Review
Neurosciences
Junxuan Lyu, Di Xie, Tarun N. Bhatia, Rehana K. Leak, Xiaoming Hu, Xiaoyan Jiang
Summary: The article discusses the roles of microglia and macrophages in the neuropathological processes of stroke patients, as well as their functions in brain injury and repair. Additionally, it summarizes current breakthroughs in therapeutic strategies that modulate microglia and macrophage responses.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Plant Sciences
Yehao Zhang, Lan Miao, Qing Peng, Xiaodi Fan, Wenting Song, Bin Yang, Peng Zhang, Guangyu Liu, Jianxun Liu
Summary: The study demonstrates that Parthenolide (PTL) can regulate neuroinflammation and protect against ischemic brain injury by modulating microglial polarization via the RhoA/ROCK pathway.
Article
Immunology
Jinqing Lai, Genwang Chen, Zhe Wu, Shaoyang Yu, Rongfu Huang, Yile Zeng, Weibin Lin, Chunmei Fan, Xiangrong Chen
Summary: PHLDA1 plays a crucial role in the immune response after SAH by balancing microglia M1/M2 polarization and suppressing NLRP3 inflammasome signaling, which reduces neuroinflammation, neuronal apoptosis, and improves neurological outcomes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Zixuan Lin, Chen Chen, Dongqin Yang, Jianqing Ding, Guanghui Wang, Haigang Ren
Summary: DJ-1 plays a crucial role in neuroinflammation by facilitating the interaction between IκBα and p65 in microglia, resulting in the repression of microglial activation and the protection of DA neurons from inflammation-induced injury in Parkinson's disease.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Chaoming Liu, Song Liu, Lijiao Xiong, Limei Zhang, Xiao Li, Xingling Cao, Jinhua Xue, Liangdong Li, Cheng Huang, Zhihua Huang
Summary: The study demonstrated that GSS protected against brain injury in ischemic stroke by reducing microglial M1 depolarization to suppress neuroinflammation in peri-infarcted brain regions through upregulating alpha 7nAChR and thereby inhibition of NF-KB signaling. This finding reveals a potential molecular mechanism for GSS treatment in ischemic stroke.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Immunology
Junjie Cheng, Rong Zhang, Zhirou Xu, Youliang Ke, Renjuan Sun, Huicui Yang, Xiaohu Zhang, Xuechu Zhen, Long-Tai Zheng
Summary: The study suggests that glycolysis plays a crucial role in microglial activation and inhibiting glycolysis can attenuate neuroinflammatory diseases associated with microglial activation.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Medicine, Research & Experimental
Xiangxiu Chen, Junshu Xue, Junjie Zou, Xinghong Zhao, Lixia Li, Renyong Jia, Yuanfeng Zou, Hongping Wan, Yaqin Chen, Xun Zhou, Gang Ye, Lizi Yin, Xiaoxia Liang, Changliang He, Ling Zhao, Huaqiao Tang, Cheng Lv, Xu Song, Zhongqiong Yin
Summary: This study demonstrated that Resveratrol (Res) could protect mice from pseudorabies virus-induced encephalitis by regulating microglia polarization and neuronal apoptosis. Res reduced blood-brain barrier permeability in PRV-infected mice and decreased the expressions of MMP-2, MMP-9, and ZO-1 in the cortex. It also inhibited the expressions of pro-inflammatory factors and chemokines while increasing the expressions of anti-inflammatory factors and neurotrophic factor in the brain. In vitro experiments showed that Res suppressed M1 microglia polarization and activated M2 microglia polarization. Co-culture experiments indicated that Res alleviated inflammatory response and neuronal apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Donghai Li, Tianpeng He, Yue Zhang, Junru Liu, Haiyu Zhao, Dongliang Wang, Quanchao Wang, Shengxiang Zhang, Yuan Yuan
Summary: Ischemic stroke is a major cause of death and disability globally, with neuroinflammation playing a key role in its development. Microglia, the primary immune cells in the brain, undergo rapid activation and polarization following ischemic stroke, which is crucial in regulating the inflammatory response. Melatonin, a promising neuroprotective agent, can regulate microglial polarization in central nervous system diseases, but its specific mechanism in protecting against ischemic stroke-induced brain injury remains unclear.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xuejun He, Yimin Huang, Yuan Liu, Xincheng Zhang, Quanji Wang, Yanchao Liu, Xiaopeng Ma, Xiaobing Long, Yang Ruan, Hongxia Lei, Chao Gan, Xiaochuan Wang, Xin Zou, Bo Xiong, Kai Shu, Ting Lei, Huaqiu Zhang
Summary: This study revealed that an exosomal long non-coding RNA from astrocytes attenuates microglial activation after traumatic brain injury by up-regulating Smad7, providing a potential therapeutic target.
