Review
Urology & Nephrology
Thomas A. Masterson, Darren Turner, Duyen Vo, Ruben Blachman-Braun, Jordan C. Best, Gerwin Westfield, Nathan Bryson, Ranjith Ramasamy
Summary: The study found that short-acting testosterone preparations have less suppression on FSH and LH compared to longer-acting formulations, indicating potential differences in the impact on semen parameters and fertility. Further clinical trial data is needed to confirm these findings.
SEXUAL MEDICINE REVIEWS
(2021)
Article
Endocrinology & Metabolism
Teresa Zarinan, Julio Mayorga, Eduardo Jardon-Valadez, Ruben Gutierrez-Sagal, Jose Luis Maravillas-Montero, Nancy R. Mejia-Dominguez, Ivan Martinez-Luis, Omar G. Yacini-Torres, Ma del-Carmen Cravioto, Eric Reiter, Alfredo Ulloa-Aguirre
Summary: A novel missense mutation (I423T) in the FSHR second transmembrane domain was identified in a woman with primary ovarian failure, leading to impaired receptor expression and signaling. Meanwhile, the D408Y mutation severely affected membrane expression and signal transduction. Molecular dynamics simulations showed important disruptions in both mutant FSHRs, explaining the differences in expression levels, signaling, and phenotypic expression between I423T and D408Y mutant FSHRs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Agriculture, Dairy & Animal Science
Victor E. Gomez-Leon, Adam D. Beard, O. J. Ginther, Milo C. Wiltbank
Summary: This study aimed to investigate the impact of low-dose hCG on multiple ovulations in lactating dairy cows. The results showed that increased hCG led to larger follicle sizes and higher FSH concentrations, resulting in an increased frequency of double ovulation.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yuichi Shima, Kanako Miyabayashi, Takami Mori, Koji Ono, Mizuki Kajimoto, Hae Lim Cho, Hitomi Tsuchida, Yoshihisa Uenoyama, Hiroko Tsukamura, Kentaro Suzuki, Man Ho Choi, Kazunori Toida
Summary: This study discovered that deletion of the pituitary enhancer located in the 6th intron of the Nr5a1 gene in mice leads to the disappearance of NR5A1 in the pituitary gland and severely affects the development of reproductive organs. Transcriptomic analysis further identified genes that are specifically dependent on NR5A1 expression in pituitary gonadotropes, which play important roles in reproductive organ development through regulation of pituitary gonadotrope functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Chao Xu, Zhao He, Yongfeng Song, Shanshan Shao, Guang Yang, Jiajun Zhao
Summary: It has been traditionally believed that pituitary hormones act on their cognate receptors in classical target glands to carry out their various functions. However, recent studies have revealed that multiple types of pituitary hormone receptors are widely expressed in non-classical target organs. This article summarizes the additional biological functions of pituitary hormones (thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, adrenocorticotrophic hormone, and prolactin) when they act on non-classical organs, defining them as part of an atypical pituitary hormone-target tissue axis. This novel concept provides insight into the mechanisms behind metabolic diseases and offers potential novel therapeutic targets.
FRONTIERS OF MEDICINE
(2023)
Article
Cell Biology
Hirofumi Ohga, Kosuke Ito, Kohei Kakino, Hiroaki Mon, Takahiro Kusakabe, Jae Man Lee, Michiya Matsuyama
Summary: The study demonstrated that leptin directly regulates the synthesis and secretion of gonadotropins, playing an important role in the onset of puberty in teleost fish.
Article
Biology
Vitaly Ryu, Anisa Gumerova, Funda Korkmaz, Seong Su Kang, Pavel Katsel, Sari Miyashita, Hasni Kannangara, Liam Cullen, Pokman Chan, TanChun Kuo, Ashley Padilla, Farhath Sultana, Soleil A. Wizman, Natan Kramskiy, Samir Zaidi, Se-Min Kim, Maria New, Clifford J. Rosen, Ki A. Goosens, Tal Frolinger, Vahram Haroutunian, Keqiang Ye, Daria Lizneva, Terry F. Davies, Tony Yuen, Mone Zaidi
Summary: There is increasing evidence that anterior pituitary hormones have multiple functions in regulating somatic tissues and brain receptors. A comprehensive neuroanatomical atlas on the expression of TSHR, LHCGR, and FSHR has been created using single-transcript detection technology. This atlas provides a vital resource for studying the impact of glycoprotein hormone receptors on somatic function and may uncover new pathways for human disease.
Article
Environmental Sciences
Anissa Lambertino, Victoria Persky, Sally Freels, Henry Anderson, Terry Unterman, Saria Awadalla, Mary Turyk
Summary: The study aimed to evaluate the associations of POPs with hormone levels in postmenopausal women, finding that exposure to dioxin-like POPs was negatively associated with LH, but not with FSH. These negative associations were influenced by potential effect modifiers such as obesity and inflammation.
Article
Reproductive Biology
Hirofumi Ohga, Michiya Matsuyama
Summary: The chub mackerel LPXRFamide gene produces three mature peptides and does not have the ability to suppress gonadotropin secretion but may promote gonadotropin secretion.
