A CRISPR toolbox for generating intersectional genetic mouse models for functional, molecular, and anatomical circuit mapping

A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting

(2021) Ximeng Han et al.   Cell Stem Cell

Robustness of linear mixed‐effects models to violations of distributional assumptions

(2020) Holger Schielzeth et al.   Methods in Ecology and Evolution

An Intersectional Viral-Genetic Method for Fluorescent Tracing of Axon Collaterals Reveals Details of Noradrenergic Locus Coeruleus Structure

(2020) Nicholas W. Plummer et al.   eNeuro

Temporal evolution of cortical ensembles promoting remote memory retrieval

(2019) Laura A. DeNardo et al.   NATURE NEUROSCIENCE

Follicle-stimulating hormone and luteinizing hormone increase Ca2+ in the granulosa cells of mouse ovarian follicles†

(2019) Jeremy R Egbert et al.   BIOLOGY OF REPRODUCTION

Off-Target Effects of Clozapine-N-Oxide on the Chemosensory Reflex Are Masked by High Stress Levels

(2019) Vena K. Martinez et al.   Frontiers in Physiology

Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas

(2019) Federico Scala et al.   Nature Communications

Selective Brain Distribution and Distinctive Synaptic Architecture of Dual Glutamatergic-GABAergic Neurons

(2018) David H. Root et al.   Cell Reports

Genetic identification of a population of noradrenergic neurons implicated in attenuation of stress-related responses

(2018) Yu-Wei Chen et al.   MOLECULAR PSYCHIATRY

Activity of Tachykinin1 -Expressing Pet1 Raphe Neurons Modulates the Respiratory Chemoreflex

(2017) Morgan L. Hennessy et al.   JOURNAL OF NEUROSCIENCE

AAV-Mediated Anterograde Transsynaptic Tagging: Mapping Corticocollicular Input-Defined Neural Pathways for Defense Behaviors

(2017) Brian Zingg et al.   NEURON

Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes

(2016) Van Trung Chu et al.   BMC BIOTECHNOLOGY

In vitro characterization of noradrenergic modulation of chemosensitive neurons in the retrotrapezoid nucleus

(2016) Fu-Shan Kuo et al.   JOURNAL OF NEUROPHYSIOLOGY

A photoactivatable Cre–loxP recombination system for optogenetic genome engineering

(2016) Fuun Kawano et al.   Nature Chemical Biology

Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex

(2016) Miao He et al.   NEURON

A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons

(2016) D. Gowanlock R. Tervo et al.   NEURON

ssODN-mediated knock-in with CRISPR-Cas for large genomic regions in zygotes

(2016) Kazuto Yoshimi et al.   Nature Communications

Impaired Recall of Positional Memory following Chemogenetic Disruption of Place Field Stability

(2016) Rong Zhao et al.   Cell Reports

Identification of Serotonergic Neuronal Modules that Affect Aggressive Behavior

(2016) Vera Niederkofler et al.   Cell Reports

Generation of Two Noradrenergic-Specific Dopamine-Beta-Hydroxylase-FLPo Knock-In Mice Using CRISPR/Cas9-Mediated Targeting in Embryonic Stem Cells

(2016) Jenny J. Sun et al.   PLoS One

Highly efficient CRISPR/HDR-mediated knock-in for mouse embryonic stem cells and zygotes

(2015) Bangmei Wang et al.   BIOTECHNIQUES

Isoflurane abolishes spontaneous firing of serotonin neurons and masks their pH/CO2 chemosensitivity

(2015) Cory A. Massey et al.   JOURNAL OF NEUROPHYSIOLOGY

Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes

(2015) János Fuzik et al.   NATURE BIOTECHNOLOGY

Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq

(2015) Cathryn R Cadwell et al.   NATURE BIOTECHNOLOGY

Cell type–specific manipulation with GFP-dependent Cre recombinase

(2015) Jonathan C Y Tang et al.   NATURE NEUROSCIENCE

Intersectional Illumination of Neural Circuit Function

(2015) William E. Allen et al.   NEURON

Neural Control of Breathing and CO2 Homeostasis

(2015) Patrice G. Guyenet et al.   NEURON

Transgenic Mice for Intersectional Targeting of Neural Sensors and Effectors with High Specificity and Performance