Article
Immunology
Haijian Wu, Jingwei Zheng, Shenbin Xu, Yuanjian Fang, Yingxi Wu, Jianxiong Zeng, Anwen Shao, Ligen Shi, Jianan Lu, Shuhao Mei, Xiaoyu Wang, Xinying Guo, Yirong Wang, Zhen Zhao, Jianmin Zhang
Summary: Mer plays an important role in regulating microglial/macrophage M1/M2 polarization and neuroinflammation following TBI, potentially serving as a therapeutic target for intervention. Activation of the STAT1/SOCS1/3 pathway by Mer contributes to its regulatory function in this process.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Pharmacology & Pharmacy
Shan He, Shangshang Wang, Suqing Liu, Zheng Li, Xiao Liu, Jinfeng Wu
Summary: Baicalein inhibits tumor growth by promoting M1-like macrophage polarization, which is partly mediated through the PI3K gamma/NF-kappa B signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Lingqi Kong, Wenyu Li, E. Chang, Wuxuan Wang, Nan Shen, Xiang Xu, Xinyue Wang, Yan Zhang, Wen Sun, Wei Hu, Pengfei Xu, Xinfeng Liu
Summary: This study demonstrates that STING, activated by mtDNA, promotes microglial polarization towards the M1 phenotype following ischemic stroke. Inhibition of STING may serve as a potential therapeutic strategy to mitigate neuroinflammation and improve stroke outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Chin-Hung Hsu, Yi-Ju Pan, Yin-Ting Zheng, Raymond Y. Lo, Feng-Yi Yang
Summary: This study investigated the effects of low-intensity pulsed ultrasound (LIPUS) on M1/M2 polarization of microglial cells and the regulatory mechanisms associated with signaling pathways. The results showed that LIPUS treatment attenuated inflammatory markers and enhanced M2-related markers, switching microglial cells from the M1 to the M2 phenotype.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cell Biology
Tuo Li, Lei Li, Ruilong Peng, Hongying Hao, Hejun Zhang, Yalong Gao, Cong Wang, Fanjian Li, Xilei Liu, Fanglian Chen, Shu Zhang, Jianning Zhang
Summary: This study investigates the neuroprotective effects of abrocitinib in traumatic brain injury models. The results show that abrocitinib can reduce inflammatory cell infiltration and levels of inflammatory cytokines, improve neurological function, and enhance blood-brain barrier function.
Article
Biochemistry & Molecular Biology
Yeo Jin Park, Hye Jin Yang, Wei Li, You-Chang Oh, Younghoon Go
Summary: In this study, the effects of Menthae Herba (MH) on the inflammatory response and molecular mechanisms in activated microglia were evaluated. The results showed that MH inhibited the production of proinflammatory enzymes and mediators, reduced reactive oxygen species (ROS) levels, and activated antioxidant signaling pathways. These findings suggest the potential therapeutic use of MH in neuroinflammatory diseases.
Article
Computer Science, Artificial Intelligence
Jianing Xi, Zhaoji Miao, Longzhong Liu, Xuebing Yang, Wensheng Zhang, Qinghua Huang, Xuelong Li
Summary: The proposed framework KTEAED demonstrates promising performance in diagnosing breast ultrasound samples with limited labels, by achieving global representation of KG entities/relations and enhancing associations to predict clinical outcomes.
