Cytotoxic mechanisms of doxorubicin at clinically relevant concentrations in breast cancer cells
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Title
Cytotoxic mechanisms of doxorubicin at clinically relevant concentrations in breast cancer cells
Authors
Keywords
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Journal
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-02-12
DOI
10.1007/s00280-022-04400-y
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Note: Only part of the references are listed.- A novel method to detect intracellular metabolite alterations in MCF-7 cells by doxorubicin induced cell death
- (2021) Ajay Kumar et al. Metabolomics
- Total, renal and hepatic clearances of doxorubicin and formation clearance of doxorubicinol in patients with breast cancer: Estimation of doxorubicin hepatic extraction ratio
- (2020) Leandro Francisco Pippa et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Sarcopenia and Heart Failure
- (2020) Francesco Curcio et al. Nutrients
- Mutant p53-Associated Molecular Mechanisms of ROS Regulation in Cancer Cells
- (2020) Marco Cordani et al. Biomolecules
- New insights into the activities and toxicities of the old anticancer drug doxorubicin
- (2020) Sabina Y. van der Zanden et al. FEBS Journal
- Doxorubicin-induced p53 interferes with mitophagy in cardiac fibroblasts
- (2020) T. R. Mancilla et al. PLoS One
- Laccase as an efficacious approach to remove anticancer drugs: A study of doxorubicin degradation, kinetic parameters, and toxicity assessment
- (2020) Maikon Kelbert et al. JOURNAL OF HAZARDOUS MATERIALS
- Breast Cancer Treatment
- (2019) Adrienne G. Waks et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- FBS/BSA media concentration determines CCCP’s ability to depolarize mitochondria and activate PINK1-PRKN mitophagy
- (2019) Marc P. M. Soutar et al. Autophagy
- Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities
- (2019) Donglu Zhang et al. DRUG METABOLISM AND DISPOSITION
- Insights into Doxorubicin-induced Cardiotoxicity: Molecular Mechanisms, Preventive Strategies, and Early Monitoring
- (2019) Nadine Wenningmann et al. MOLECULAR PHARMACOLOGY
- Pharmacokinetics and cardiotoxicity of doxorubicin and its secondary alcohol metabolite in rats
- (2019) Xiaofang Zeng et al. BIOMEDICINE & PHARMACOTHERAPY
- p53 prevents doxorubicin cardiotoxicity independently of its prototypical tumor suppressor activities
- (2019) Jie Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Decreased Activity of Blood Acid Sphingomyelinase in the Course of Multiple Myeloma
- (2019) Marzena Wątek et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Intracellular trafficking and cytotoxicity of a gelatine–doxorubicin conjugate in two breast cancer cell lines
- (2019) Mohammed M. Alvi et al. JOURNAL OF DRUG TARGETING
- An update on the mechanisms related to cell death and toxicity of doxorubicin and the protective role of nutrients
- (2019) Alfonso Varela-López et al. FOOD AND CHEMICAL TOXICOLOGY
- Lysosomal membrane permeabilization as a cell death mechanism in cancer cells
- (2018) Ana Serrano-Puebla et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Low-dose doxorubicin with carotenoids selectively alters redox status and upregulates oxidative stress-mediated apoptosis in breast cancer cells
- (2018) Kariyappa Vijay et al. FOOD AND CHEMICAL TOXICOLOGY
- Effect of the FE 2+ chelation by 2,2′-dipyridyl in the doxorubicin-induced lethality in breast tumor cell lines
- (2018) Jéssica R. Bernardes et al. LIFE SCIENCES
- Integration of Ca2+ signaling regulates the breast tumor cell response to simvastatin and doxorubicin
- (2018) Souleymane Abdoul-Azize et al. ONCOGENE
- Lysosomal membrane permeabilization and cell death
- (2018) Fengjuan Wang et al. TRAFFIC
- Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives
