SLC7A11/ xCT is a target of miR-5096 and its restoration partially rescues miR-5096-mediated ferroptosis and anti-tumor effects in human breast cancer cells

xCT-Driven Expression of GPX4 Determines Sensitivity of Breast Cancer Cells to Ferroptosis Inducers

(2021) Namgyu Lee et al.   Antioxidants

A Novel Ferroptosis-Related Gene Signature Predicts Overall Survival of Breast Cancer Patients

(2021) Haifeng Li et al.   Biology-Basel

A facile colorimetric method for the quantification of labile iron pool and total iron in cells and tissue specimens

(2021) Usama Abbasi et al.   Scientific Reports

ROS in cancer therapy: the bright side of the moon

(2020) Bruno Perillo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

MicroRNA‐214‐3p enhances erastin‐induced ferroptosis by targeting ATF4 in hepatoma cells

(2020) Tao Bai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase

(2020) Ji Cao et al.   Nature Communications

Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice

(2020) Mami Sato et al.   INTERNATIONAL JOURNAL OF CANCER

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

(2020) Pranavi Koppula et al.   Protein & Cell

Targeting AGTR1/NF-κB/CXCR4 axis by miR-155 attenuates oncogenesis in glioblastoma

(2020) Anukriti Singh et al.   NEOPLASIA

Iron Metabolism in Ferroptosis

(2020) Xin Chen et al.   Frontiers in Cell and Developmental Biology

Targeting ferroptosis for cancer therapy: exploring novel strategies from its mechanisms and role in cancers

(2020) Minlin Jiang et al.   Translational Lung Cancer Research

A feedback loop between miRNA-155, Programmed cell death 4 and Activation Protein-1 modulates the expression of miR-155 and tumorigenesis in tongue cancer

(2019) Shabir Zargar et al.   MOLECULAR AND CELLULAR BIOLOGY

xCT knockdown in human breast cancer cells delays onset of cancer-induced bone pain

(2019) Robert G Ungard et al.   Molecular Pain

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

(2019) Giovanni C. Forcina et al.   PROTEOMICS

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance

(2019) Jonathan K. M. Lim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cystine–glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity

(2019) Michael D. Arensman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors

(2019) Christopher Fitzpatrick et al.   Cell Death & Disease

Chemoresistance mechanisms of breast cancer and their countermeasures

(2019) Xiwei Ji et al.   BIOMEDICINE & PHARMACOTHERAPY

Ferroptosis Accompanied by •OH Generation and Cytoplasmic Viscosity Increase Revealed via Dual-Functional Fluorescence Probe

(2019) Hongyu Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma

(2019) Kewen Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma

(2018) Meiying Luo et al.   CELL DEATH AND DIFFERENTIATION

xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression

(2018) Xiangming Ji et al.   ONCOGENE

Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma

(2018) Masaki Nagane et al.   PLoS One

Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

(2018) Yun Sun et al.   Cell Death & Disease

miR-9 regulates ferroptosis by targeting glutamic-oxaloacetic transaminase GOT1 in melanoma

(2018) Kexin Zhang et al.   MOLECULAR CARCINOGENESIS

Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo

(2018) Seung-Shick Shin et al.   Oncogenesis

Iron accumulation, glutathione depletion, and lipid peroxidation must occur simultaneously during ferroptosis and are mutually amplifying events

(2017) Robert L. Bertrand   MEDICAL HYPOTHESES

Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells

(2017) Emmanuel Dornier et al.   Nature Communications

Modulation of the inwardly rectifying potassium channel Kir4.1 by the pro-invasive miR-5096 in glioblastoma cells

(2017) Dominique Thuringer et al.   Oncotarget

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses

(2017) Darshan S. Chandrashekar et al.   NEOPLASIA

The down-regulation of SLC7A11 enhances ROS induced P-gp over-expression and drug resistance in MCF-7 breast cancer cells

(2017) Chun Ge et al.   Scientific Reports

MiR-26b inhibits melanoma cell proliferation and enhances apoptosis by suppressing TRAF5-mediated MAPK activation

(2016) Meng Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-214 suppresses growth, migration and invasion through a novel target, high mobility group AT-hook 1, in human cervical and colorectal cancer cells

(2016) Karthik Subramanian Chandrasekaran et al.   BRITISH JOURNAL OF CANCER

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Downregulation of HMGB1 by miR-34a is sufficient to suppress proliferation, migration and invasion of human cervical and colorectal cancer cells

(2016) Karthik Subramanian Chandrasekaran et al.   TUMOR BIOLOGY

Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells

(2016) S Ma et al.   Cell Death & Disease

Transfer of functional microRNAs between glioblastoma and microvascular endothelial cells through gap junctions

(2016) Dominique Thuringer et al.   Oncotarget

Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis

(2016) Tina Sehm et al.   Oncotarget

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

HSPB1 as a novel regulator of ferroptotic cancer cell death

(2015) X Sun et al.   ONCOGENE

Reduced Expression of miRNA-27a Modulates Cisplatin Resistance in Bladder Cancer by Targeting the Cystine/Glutamate Exchanger SLC7A11

(2014) R. M. Drayton et al.   CLINICAL CANCER RESEARCH

Widespread context dependency of microRNA-mediated regulation

(2014) F. Erhard et al.   GENOME RESEARCH

Autophagy as a modulator and target in prostate cancer

(2014) Jason M. Farrow et al.   Nature Reviews Urology

ColonyArea: An ImageJ Plugin to Automatically Quantify Colony Formation in Clonogenic Assays

(2014) Camilo Guzmán et al.   PLoS One

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

Long Chain Fatty Acyl-CoA Synthetase 4 Is a Biomarker for and Mediator of Hormone Resistance in Human Breast Cancer

(2013) Xinyu Wu et al.   PLoS One

Evading apoptosis in cancer

(2013) Kaleigh Fernald et al.   TRENDS IN CELL BIOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11

(2011) Xiao-Xiao Liu et al.   FEBS LETTERS

Solute carrier protein family may involve in radiation-induced radioresistance of non-small cell lung cancer

(2011) Li Xie et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Extracellular thiol-assisted selenium uptake dependent on the xc- cystine transporter explains the cancer-specific cytotoxicity of selenite

(2009) E. Olm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of doxorubicin-induced cardiac injury by mitochondrial glutaredoxin 2

(2008) Nicole M. Diotte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/β-catenin pathway

(2008) R-S Chen et al.   ONCOGENE