Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications

Morphologic Findings in Progressive Familial Intrahepatic Cholestasis 2 (PFIC2)

(2011) Kimberley Evason et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Cystic fibrosis-associated liver disease

(2011) Ulrike Herrmann et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

NF-κB-dependent cytokine secretion controls Fas expression on chemotherapy-induced premature senescent tumor cells

(2011) E Crescenzi et al.   ONCOGENE

Enhanced Hepatic Nrf2 Activation After Ursodeoxycholic Acid Treatment in Patients with Primary Biliary Cirrhosis

(2010) Kazuhito Kawata et al.   ANTIOXIDANTS & REDOX SIGNALING

Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of p53

(2010) Joana D. Amaral et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tauroursodeoxycholate counteracts hepatocellular lysis induced by tensioactive bile salts by preventing plasma membrane-micelle transition

(2010) Cecilia L. Basiglio et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Bile salts and cholestasis

(2010) Lucas Maillette de Buy Wenniger et al.   DIGESTIVE AND LIVER DISEASE

Ursodeoxycholic acid and chemoprevention of colorectal cancer

(2010) L. Serfaty et al.   GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE

Pathogenesis of Cholestatic Liver Disease and Therapeutic Approaches

(2010) Gideon M. Hirschfield et al.   GASTROENTEROLOGY

Biliary secretion of S-nitrosoglutathione is involved in the hypercholeresis induced by ursodeoxycholic acid in the normal rat

(2010) Carlos M. Rodríguez-Ortigosa et al.   HEPATOLOGY

Bile acid changes after high-dose ursodeoxycholic acid treatment in primary sclerosing cholangitis: Relation to disease progression

(2010) Emmanouil Sinakos et al.   HEPATOLOGY

High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: a double-blind, randomized, placebo-controlled trial

(2010) Ulrich F. H. Leuschner et al.   HEPATOLOGY

Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis

(2010) Ana Lleo et al.   HEPATOLOGY

A pilot trial of high-dose ursodeoxycholic acid in nonalcoholic steatohepatitis

(2010) Leon A. Adams et al.   Hepatology International

Endoplasmic reticulum stress in liver disease

(2010) Harmeet Malhi et al.   JOURNAL OF HEPATOLOGY

Anti-oxidants do not prevent bile acid-induced cell death in rat hepatocytes

(2010) Titia E. Woudenberg-Vrenken et al.   LIVER INTERNATIONAL

Nuclear Receptor Regulation of the Adaptive Response of Bile Acid Transporters in Cholestasis

(2010) Martin Wagner et al.   SEMINARS IN LIVER DISEASE

The Spectrum of Liver Diseases Related toABCB4Gene Mutations: Pathophysiology and Clinical Aspects

(2010) Anne Davit-Spraul et al.   SEMINARS IN LIVER DISEASE

Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1)

(2010) J. Huang et al.   XENOBIOTICA

Longitudinal Profiles of 15 Serum Bile Acids in Patients With Intrahepatic Cholestasis of Pregnancy

(2009) Rachel M Tribe et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Apoptosis and Cytokines in Non-Alcoholic Steatohepatitis

(2009) Wing-Kin Syn et al.   Clinics in Liver Disease

Endoplasmic Reticulum Stress and the Unfolded Protein Response

(2009) Ashwani Kapoor et al.   Clinics in Liver Disease

Immune-mediated liver diseases: programmed cell death ligands and circulating apoptotic markers

(2009) Andreas E Kremer et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Activation of the cholehepatic shunt as a potential therapy for primary sclerosing cholangitis

(2009) Shannon S. Glaser et al.   HEPATOLOGY

High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis

(2009) Keith D. Lindor et al.   HEPATOLOGY

Control of mitochondrial apoptosis by the Bcl-2 family

(2009) J. K. Brunelle et al.   JOURNAL OF CELL SCIENCE

Liver disease associated with canalicular transport defects: Current and future therapies

(2009) Janneke M. Stapelbroek et al.   JOURNAL OF HEPATOLOGY

Effects of ursodeoxycholic acid in combination with vitamin E on adipokines and apoptosis in patients with nonalcoholic steatohepatitis

(2009) Maria Luisa Balmer et al.   LIVER INTERNATIONAL

Bile-acid-induced cell injury and protection

(2009) Maria J Perez et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice

(2008) Kosuke Okada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Ursodeoxycholic acid induces glutathione synthesis through activation of PI3K/Akt pathway in HepG2 cells

(2008) Sakiko Arisawa et al.   BIOCHEMICAL PHARMACOLOGY

The role of membrane cholesterol in determining bile acid cytotoxicity and cytoprotection of ursodeoxycholic acid

(2008) Yong Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis

(2008) Cecilia L. Basiglio et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC -/PKA-dependent mechanism in rat liver

(2008) R Wimmer et al.   GUT

Role of mitogen-activated protein kinases in tauroursodeoxycholic acid-induced bile formation in cholestatic rat liver

(2008) Gerald Ulrich Denk et al.   HEPATOLOGY RESEARCH

Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease

(2008) K. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease

(2008) Rita M. Ramalho et al.   TRENDS IN MOLECULAR MEDICINE

Nuclear hormone receptor-dependent regulation of hepatic transporters and their role in the adaptive response in cholestasis

(2008) S. Stahl et al.   XENOBIOTICA

Tauroursodeoxycholic acid reduces bile acid-induced apoptosis by modulation of AP-1

(2007) Thomas Pusl et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ursodeoxycholic acid protects concanavalin A-induced mouse liver injury through inhibition of intrahepatic tumor necrosis factor-α and macrophage inflammatory protein-2 production

(2007) Kaoru Ishizaki et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Disturbed colocalization of multidrug resistance protein 2 and radixin in human cholestatic liver diseases

(2007) Hideyuki Kojima et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Tauroursodeoxycholic Acid Partially Prevents Apoptosis Induced by 3-Nitropropionic Acid

(2003) Cecilia M. P. Rodrigues et al.   JOURNAL OF NEUROCHEMISTRY