- (2018) Jessica Marinello et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Doxorubicin-induced heart failure in cancer patients: A cohort study based on the Korean National Health Insurance Database
- (2018) Young Ae Kim et al. Cancer Medicine
- ROS and the DNA damage response in cancer
- (2018) Upadhyayula Sai Srinivas et al. Redox Biology
- The manganese(III) porphyrin MnTnHex-2-PyP5+ modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells
- (2018) Ana Flórido et al. Redox Biology
- Molecular Mechanisms of Cardiotoxicity: A Review on Major Side-effect of Doxorubicin
- (2017) M Mobaraki et al. INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicity
- (2017) André Ferreira et al. TOXICOLOGY
- Strategies for the evaluation of DNA damage and repair mechanisms in cancer
- (2017) Gabriela Figueroa-González et al. Oncology Letters
- A role for caspase-2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells - implications for the CHK1-suppressed pathway
- (2017) Brittany L. Carroll et al. FEBS Open Bio
- Influence of doxorubicin on apoptosis and oxidative stress in breast cancer cell lines
- (2016) Nesstor Pilco-Ferreto et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Increasing role of the cancer chemotherapeutic doxorubicin in cellular metabolism
- (2016) Ann-Marie Meredith et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Deficiency in Cardiolipin Reduces Doxorubicin-Induced Oxidative Stress and Mitochondrial Damage in Human B-Lymphocytes
- (2016) Baikuntha Aryal et al. PLoS One
- Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease
- (2016) Valentina Cappello et al. Scientific Reports
- Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines
- (2015) Derek Edwardson et al. CURRENT DRUG METABOLISM
- Mitochondrial biogenesis and dynamics in the developing and diseased heart
- (2015) Gerald W. Dorn et al. GENES & DEVELOPMENT
- Three-dimensional microenvironment confers enhanced sensitivity to doxorubicin by reducing p53-dependent induction of autophagy
- (2015) L R Gomes et al. ONCOGENE
- Oxidative stress induced by low-dose doxorubicin promotes the invasiveness of osteosarcoma cell line U2OS in vitro
- (2015) Seung Han Shin et al. TUMOR BIOLOGY
- P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest
- (2015) A A Shamseddine et al. Cell Death & Disease
- Involvement of p53 in insulin-like growth factor binding protein-3 regulation in the breast cancer cell response to DNA damage
- (2015) Kamila A. Marzec et al. Oncotarget
- Editorial: Radiation-induced and oxidative DNA damages
- (2015) Antonio Monari et al. Frontiers in Chemistry
- Polymer conjugates of doxorubicin bound through an amide and hydrazone bond: Impact of the carrier structure onto synergistic action in the treatment of solid tumours
- (2014) Tomáš Etrych et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- DNA topoisomerases in mtDNA maintenance and ageing
- (2014) Stefan Sobek et al. EXPERIMENTAL GERONTOLOGY
- Doxorubicin, DNA torsion, and chromatin dynamics
- (2013) Fan Yang et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin
- (2013) Wojciech M. Ciszewski et al. BREAST CANCER RESEARCH AND TREATMENT
- Distribution of the anticancer drugs doxorubicin, mitoxantrone and topotecan in tumors and normal tissues
- (2013) Krupa J. Patel et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Population pharmacokinetics of doxorubicin: establishment of a NONMEM model for adults and children older than 3 years
- (2013) Nina E. Kontny et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Lysosomal cell death at a glance
- (2013) S. Aits et al. JOURNAL OF CELL SCIENCE
- Adsorption and Degradation of Doxorubicin from Aqueous Solution in Polypropylene Containers
- (2012) Darren C. Wu et al. AAPS PHARMSCITECH
- Loss of O6-methylguanine-DNA methyltransferase confers collateral sensitivity to carmustine in topoisomerase II-mediated doxorubicin resistant triple negative breast cancer cells