BIOLOGY OF REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Amanda de Moraes Narcizo, Tiago Gabriel Correia, Adalto Bianchini, Mario Gustavo Mayer, Ricardo Andrade Zampieri, Lucile Maria Floeter-Winter, Renata Guimaraes Moreira
Summary: This study revealed that aluminum and acidic pH can influence the bioconcentration of aluminum in Oreochromis niloticus females, with aluminum potentially acting as an endocrine disruptor directly affecting ovarian steroidogenesis.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Yukinori Kazeto, Risa Ito, Toshiomi Tanaka, Hiroshi Suzuki, Yuichi Ozaki, Koichi Okuzawa, Koichiro Gen
Summary: This study established stable CHO-DG44 cell lines expressing recombinant Japanese eel Fsh and Lh, and found that Fsh-hCTP induced the ovarian development of eels within 8 weeks, while Lh-hCTP needed 4 weeks; Fsh-hCTP also significantly increased the number of mature ovarian follicles, while Lh-hCTP had a smaller impact on the ovaries.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pediatrics
Dan Xu, Xueying Zhou, Junfei Wang, Xi Cao, Tao Liu
Summary: This meta-analysis compares the diagnostic value of urinary gonadotropins and the GnRH stimulation test for central precocious puberty (CPP). The results suggest that both urinary luteinizing hormone (ULH) level and ULH:UFSH ratio are effective approaches for CPP diagnosis.
Article
Reproductive Biology
Corie M. Owen, Laurinda A. Jaffe
Summary: The present study reveals that LH stimulation induces granulosa cell ingression in the mural granulosa layer, leading to changes in the follicular structure. This cellular ingression begins shortly after the LH surge and continues until ovulation, with an increase in the proportion of LH receptor-expressing cells in the inner half of the mural granulosa layer. Additionally, the study also observes changes in cell shape and follicular structure during this process.
BIOLOGY OF REPRODUCTION
(2023)
Article
Reproductive Biology
Wei Yang, Ning Zhang, Yangsheng Wu, Lanxin Zhang, Lihong Zhang, Weimin Zhang
Summary: The study found that isotocin may regulate the synthesis and release of Lh in female ricefield eels through the Istr2 receptor, correlating with ovarian vitellogenesis. Additionally, the involvement of the IP3/Ca2+ pathway in Lh release was revealed in dispersed pituitary cells.
BIOLOGY OF REPRODUCTION
(2021)
Article
Andrology
Yongjie Liu, Guoping Wang, Fan Zhang, Liang Dai
Summary: This study investigated the serum levels of reproductive hormones in men with azoospermia and explored the correlation between abnormal reproductive hormones and testicular biopsy and seminiferous extraction results. The results showed that FSH and LH levels were associated with azoospermia and could potentially predict the acquisition of spermatozoa through testicular biopsy in a clinical setting.
Article
Neurosciences
Dahdjim B. Betolngar, Elia Mota, Arne Fabritius, Jacob Nielsen, Charlotte Hougaard, Claus T. Christoffersen, Jun Yang, Jan Kehler, Oliver Griesbeck, Liliana R. Castro, Pierre Vincent
Article
Veterinary Sciences
L. Fernando Campos-Chillon, Corie M. Owen, Joy L. Altermatt
JOURNAL OF EQUINE VETERINARY SCIENCE
(2019)
Article
Endocrinology & Metabolism
Valentina Baena, Corie M. Owen, Tracy F. Uliasz, Katie M. Lowther, Siu-Pok Yee, Mark Terasaki, Jeremy R. Egbert, Laurinda A. Jaffe
Article
Endocrinology & Metabolism
Rachel G. Felton, Corie M. Owen, Jennifer M. Cossaboon, Cynthia C. Steiner, Christopher W. Tubbs
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2020)
Article
Neurosciences
Shenbin Liu, Zhi-Fu Wang, Yang-Shuai Su, Russell S. Ray, Xiang-Hong Jing, Yan-Qing Wang, Qiufu Ma
Letter
Reproductive Biology
Corie M. Owen, Xiang Zhou, Daniel J. Bernard, Laurinda A. Jaffe
BIOLOGY OF REPRODUCTION
(2021)
Article
Agriculture, Dairy & Animal Science
Corie M. Owen, Melissa A. Johnson, Katherine A. Rhodes-Long, Diana J. Gumber, Moises Barcelo-Fimbres, Joy L. Altermatt, Lino Fernando Campos-Chillon
Summary: Using a combination of metabolic regulators in culture media can improve the development and cryotolerance of in vitro produced embryos. The use of Synthetic oviductal fluid for Conventional Freezing 1 (SCF1) culture media and an optimized slow freezing technique results in improved pregnancy rates for frozen IVP embryos compared to embryos cultured in a synthetic oviductal fluid media.
JOURNAL OF ANIMAL SCIENCE
(2022)
Review
Neurosciences
Ariel A. Valiente-Gabioud, Arne Fabritius, Oliver Griesbeck
Summary: Calcium in interstitial fluids is crucial for cellular entry and is actively sensed by receptors. Current methods for studying local calcium handling in interstitial spaces are reviewed, and the potential of new genetically encoded calcium indicators is highlighted.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Neurosciences
Savannah Lusk, Christopher S. Ward, Andersen Chang, Avery Twitchell-Heyne, Shaun Fattig, Genevera Allen, Joanna L. Jankowsky, Russell S. Ray
Summary: Comprehensive and accurate analysis of respiratory and metabolic data is crucial for studying diseases, and the lack of tools for high-throughput analysis is a challenge. This study introduces a new open-source pipeline called Breathe Easy, which improves the efficiency of respiratory data analysis and generates effective results and publication-worthy statistical analysis graphs. The validity of this pipeline is confirmed through a long-term study on an Alzheimer's disease mouse model.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Health Care Sciences & Services
Isaac D. Raplee, Alexei Evsikov, Caralina Marin de Evsikova
JOURNAL OF PERSONALIZED MEDICINE
(2019)
Article
Health Care Sciences & Services
Caralina Marin de Evsikova, Isaac D. Raplee, John Lockhart, Gilberto Jaimes, Alexei Evsikov
JOURNAL OF PERSONALIZED MEDICINE
(2019)