
Summary: Hyperthyroidism is a condition characterized by excessive production of thyroid hormones, with Graves' disease being the most common cause. Disease models have been established, and novel treatments for Graves' disease and Graves' orbitopathy have been discovered. Potential therapeutic targets have also been identified in mouse models of Graves' orbitopathy. Human placental mesenchymal stem cells, fucoxanthin, and icariin may provide alternative therapies in addition to existing drugs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Fuhua Xu, Jiaying Yan, Yanlan Wang, Xiang Liu
Summary: This study reports the design and synthesis of carbon nanosphere-stabilized Pd nanoparticles (Pd/CNS) for the direct generation of H-2 upon SF hydrolysis in the presence of Fe3+. The kinetic study and detailed mechanistic investigations confirm that the concerted process between the cleavage of O-H bond in H2O and -O2C-H bond oxidative addition is the rate-controlling step in SF hydrolysis. This work provides a new chemical hydrogen storage material (HCOONa) for the high-efficiency generation, transport, and storage of H-2.
Article
Pharmacology & Pharmacy
Jiawei Han, Luyuan Li, Zunting Pang, Meiling Su, Xiaoshuang He, Shuai Qian, Jianjun Zhang, Yuan Gao, Yuanfeng Wei
Summary: The gelation mechanism of amorphous curcumin (CUR) was explored in this study, and it was found that temperature and pH affected its dissolution and gel properties. The addition of hydrophilic excipients accelerated gel formation, while hydrophobic excipients weakened or eliminated gelation.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Cell Biology
Hongfu Jin, Shigang Jiang, Ruomei Wang, Yi Zhang, Jiangtao Dong, Yusheng Li
Summary: Integrins, a family of transmembrane proteins, play essential roles in osteoarthritis (OA). Dysfunction of integrins has been shown to be involved in the pathogenesis of OA. Understanding the roles of integrins in OA may influence the development of future treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Physical
Subila Kurukkal Balakrishnan, Priyakumari Chakkingal Parambil, Eran Edri
Summary: Metal trichalcogenides and chalcohalides are promising semiconducting materials with favorable optoelectronic properties. A synthetic strategy can transform trichalcogenides into chalcohalides. During the transformation, the crystal expands and unzips along the nanorod's z-axis, resulting in the formation of nanorods with a diameter of approximately 25% of the original crystals.
CHEMISTRY OF MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Dominique A. Doyle, Florencia N. Burian, Benjamin Aharoni, Annabelle J. Klinder, Melissa M. Menzel, Gerard Carlo C. Nifras, Ahad L. Shabazz-Henry, Bianca Ulrich Palma, Gisselle A. Hidalgo, Christopher J. Sottolano, Bianca M. Ortega, Matthew G. Niepielko
Summary: mRNA packaging into germ granules is a conserved strategy for posttranscriptional regulation of germline mRNAs. We studied the homotypic clustering of nos and pgc in four Drosophila species and found that clustering is a conserved process that enriches germ granule mRNAs. Natural variations in nos 3ʹ UTR sequence influence clustering, resulting in decreased nos levels and increased defective germ cells. Our findings highlight the impact of evolution on germ granules and provide insight into the diversity and regulation of biomolecular condensates.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Article
Engineering, Chemical
Huahua Fan, Xiaowa Nie, Chunshan Song, Xinwen Guo
Summary: Using density functional theory calculations, this study investigates the reaction networks and key steps in propane aromatization over Zn/ZSM-5 catalyst. The results show that Zn-Lewis acid sites play a crucial role in propane dehydrogenation, while propene aromatization proceeds under the combined action of Bronsted and Zn-Lewis acid sites. Moreover, introducing a second metal component can promote the removal of carbon deposits, leading to enhanced catalyst stability and more active sites for aromatization.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Lukasz Orzel, Maria Oszajca, Justyna Polaczek, Dominika Porebska, Rudi van Eldik, Grazyna Stochel
Summary: High pressure is a key parameter controlling chemical reaction kinetics, and combining high-pressure techniques with time-resolved spectroscopy provides a powerful tool for studying reaction mechanisms. This review focuses on the supporting role of high-pressure kinetic and spectroscopic methods in exploring nitric oxide bioinorganic chemistry, highlighting the importance of understanding interactions between nitric oxide and other reactive nitrogen species with biological targets.
Review
Cell Biology
Seoyoung Kim, Shaun E. Peterson, Maria Jasin, Scott Keeney
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Srilatha Simhadri, Shaun Peterson, Dharm S. Patel, Yanying Huo, Hong Cai, Christian Bowman-Colin, Shoreh Miller, Thomas Ludwig, Shridar Ganesan, Mantu Bhaumik, Samuel F. Bunting, Maria Jasin, Bing Xia
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Cell Biology
Shaun E. Peterson, Yinyin Li, Brian T. Chait, Max E. Gottesman, Richard Baer, Jean Gautier
JOURNAL OF CELL BIOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Lorene Rozier, Yige Guo, Shaun Peterson, Mai Sato, Richard Baer, Jean Gautier, Yinghui Mao
Article
Biochemistry & Molecular Biology
Shaun E. Peterson, Yinyin Li, Foon Wu-Baer, Brian T. Chait, Richard Baer, Hong Yan, Max E. Gottesman, Jean Gautier
Letter
Biochemistry & Molecular Biology
Shaun Peterson, Lily Wang, Kirsten Robertson, Geralda Torchon, Ouathek Ouerfelli, Jean Gautier
NATURE CHEMICAL BIOLOGY
(2009)
Article
Biochemistry & Molecular Biology
Cindy W. Fung, Gary S. Fortin, Shaun E. Peterson, Lorraine S. Symington
MOLECULAR AND CELLULAR BIOLOGY
(2006)
Article
Dermatology
HY Park, J Lee, S Gonzalez, MA Middelkamp-Hup, S Kapasi, S Peterson, BA Gilchrest
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2004)