From dried bear bile to molecular investigation: A systematic review of the effect of bile acids on cell apoptosis, oxidative stress and inflammation in the brain, across pre-clinical models of neurological, neurodegenerative and neuropsychiatric disorders

Paeoniflorin ameliorates neuropathic pain-induced depression-like behaviors in mice by inhibiting hippocampal neuroinflammation activated via TLR4/NF-κB pathway

(2021) Hualei Bai et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

The bile acid TUDCA and neurodegenerative disorders: An overview

(2021) Lucas Zangerolamo et al.   LIFE SCIENCES

Ursodeoxycholic Acid Inhibits Glioblastoma Progression via Endoplasmic Reticulum Stress Related Apoptosis and Synergizes with the Proteasome Inhibitor Bortezomib

(2020) Zhong Yao et al.   ACS Chemical Neuroscience

INT-777 attenuates NLRP3-ASC inflammasome-mediated neuroinflammation via TGR5/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats

(2020) Xiao Hu et al.   BRAIN BEHAVIOR AND IMMUNITY

Trial of Sodium Phenylbutyrate–Taurursodiol for Amyotrophic Lateral Sclerosis

(2020) Sabrina Paganoni et al.   NEW ENGLAND JOURNAL OF MEDICINE

A combination of three plasma bile acids as a putative biomarker for schizophrenia

(2020) Yanlin Tao et al.   ACTA NEUROPSYCHIATRICA

Ursodeoxycholic acid protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis in MPTP/MPP+-induced Parkinson’s disease

(2020) Huiping Qi et al.   NEUROSCIENCE LETTERS

The bile acid TUDCA improves glucose metabolism in streptozotocin-induced Alzheimer's disease mice model

(2020) Lucas Zangerolamo et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Comprehensive Analysis of Serum and Fecal Bile Acid Profiles and Interaction with Gut Microbiota in Primary Biliary Cholangitis

(2019) Weihua Chen et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Neurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy

(2019) Mariana Oliveira Mendes et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Phenotypic Effects of Wild-Type and Mutant SOD1 Expression in N9 Murine Microglia at Steady State, Inflammatory and Immunomodulatory Conditions

(2019) Ana Rita Vaz et al.   Frontiers in Cellular Neuroscience

Interplay between inflammation and neural plasticity: Both immune activation and suppression impair LTP and BDNF expression

(2019) Maria Teresa Golia et al.   BRAIN BEHAVIOR AND IMMUNITY

Protective effects of tauroursodeoxycholic acid on lipopolysaccharide-induced cognitive impairment and neurotoxicity in mice

(2019) Xian Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Biosynthesis, Signaling, and Neurological Functions of Bile Acids

(2019) Yoshimitsu Kiriyama et al.   Biomolecules

Tauroursodeoxycholic acid prevents ER stress-induced apoptosis and improves cerebral and vascular function in mice subjected to subarachnoid hemorrhage

(2019) Xin Chen et al.   BRAIN RESEARCH

Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders

(2019) Md. Sahab Uddin et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Mitochondrial membrane potential

(2018) Ljubava D. Zorova et al.   ANALYTICAL BIOCHEMISTRY

Neuroprotective effects of INT-777 against Aβ 1–42 -induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice

(2018) Xian Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

Tauroursodeoxycholic acid produces antidepressant-like effects in a chronic unpredictable stress model of depression via attenuation of neuroinflammation, oxido-nitrosative stress, and endoplasmic reticulum stress

(2018) Xu Lu et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Anti-inflammatory effect of Tauroursodeoxycholic acid in RAW 264.7 macrophages, Bone marrow-derived macrophages, BV2 microglial cells, and spinal cord injury

(2018) Seong Jun Kim et al.   Scientific Reports

Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease

(2018) Géraldine Gelders et al.   Journal of Immunology Research

Balancing apoptosis and autophagy for Parkinson’s disease therapy: targeting BCL-2

(2018) Jia Liu et al.   ACS Chemical Neuroscience

Bilirubin-Induced Oxidative Stress Leads to DNA Damage in the Cerebellum of Hyperbilirubinemic Neonatal Mice and Activates DNA Double-Strand Break Repair Pathways in Human Cells

(2018) Vipin Rawat et al.   Oxidative Medicine and Cellular Longevity

Tauroursodeoxycholic Acid Ameliorates Lipopolysaccharide-Induced Depression Like Behavior in Mice via the Inhibition of Neuroinflammation and Oxido-Nitrosative Stress

(2018) Li Chen et al.   PHARMACOLOGY

Synaptic Plasticity Changes: Hallmark for Neurological and Psychiatric Disorders

(2018) Giuseppina Martella et al.   NEURAL PLASTICITY

Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease

(2017) Sara Moreira et al.   EXPERIMENTAL NEUROLOGY

TUDCA: An Agonist of the Bile Acid Receptor GPBAR1/TGR5 With Anti-Inflammatory Effects in Microglial Cells

(2017) Natalia Yanguas-Casás et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Modulation of Amyloid-β Peptide-Induced Toxicity through Inhibition of JNK Nuclear Localization and Caspase-2 Activation

(2017) Ricardo J.S. Viana et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroprotective Role of Agmatine in Neurological Diseases

(2017) Weilin Xu et al.   Current Neuropharmacology

Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets

(2016) Ji-chun Zhang et al.   Current Neuropharmacology

Inflammation in Depression and the Potential for Anti-Inflammatory Treatment

(2016) Ole Kohler et al.   Current Neuropharmacology

Calcium homeostasis and low-frequency magnetic and electric field exposure: A systematic review and meta-analysis of in vitro studies