- (2012) Selina Raguz et al. BIOCHEMICAL PHARMACOLOGY
- Telomere dysfunction induced by chemotherapeutic agents and radiation in normal human cells
- (2012) Ping Li et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies
- (2012) Yanti Octavia et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Identification of the molecular basis of doxorubicin-induced cardiotoxicity
- (2012) Sui Zhang et al. NATURE MEDICINE
- Disruption of a GATA4/Ankrd1 Signaling Axis in Cardiomyocytes Leads to Sarcomere Disarray: Implications for Anthracycline Cardiomyopathy
- (2012) Billy Chen et al. PLoS One
- Doxorubicin Influences the Expression of Glucosylceramide Synthase in Invasive Ductal Breast Cancer
- (2012) Xiaofang Zhang et al. PLoS One
- Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage
- (2010) Andrea Huwiler et al. BRITISH JOURNAL OF PHARMACOLOGY
- Pharmacokinetic evaluation of doxorubicin plasma levels in normal and overweight patients with breast cancer and simulation of dose adjustment by different indexes of body mass
- (2010) Deise Raquel Barpe et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Analysis of intracellular doxorubicin and its metabolites by ultra-high-performance liquid chromatography
- (2010) Kumiko Sakai-Kato et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Chemotherapy for breast cancer (Review)
- (2010) Hassan ONCOLOGY REPORTS
- Doxorubicin pathways
- (2010) Caroline F. Thorn et al. Pharmacogenetics and Genomics
- Mechanisms of Anthracycline Cardiac Injury: Can We Identify Strategies for Cardioprotection?
- (2010) Douglas B. Sawyer et al. PROGRESS IN CARDIOVASCULAR DISEASES
- Concerning Chapter 5 – Human Albumin; in Cross-Sectional Guidelines for Therapy with Blood Components and Plasma Derivatives, 4th ed. Transfus Med Hemother 2009;36(6):399–407
- (2010) Albert Farrugia TRANSFUSION MEDICINE AND HEMOTHERAPY
- Cardiomyocyte death in doxorubicin-induced cardiotoxicity
- (2009) Yi-Wei Zhang et al. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
- A concise description of cardioprotective strategies in doxorubicin-induced cardiotoxicityThis article is one of a selection of papers published in a special issue celebrating the 125th anniversary of the Faculty of Medicine at the University of Manitoba.
- (2009) Ana R. Lehenbauer Ludke et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Doxorubicin: The Good, the Bad and the Ugly Effect
- (2009) Cristina Carvalho et al. CURRENT MEDICINAL CHEMISTRY
- 3′-Deoxy-3′-[18F]fluorothymidine (FLT) uptake in breast cancer cells as a measure of proliferation after doxorubicin and docetaxel treatment
- (2009) Helmut Dittmann et al. NUCLEAR MEDICINE AND BIOLOGY
- Lysosomal Targeting and Trafficking of Acid Sphingomyelinase to Lipid Raft Platforms in Coronary Endothelial Cells
- (2008) Si Jin et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- A role for ceramide in driving cancer cell resistance to doxorubicin
- (2008) Yong-Yu Liu et al. FASEB JOURNAL
- ROS and p53: A versatile partnership
- (2008) Bin Liu et al. FREE RADICAL BIOLOGY AND MEDICINE
- TVP1022 and Propargylamine Protect Neonatal Rat Ventricular Myocytes Against Doxorubicin-Induced and Serum Starvation-Induced Cardiotoxicity
- (2008) Yana Kleiner et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Doxorubicin, Cardiac Risk Factors, and Cardiac Toxicity in Elderly Patients With Diffuse B-Cell Non-Hodgkin's Lymphoma
- (2008) Dawn L. Hershman et al. JOURNAL OF CLINICAL ONCOLOGY
- Detection of Adriamycin-DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations
- (2008) K. E. Coldwell et al. NUCLEIC ACIDS RESEARCH
- The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing
- (2008) J. E. Deweese et al. NUCLEIC ACIDS RESEARCH
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