Article
Respiratory System
Yewon Chung, Frances L. Garden, Guy B. Marks, Hima Vedam
Summary: The study aimed to determine the causes and their effect on in-hospital mortality of hypercapnic respiratory failure (HRF). The results showed that HRF is associated with a range of potentially causative conditions, and some of them significantly impact hospital survival. Therefore, systematic evaluation of HRF patients may help to detect treatable comorbidities.
Article
Medicine, General & Internal
Mark Juniper
Summary: The National Early Warning Score (NEWS) is widely used in clinical practice in the UK to improve patient safety. In 2017, the original score was adapted to include a separate scoring system for oxygen saturation in patients with respiratory diseases. This article reviews the evidence for the effectiveness of the improved score.
Article
Cell Biology
Eleanor J. Tyler, Ana Gutierrez del Arroyo, Bethany K. Hughes, Ryan Wallis, James C. Garbe, Martha R. Stampfer, Jim Koh, Robert Lowe, Michael P. Philpott, Cleo L. Bishop
Summary: EGR2 is identified as a novel regulator of senescence, with up-regulated expression during senescence. It activates the ARF and p16 promoters and directly binds to them. Loss of EGR2 results in down-regulation of p16 levels and an increase in the population of p16- p21- 'reversed' cells.
Article
Respiratory System
Yewon Chung, Frances L. Garden, Guy B. Marks, Hima Vedam
Summary: The study found that chronic obstructive pulmonary disease (COPD), congestive cardiac failure, and self-reported use of opioid medications are important causes of hypercapnic respiratory failure (HRF) among adults over 40 years old, while obstructive sleep apnea is not a major cause.
BMC PULMONARY MEDICINE
(2023)
Article
Critical Care Medicine
Kazuma Nagata, Takeo Horie, Naohiko Chohnabayashi, Torahiko Jinta, Ryosuke Tsugitomi, Akira Shiraki, Fumiaki Tokioka, Toru Kadowaki, Akira Watanabe, Motonari Fukui, Takamasa Kitajima, Susumu Sato, Toru Tsuda, Nobuhito Kishimoto, Hideo Kita, Yoshihiro Mori, Masayuki Nakayama, Kenichi Takahashi, Tomomasa Tsuboi, Makoto Yoshida, Osamu Hataji, Satoshi Fuke, Michiko Kagajo, Hiroki Nishine, Hiroyasu Kobayashi, Hiroyuki Nakamura, Miyuki Okuda, Sayaka Tachibana, Shohei Takata, Hisayuki Osoreda, Kenichi Minami, Takashi Nishimura, Tadashi Ishida, Jiro Terada, Naoko Takeuchi, Yasuo Kohashi, Hiromasa Inoue, Yoko Nakagawa, Takashi Kikuchi, Keisuke Tomii
Summary: The study found that long-term use of high-flow nasal cannula can reduce the number of exacerbations in patients with chronic obstructive pulmonary disease, improving physiological parameters and quality of life.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Respiratory System
Neeraj M. Shah, Joerg Steier, Nicholas Hart, Georgios Kaltsakas
Summary: Chronic respiratory disease can worsen sleep quality, and non-invasive ventilation is a complex intervention used for improving sleep-disordered breathing and nocturnal hypoventilation. However, the impact on sleep quality depends on measurement tools and patient population.
Article
Health Care Sciences & Services
Priyadarshini Kachroo, Joanne E. Sordillo, Sharon M. Lutz, Scott T. Weiss, Rachel S. Kelly, Michael J. McGeachie, Ann Chen Wu, Jessica A. Lasky-Su
Summary: Metabolomic profiles associated with asthma exacerbations during inhaled corticosteroid treatment were analyzed in this study, revealing potential biomarkers of treatment response variability. Sex differences were observed in the levels of fatty acid metabolites during exacerbations, while interactions between age and metabolites on exacerbation were also detected. These findings suggest that plasma metabolites may play a role in elucidating metabolic pathways underlying variability in asthma treatment responses.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Xiang Geng, YangYang Sun, JinJin Fu, Liang Cao, Yuan Li
Summary: The study found that miR-17-5p plays a crucial role in thyroid cancer by modulating EGR2, its inhibition can suppress cell proliferation, migration, and invasion, while also inhibiting tumor formation in vivo. Additionally, miR-17-5p has a negative regulatory effect on EGR2, with EGR2 overexpression inhibiting thyroid carcinoma development both in vitro and in vivo. EGR2 knockdown significantly decreased the anti-cancer effect of miR-17-5p inhibition.
Article
Immunology
[Anonymous]
Summary: In this study, the transcription factor EGR2 is identified as a crucial factor for T(H)17 cell pathogenicity. It regulates T(H)17 cell migration, the expression of pathogenicity-related genes, and facilitates the recruitment of immune cells in the central nervous system.
