Microglial glutaminase 1 deficiency mitigates neuroinflammation associated depression

Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders

(2021) Yoshikazu Johmura et al.   SCIENCE

Brief postpartum separation from offspring promotes resilience to lipopolysaccharide challenge-induced anxiety and depressive-like behaviors and inhibits neuroinflammation in C57BL/6J dams

(2021) Zuotian Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

Folic Acid Inhibits Aging-Induced Telomere Attrition and Apoptosis in Astrocytes In Vivo and In Vitro

(2021) Zhenshu Li et al.   CEREBRAL CORTEX

Astrocyte-derived extracellular vesicles: A double-edged sword in central nervous system disorders

(2021) Shu Zhao et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Glutaminase 1 Regulates Neuroinflammation After Cerebral Ischemia Through Enhancing Microglial Activation and Pro-Inflammatory Exosome Release

(2020) Ge Gao et al.   Frontiers in Immunology

Neuroinflammation and depression: A review

(2020) Romain Troubat et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation

(2020) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

Disease-associated astrocytes in Alzheimer’s disease and aging

(2020) Naomi Habib et al.   NATURE NEUROSCIENCE

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

(2020) Insup Choi et al.   Nature Communications

Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia

(2020) Peter L. Wang et al.   Nature Communications

Glutamine Antagonist JHU-083 Normalizes Aberrant Hippocampal Glutaminase Activity and Improves Cognition in APOE4 Mice

(2020) Kristen R. Hollinger et al.   JOURNAL OF ALZHEIMERS DISEASE

Glutaminase in microglia: A novel regulator of neuroinflammation

(2020) Lu Ding et al.   BRAIN BEHAVIOR AND IMMUNITY

Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression

(2020) Weifen Li et al.   BRAIN BEHAVIOR AND IMMUNITY

Postmortem transcriptional profiling reveals widespread increase in inflammation in schizophrenia: a comparison of prefrontal cortex, striatum, and hippocampus among matched tetrads of controls with subjects diagnosed with schizophrenia, bipolar or major depressive disorder

(2019) Thomas A. Lanz et al.   Translational Psychiatry

Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

(2019) Marta Lombardi et al.   ACTA NEUROPATHOLOGICA

Microglial production of quinolinic acid as a target and a biomarker of the antidepressant effect of ketamine

(2019) Franck Verdonk et al.   BRAIN BEHAVIOR AND IMMUNITY

CSF-1 controls cerebellar microglia and is required for motor function and social interaction

(2019) Veronika Kana et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glutaminase C Regulates Microglial Activation and Pro-inflammatory Exosome Release: Relevance to the Pathogenesis of Alzheimer’s Disease

(2019) Ge Gao et al.   Frontiers in Cellular Neuroscience

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

(2019) Amit U. Joshi et al.   NATURE NEUROSCIENCE

Microglial activation contributes to depressive-like behavior in dopamine D3 receptor knockout mice

(2019) Jing Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior

(2018) Eric S. Wohleb et al.   BIOLOGICAL PSYCHIATRY

Glutaminase 1 regulates the release of extracellular vesicles during neuroinflammation through key metabolic intermediate alpha-ketoglutarate

(2018) Beiqing Wu et al.   Journal of Neuroinflammation

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

(2018) Sofie Voet et al.   Nature Communications

Ouabain attenuates oxidative stress and modulates lipid composition in hippocampus of rats in lipopolysaccharide-induced hypocampal neuroinflammation in rats

(2018) Israel José Pereira Garcia et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model

(2018) Giuseppe Locatelli et al.   NATURE NEUROSCIENCE

JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress

(2018) Xiaolei Zhu et al.   NEUROPSYCHOPHARMACOLOGY

Inference of cell type content from human brain transcriptomic datasets illuminates the effects of age, manner of death, dissection, and psychiatric diagnosis

(2018) Megan Hastings Hagenauer et al.   PLoS One

GLS1 Mutant Mice Display Moderate Alterations of Hippocampal Glutamatergic Neurotransmission Associated with Specific Adaptive Behavioral Changes

(2018) Patrick Dutar et al.   NEUROSCIENCE

Microglia and early brain development: An intimate journey

(2018) Morgane S. Thion et al.   SCIENCE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Post-mortem molecular profiling of three psychiatric disorders

(2017) Ryne C. Ramaker et al.   Genome Medicine

Dopamine neuron dependent behaviors mediated by glutamate cotransmission

(2017) Susana Mingote et al.   eLife

Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior

(2016) Yuyan Cheng et al.   BRAIN BEHAVIOR AND IMMUNITY

Protective Effects of Glutamine Antagonist 6-Diazo-5-Oxo-l-Norleucine in Mice with Alphavirus Encephalomyelitis

(2016) Sivabalan Manivannan et al.   JOURNAL OF VIROLOGY

Immune and Neuroendocrine Mechanisms of Stress Vulnerability and Resilience

(2016) Caroline Ménard et al.   NEUROPSYCHOPHARMACOLOGY

Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress

(2016) Qian Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurological sequelae induced by alphavirus infection of the CNS are attenuated by treatment with the glutamine antagonist 6-diazo-5-oxo-l-norleucine

(2015) Michelle C. Potter et al.   JOURNAL OF NEUROVIROLOGY

Targeting glutamine metabolism rescues mice from late-stage cerebral malaria

(2015) Emile B. Gordon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia Plasticity During Health and Disease: An Immunological Perspective

(2015) Anat Shemer et al.   TRENDS IN IMMUNOLOGY

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

The role of microglia in human disease: therapeutic tool or target?

(2014) Nathalie Cartier et al.   ACTA NEUROPATHOLOGICA

Endogenous RNAs Modulate MicroRNA Sorting to Exosomes and Transfer to Acceptor Cells

(2014) Mario Leonardo Squadrito et al.   Cell Reports

Role of brain transmigrating neutrophils in depression-like behavior during systemic infection

(2013) A Aguliar-Valles et al.   MOLECULAR PSYCHIATRY

Synaptic underpinnings of altered hippocampal function in glutaminase-deficient mice during maturation

(2012) Inna Gaisler-Salomon et al.   HIPPOCAMPUS

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?

(2011) Johann Steiner et al.   Journal of Neuroinflammation

Glutaminase Dysregulation in HIV-1-Infected Human Microglia Mediates Neurotoxicity: Relevant to HIV-1-Associated Neurocognitive Disorders

(2011) Y. Huang et al.   JOURNAL OF NEUROSCIENCE

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions

(2010) Ross J. Tynan et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammation in Neurological Disorders: A Help or a Hindrance?

(2010) V. Wee Yong   NEUROSCIENTIST

Glutaminase-Deficient Mice Display Hippocampal Hypoactivity, Insensitivity to Pro-Psychotic Drugs and Potentiated Latent Inhibition: Relevance to Schizophrenia

(2009) Inna Gaisler-Salomon et al.   NEUROPSYCHOPHARMACOLOGY

Blockade of Glutamate Release from Microglia Attenuates Experimental Autoimmune Encephalomyelitis in Mice

(2009) Jin Shijie et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

(2008) Christopher J Henry et al.   Journal of Neuroinflammation

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE