Journal
CELL REPORTS
Volume 16, Issue 3, Pages 793-804Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2016.06.032
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Funding
- NIH Director's New Innovator Award [DP2 OD001734, R21 MH101583, T32 AG000183]
- Bright-Focus Foundation postdoctoral fellowship [A2015016F]
- Baylor College of Medicine
- Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research
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The neural network of the temporal lobe is thought to provide a cognitive map of our surroundings. Functional analysis of this network has been hampered by coarse tools that often result in collateral damage to other circuits. We developed a chemogenetic system to temporally control electrical input into the hippocampus. When entorhinal input to the perforant path was acutely silenced, hippocampal firing patterns became destabilized and underwent extensive remapping. We also found that spatial memory acquired prior to neural silencing was impaired by loss of input through the perforant path. Together, our experiments show that manipulation of entorhinal activity destabilizes spatial coding and disrupts spatial memory. Moreover, we introduce a chemogenetic model for non-invasive neuronal silencing that offers multiple advantages over existing strategies in this setting.
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