Article
Medicine, General & Internal
Alexandru Tudor Steriade, Mihai Gologanu, Roxana Silvia Bumbacea, Stefan Nicolae Bogdan, Dragos Bumbacea
Summary: Esophageal pressure (Pes) measurements can optimize ventilator parameters in patients with acute respiratory failure. This study evaluated the safety and accuracy of a Pes measuring protocol in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) receiving noninvasive ventilation (NIV). It was found that under NIV, the reduction of increment Pes is most significant within the first 24 hours of admission.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Isato Fukushi, Shigefumi Yokota, Kotaro Takeda, Jiro Terada, Akira Umeda, Masashi Yoshizawa, Yosuke Kono, Yohei Hasebe, Hiroshi Onimaru, Mieczyslaw Pokorski, Yasumasa Okada
Summary: This study investigates the effects of the insomnia drug Suvorexant on the respiratory system and shows the involvement of orexin in respiratory control. Suvorexant suppresses the augmented ventilation in hypercapnia, but does not affect ventilation.
Article
Respiratory System
A. Ozsancak Ugurlu, B. Ergan
Summary: Noninvasive ventilation (NIV) is increasingly used for acute hypercapnic respiratory failure (AHRF), but there is a lack of studies comparing different strategies for weaning patients off NIV. No method has been established as superior in terms of success rate, duration of NIV, mortality, length of stay, or ICU outcomes. Patient factors can help predict weaning outcome and guide individualized approaches. This paper provides strategies for weaning AHRF patients off NIV based on experience and current evidence.
Article
Clinical Neurology
Rup K. Sainju, Deidre N. Dragon, Harold B. Winnike, Patrick Ten Eyck, Mark A. Granner, Brian K. Gehlbach, George B. Richerson
Summary: The study investigated whether chronic electrical stimulation of the vagus nerve in patients with epilepsy alters central CO2 chemoreception. Results showed that using VNS was associated with an attenuated HCVR slope, while high BMI was associated with a high HCVR slope.
Article
Physiology
Giovanni Tagliabue, Michael Ji, Jenny V. Suneby Jagers, Dan J. Zuege, Teresa M. Kieser, Paul A. Easton
Summary: This study aims to investigate the activation and length changes of transversus abdominis during normal breathing and hypercapnia. The results showed that transversus abdominis is recruited during normal breathing and its recruitment increases during hypercapnia. Furthermore, the baseline end-inspiratory length of transversus abdominis decreases progressively during hypercapnia. Therefore, the clinical monitoring of abdominal wall motion during respiratory failure may be confounded by the action of transversus abdominis.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2022)
Review
Medicine, General & Internal
Bulin Du, Shu Wang, Yan Cui, Guanghui Liu, Xuena Li, Yaming Li
Summary: Meta-analysis results revealed that F-18-FDG PET/CT had low pooled sensitivity and specificity, indicating caution should be taken when using it to predict EGFR mutations in patients with NSCLC.
Article
Neurosciences
Benjamin W. Okaty, Morgan E. Freret, Benjamin D. Rood, Rachael D. Brust, Morgan L. Hennessy, Danielle debairos, Jun Chul Kim, Melloni N. Cook, Susan M. Dymecki
Article
Neurosciences
Karlene T. Barrett, Ryan T. Dosumu-Johnson, J. Andrew Daubenspeck, Rachael D. Brust, Vasileios Kreouzis, Jun Chul Kim, Aihua Li, Susan M. Dymecki, Eugene E. Nattie
JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Morgan L. Hennessy, Andrea E. Corcoran, Rachael D. Brust, YoonJeung Chang, Eugene E. Nattie, Susan M. Dymecki
JOURNAL OF NEUROSCIENCE
(2017)
Article
Cardiac & Cardiovascular Systems
Kurt A. Engleka, Lauren J. Manderfield, Rachael D. Brust, Li Li, Ashley Cohen, Susan M. Dymecki, Jonathan A. Epstein
CIRCULATION RESEARCH
(2012)
Meeting Abstract
Developmental Biology
Susan Dymecki, Russell Ray, Rachael Brust, Patricia Jensen, Jun Chul Kim, Andrea Corcoran, George Richerson, Eugene Nattie
DEVELOPMENTAL BIOLOGY
(2011)
Article
Multidisciplinary Sciences
Russell S. Ray, Andrea E. Corcoran, Rachael D. Brust, Jun Chul Kim, George B. Richerson, Eugene Nattie, Susan M. Dymecki
Editorial Material
Multidisciplinary Sciences
Susan M. Dymecki, Russell R. Ray, Rachael D. Brust, Andrea E. Corcoran, Jun Chul Kim, George B. Richerson, Eugene Nattie
Article
Cell Biology
Rachael D. Brust, Andrea E. Corcoran, George B. Richerson, Eugene Nattie, Susan M. Dymecki
Article
Biochemistry & Molecular Biology
Sara L. Prescott, Benjamin D. Umans, Erika K. Williams, Rachael D. Brust, Stephen D. Liberles
Article
Biochemistry & Molecular Biology
Chiemezie C. Amadi, Rachael D. Brust, Matthew R. Skerritt, Donald L. Campbell
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.