(2016) Lieke A. Golbach et al.   ENVIRONMENT INTERNATIONAL

Effects of bile acids on neurological function and disease

(2016) Matthew McMillin et al.   FASEB JOURNAL

Ursodeoxycholic Acid and S-adenosylmethionine for the Treatment of Intrahepatic Cholestasis of Pregnancy: A Meta-analysis

(2016) Yang Zhang et al.   Hepatitis Monthly

In Vitro Antimicrobial Effectiveness of Root Canal Sealers against Enterococcus faecalis: A Systematic Review

(2016) Emad AlShwaimi et al.   JOURNAL OF ENDODONTICS

Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis

(2015) A. E. Elia et al.   EUROPEAN JOURNAL OF NEUROLOGY

Oligodendrocytes and Alzheimer's disease

(2015) Zhiyou Cai et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Models of Prion Disease

(2015) Leonardo M. Cortez et al.   JOURNAL OF VIROLOGY

Deletion of mouse FXR gene disturbs multiple neurotransmitter systems and alters neurobehavior

(2015) Fei Huang et al.   Frontiers in Behavioral Neuroscience

Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study

(2015) Inês Palmela et al.   Frontiers in Neuroscience

SYRCLE’s risk of bias tool for animal studies

(2014) Carlijn R Hooijmans et al.   BMC Medical Research Methodology

Tauroursodeoxycholic acid increases neural stem cell pool and neuronal conversion by regulating mitochondria-cell cycle retrograde signaling

(2014) Joana M Xavier et al.   CELL CYCLE

Levels of Alkaline Phosphatase and Bilirubin Are Surrogate End Points of Outcomes of Patients With Primary Biliary Cirrhosis: An International Follow-up Study

(2014) Willem J. Lammers et al.   GASTROENTEROLOGY

Apoptosis-related proteins and proliferation markers in the orbitofrontal cortex in major depressive disorder

(2014) Jose J. Miguel-Hidalgo et al.   JOURNAL OF AFFECTIVE DISORDERS

Enzymatic routes for the synthesis of ursodeoxycholic acid

(2014) Thorsten Eggert et al.   JOURNAL OF BIOTECHNOLOGY

Tauroursodeoxycholic acid reduces glial cell activation in an animal model of acute neuroinflammation

(2014) Natalia Yanguas-Casás et al.   Journal of Neuroinflammation

Ursodeoxycholic Acid Ameliorates Apoptotic Cascade in the Rotenone Model of Parkinson’s Disease: Modulation of Mitochondrial Perturbations

(2014) Noha F. Abdelkader et al.   MOLECULAR NEUROBIOLOGY

Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption

(2013) Guoxiang Xie et al.   FASEB JOURNAL

Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose

(2013) J.M. Gaspar et al.   NEUROSCIENCE

Cross-Talk Between Neurons and Astrocytes in Response to Bilirubin: Adverse Secondary Impacts

(2013) Ana Sofia Falcão et al.   NEUROTOXICITY RESEARCH

AGEs Induce Cell Death via Oxidative and Endoplasmic Reticulum Stresses in Both Human SH-SY5Y Neuroblastoma Cells and Rat Cortical Neurons

(2012) Qing-Qing Yin et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice

(2012) Rita M. Ramalho et al.   NEUROBIOLOGY OF AGING

Oxidative stress and inflammation biomarkers in the blood of patients with Huntington’s disease

(2012) Fernando Sánchez-López et al.   NEUROLOGICAL RESEARCH

Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10

(2012) Sandra L. Silva et al.   NEUROPHARMACOLOGY

Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications

(2011) Marcelo G. Roma et al.   CLINICAL SCIENCE

Ursodeoxycholic acid suppresses mitochondria-dependent programmed cell death induced by sodium nitroprusside in SH-SY5Y cells

(2011) Hong Sung Chun et al.   TOXICOLOGY

Safety, Tolerability, and Cerebrospinal Fluid Penetration of Ursodeoxycholic Acid in Patients With Amyotrophic Lateral Sclerosis

(2010) Gareth J. Parry et al.   CLINICAL NEUROPHARMACOLOGY

Differentiation of various traditional Chinese medicines derived from animal bile and gallstone: Simultaneous determination of bile acids by liquid chromatography coupled with triple quadrupole mass spectrometry

(2010) Xue Qiao et al.   JOURNAL OF CHROMATOGRAPHY A

Bile acids: regulation of apoptosis by ursodeoxycholic acid

(2009) Joana D. Amaral et al.   JOURNAL OF LIPID RESEARCH

Bilirubin selectively inhibits cytochromecoxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid

(2009) Ana Rita Vaz et al.   JOURNAL OF NEUROCHEMISTRY

Bear bile: dilemma of traditional medicinal use and animal protection

(2009) Yibin Feng et al.   Journal of Ethnobiology and Ethnomedicine

Bilirubin injury to neurons: Contribution of oxidative stress and rescue by glycoursodeoxycholic acid

(2007) M BRITO   NEUROTOXICOLOGY

Tauroursodeoxycholic Acid Partially Prevents Apoptosis Induced by 3-Nitropropionic Acid

(2003) Cecilia M. P. Rodrigues et al.   JOURNAL OF NEUROCHEMISTRY