Article
Pharmacology & Pharmacy
Luyuan Niu, Zongjian Liu, Xue Geng, Xuanshu Zhong, Hui Zhao, Huan Zhang, Jianing Xi, Zengguo Feng, Fuxian Zhang, Lin Ye
Summary: The drug eluting retrievable vena cava filter (RVCF) prepared in this study showed excellent antihyperplasia properties, significantly improving the retrieval rate and dwelling time in vivo. It has promising potential for clinical application.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Computer Science, Interdisciplinary Applications
Yifan Gu, Xuebing Yang, Lei Tian, Hongyu Yang, Jicheng Lv, Chao Yang, Jinwei Wang, Jianing Xi, Guilan Kong, Wensheng Zhang
Summary: Patient similarity learning is crucial in biomedical informatics, and this paper proposes a novel deep learning framework called SSGNet, which utilizes graph neural networks to capture the intrinsic relationships between patients and mitigate the impact of missing values. Extensive experiments on various datasets demonstrate that SSGNet outperforms baseline methods and achieves significant improvement in patient similarity classification and encounter retrieval tasks.
JOURNAL OF BIOMEDICAL INFORMATICS
(2022)
Article
Medicine, General & Internal
Chen Wu, Yu-Xuan Liu, Tie-Jun Liu, Xu-Ling Yan, Yu-Xi Zhao, Hong Zeng, Tian Zhou, Ping Rao, Lan-Ying Sun, Yang Jiao, Jia-Ning Xi
Summary: This study investigates the well-being level of elderly people with chronic diseases in Beijing during the postpandemic period of COVID-19 and identifies factors that influence their well-being. The study found that education level, number of chronic diseases, medical expenses, frequency of children's visits, and participation in group activities significantly affect the well-being of these patients. Most elderly patients with chronic diseases had moderate or above well-being levels during the postpandemic period, but attention should be given to those with low education level, multiple comorbidities, higher medical expenses, fewer visits by children, and lack of participation in group activities.
Article
Mathematics
Yu Liu, Qiang Wang, Jianing Xi
Summary: Protein lysine acetylation is an important post-translational modification that plays a crucial role in cellular processes. Recent studies have shown that acetylation sites vary across species, but there is currently no integrated prediction model for acetylation sites across all species. This study proposes a domain adaptation framework called DeepDA-Ace, which utilizes attention-based convolutional neural networks and semantic adversarial learning for species-specific acetylation site prediction. Results demonstrate that DeepDA-Ace outperforms general prediction models and fine-tuning based species-specific models, with precision exceeding 0.75 for most species and at least 5% improvement over existing prediction tools.
Article
Engineering, Biomedical
Jianing Xi, Dan Wang, Xuebing Yang, Wensheng Zhang, Qinghua Huang
Summary: This research analyzes the importance of explainable AI drug recommendation and proposes a traceability rate as an evaluation metric, which shows a trade-off between model performance and explainability.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Clinical Neurology
Keke Chen, Zhaohui Jin, Jinping Fang, Lin Qi, Cui Liu, Ruidan Wang, Yuan Su, Hongjiao Yan, Aixian Liu, Jianing Xi, Qiping Wen, Boyan Fang
Summary: This study investigated the relationship between cerebral small vessel disease (CSVD) burden and its imaging markers and alterations in different gait parameters in Parkinson's disease (PD). It was found that greater CSVD burden was associated with poor attention, impaired executive function, and slow gait speed. Different imaging markers also played a role in gait and cognitive dysfunction in PD.
NEUROLOGICAL SCIENCES
(2023)
Article
Behavioral Sciences
Keke Chen, Zhaohui Jin, Jinping Fang, Lin Qi, Cui Liu, Ruidan Wang, Yuan Su, Hongjiao Yan, Aixian Liu, Jianing Xi, Boyan Fang
Summary: This study investigated the associations between lacunes, cognition, and motor function in patients with Parkinson's disease (PD) and found that lacunes were independently associated with worse visual scanning, attention, and processing speed. The presence of lacunes was also found to be related to longer completion time of the Trail-Making Test part A (TMT-A) and slower gait speed in PD patients. Early treatment of vascular disease may mitigate motor and cognitive dysfunction in PD patients and potentially slow down the progression of the disease.
BRAIN AND BEHAVIOR
(2023)
Article
Multidisciplinary Sciences
Jianing Xi, Zhen Deng, Yang Liu, Qian Wang, Wen Shi
Summary: Driver event discovery is important for breast cancer diagnosis and therapy, especially in determining subtype-specific drivers for personalized biomarker discovery and precision treatment. However, most existing studies mainly focus on DNA aberrations and gene interactions, and the integration of multi-type aberrations from both DNA and RNA remains a challenge for breast cancer drivers.