(2015) Linda Madisen et al.   NEURON

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior

(2015) Eyal Vardy et al.   NEURON

Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles

(2015) Leia C. Shuhaibar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Principles of connectivity among morphologically defined cell types in adult neocortex

(2015) X. Jiang et al.   SCIENCE

The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO2

(2015) Pierre-Louis Ruffault et al.   eLife

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

Identification of Spinal Circuits Transmitting and Gating Mechanical Pain

(2014) Bo Duan et al.   CELL

CRISPR-Cas systems for editing, regulating and targeting genomes

(2014) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

Optimized ratiometric calcium sensors for functional in vivo imaging of neurons and T lymphocytes

(2014) Thomas Thestrup et al.   NATURE METHODS

Noninvasive optical inhibition with a red-shifted microbial rhodopsin

(2014) Amy S Chuong et al.   NATURE NEUROSCIENCE

Cell type–specific mRNA purification by translating ribosome affinity purification (TRAP)

(2014) Myriam Heiman et al.   Nature Protocols

GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment

(2014) S. J. Shabel et al.   SCIENCE

Functional and Developmental Identification of a Molecular Subtype of Brain Serotonergic Neuron Specialized to Regulate Breathing Dynamics

(2014) Rachael D. Brust et al.   Cell Reports

APhox2b::FLPotransgenic mouse line suitable for intersectional genetics

(2013) Marie-Rose Hirsch et al.   GENESIS

An optimized fluorescent probe for visualizing glutamate neurotransmission

(2013) Jonathan S Marvin et al.   NATURE METHODS

Developmental origins of central norepinephrine neuron diversity

(2013) Sabrina D Robertson et al.   NATURE NEUROSCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Egr2-neurons control the adult respiratory response to hypercapnia

(2012) Russell S. Ray et al.   BRAIN RESEARCH

A dominant negative Cx43 mutant differentially affects tumorigenic and invasive properties in human metastatic melanoma cells

(2012) Shoshanna N. Zucker et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Imaging neural circuit dynamics with a voltage-sensitive fluorescent protein

(2012) Walther Akemann et al.   JOURNAL OF NEUROPHYSIOLOGY

Conditional expression of the TVA receptor allows clonal analysis of descendents from Cre-expressing progenitor cells

(2011) Kevin T. Beier et al.   DEVELOPMENTAL BIOLOGY

Projections and interconnections of genetically defined serotonin neurons in mice

(2011) Sun Jung Bang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors

(2011) K. T. Beier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical and Genetic Engineering of Selective Ion Channel-Ligand Interactions

(2011) C. J. Magnus et al.   SCIENCE

Impaired Respiratory and Body Temperature Control Upon Acute Serotonergic Neuron Inhibition

(2011) R. S. Ray et al.   SCIENCE

Genetically Increased Cell-Intrinsic Excitability Enhances Neuronal Integration into Adult Brain Circuits

(2010) Chia-Wei Lin et al.   NEURON

Visualizing the Distribution of Synapses from Individual Neurons in the Mouse Brain

(2010) Ling Li et al.   PLoS One

The locus coeruleus and central chemosensitivity

(2010) Luciane H. Gargaglioni et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Cell-selective metabolic labeling of proteins

(2009) John T Ngo et al.   Nature Chemical Biology

Linking Genetically Defined Neurons to Behavior through a Broadly Applicable Silencing Allele

(2009) Jun Chul Kim et al.   NEURON

Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

(2009) Georgia M. Alexander et al.   NEURON

A chemical-genetic approach to study G protein regulation of β cell function in vivo

(2009) Jean-Marc Guettier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types

(2008) Joseph P. Doyle et al.   CELL

Engineering GPCR signaling pathways with RASSLs

(2008) Bruce R Conklin et al.   NATURE METHODS

Redefining the serotonergic system by genetic lineage

(2008) Patricia Jensen et al.   NATURE NEUROSCIENCE

A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons

(2008) V. Dubreuil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noradrenergic modulation of the respiratory neural network

(2008) Jean-Charles Viemari   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY