Raman based chemometric model development for glycation and glycosylation real time monitoring in a manufacturing scale CHO cell bioreactor process

Analysis of chemometric models applied to Raman spectroscopy for monitoring key metabolites of cell culture

(2020) Carl Rafferty et al.   BIOTECHNOLOGY PROGRESS

Raman spectroscopy as a method to replace off‐line pH during mammalian cell culture processes

(2019) Carl Rafferty et al.   BIOTECHNOLOGY AND BIOENGINEERING

Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells

(2019) Valentine Chevallier et al.   BIOTECHNOLOGY AND BIOENGINEERING

Real-time monitoring of antibody glycosylation site occupancy by in situ Raman spectroscopy during bioreactor CHO cell cultures

(2018) Meng-Yao Li et al.   BIOTECHNOLOGY PROGRESS

Glucose monitoring and adaptive feeding of mammalian cell culture in the presence of strong autofluorescence by near infrared Raman spectroscopy

(2018) Thomas E. Matthews et al.   BIOTECHNOLOGY PROGRESS

Glycation of antibodies: Modification, methods and potential effects on biological functions

(2017) Bingchuan Wei et al.   mAbs

Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing

(2016) Karen A. Esmonde-White et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

High-Throughput, Automated Protein A Purification Platform with Multiattribute LC–MS Analysis for Advanced Cell Culture Process Monitoring

(2016) Jia Dong et al.   ANALYTICAL CHEMISTRY

Glycosylation of monoclonal antibody products: Current status and future prospects

(2016) Jyoti Batra et al.   BIOTECHNOLOGY PROGRESS

In-line and real-time prediction of recombinant antibody titer by in situ Raman spectroscopy

(2015) Silvère André et al.   ANALYTICA CHIMICA ACTA

Mid-infrared spectroscopy-based analysis of mammalian cell culture Parameters

(2015) Florian Capito et al.   BIOTECHNOLOGY PROGRESS

Understanding Pharmaceutical Quality by Design

(2014) Lawrence X. Yu et al.   AAPS Journal

Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture

(2013) Neil Templeton et al.   BIOTECHNOLOGY AND BIOENGINEERING

Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation

(2012) Darius Ghaderi et al.   Biotechnology & Genetic Engineering Reviews

Monitoring the Glycosylation Status of Proteins Using Raman Spectroscopy

(2011) Victoria L. Brewster et al.   ANALYTICAL CHEMISTRY

Glycosylation profiles of therapeutic antibody pharmaceuticals

(2011) Christoph Wacker et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe

(2010) Nicholas R. Abu-Absi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Stability of Protein Pharmaceuticals: An Update

(2010) Mark Cornell Manning et al.   PHARMACEUTICAL RESEARCH

Quality by design for biopharmaceuticals

(2009) Anurag S Rathore et al.   NATURE BIOTECHNOLOGY

A Perspective on the Maillard Reaction and the Analysis of Protein Glycation by Mass Spectrometry: Probing the Pathogenesis of Chronic Disease

(2008) Qibin Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Pharmaceutical Quality by Design: Product and Process Development, Understanding, and Control

(2008) Lawrence X. Yu   PHARMACEUTICAL RESEARCH