Article
Chemistry, Multidisciplinary
Zhuowei Li, Junlin Wang, Yanyu Deng, Jianing Xi, Yi Zhang, Chunyu Liu, Wenbin Guo
Summary: To commercialize CsPbI2Br-based perovskite solar cells (PSCs), stability issues induced by the hygroscopic nature of spiro-OMeTAD and residual strain of the perovskite layer need to be addressed. This study shows that by using PCPDTBT as a p-type semiconductor, the issues of hole transport and strain regulation can be overcome. The CsPbI2Br-based PSCs with PCPDTBT layer achieved an improved efficiency of 16.5% and enhanced stability.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Environmental
Xiaoyu Ma, Fuhai Gao, Wei Su, Yuanyuan Ran, Tuerhong Bilalijiang, Yerasel Tuolhen, Guiqin Tian, Lin Ye, Zengguo Feng, Jianing Xi, Zongjian Liu
Summary: A precursor solution loaded with BDNF and VEGF is injected into the brain cavity of a stroke mouse induced by the photothrombotic method to form a multifunctional hydrogel. BDNF and VEGF are sustainably released from the hydrogel, promoting angiogenesis and neuroplasticity. The hydrogel also modulates microglial polarization and enhances motor recovery in stroke mice.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biology
Jianing Xi, Donghui Sun, Cai Chang, Shichong Zhou, Qinghua Huang
Summary: Radiogenomics analysis can infer the genomic features of tumors from their radiogenomic associations through low-cost and non-invasive screening ultrasonic images, providing connections between genomics and radiomics. Existing studies mainly focus on the relationship between ultrasonic features and popular cancer genes, but overlook the many-to-many relationships and sample associations with tumor heterogeneity. To address these challenges, we propose an omics-to-omics joint knowledge association subtensor model that discovers cross-modal modules and identifies sample subgroups. Experimental results demonstrate the jointness of discovered modules, their association with tumorigenesis contribution, and their relation to cancer-related functions. In conclusion, our proposed model can effectively facilitate radiogenomic knowledge associations and promote the construction of explainable AI cancer diagnosis.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Neurosciences
Yinan Duan, Yixuan Wang, Yonghong Liu, Zhaohui Jin, Cui Liu, Xin Yu, Keke Chen, Detao Meng, Jianing Xi, Boyan Fang
Summary: This study analyzed the differentially expressed circRNAs in peripheral blood exosomes between Parkinson's disease (PD) patients and healthy controls (HCs), and investigated the influence of rehabilitation on circRNAs to explore competing RNA networks and epigenetic mechanisms. The results showed significant differences in circRNAs expression between PD patients and HCs, as well as changes in circRNAs expression after rehabilitation. Functional enrichment analysis revealed the potential impact of differentially expressed circRNAs on cellular actin backbone stability and synaptic structure. Validation experiments confirmed the reduced expression levels of selected circRNAs after rehabilitation. The findings suggest that rehabilitation can mitigate the pathological process of PD through epigenetic means.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Clinical Neurology
Zhi-Quan Yang, Meng-Fan Wei, Lin Chen, Jia-Ning Xi
Summary: Restoration of walking ability in stroke patients is crucial for their reintegration into their families and society. Motor-cognitive dual-task training (MCDTT) can effectively enhance the functional network connection between motor and cognitive brain regions, leading to brain functional network remodeling. Compared to single-task training, MCDTT is more relevant to daily life and can more effectively improve stroke patients' adaptive walking ability. This paper summarizes the application and research progress of MCDTT in post-stroke walking rehabilitation and aims to establish a theoretical basis for further research on systematic motor-cognitive therapy techniques to promote walking rehabilitation in stroke patients.
JOURNAL OF NEURORESTORATOLOGY
(2023)
Letter
Critical Care Medicine
Qing Li, Yi Li, Guangyu Niu, Mingna Li, Jia Deng, Knut Moeller, Inez Frerichs, Jianing Xi, Hongying Jiang, Zhanqi Zhao
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
