Restoration of DNA repair mitigates genome instability and increases productivity of Chinese hamster ovary cells
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Title
Restoration of DNA repair mitigates genome instability and increases productivity of Chinese hamster ovary cells
Authors
Keywords
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Journal
BIOTECHNOLOGY AND BIOENGINEERING
Volume 119, Issue 3, Pages 963-982
Publisher
Wiley
Online
2021-12-25
DOI
10.1002/bit.28016
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- (2019) Hussain Dahodwala et al. CURRENT OPINION IN BIOTECHNOLOGY
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- (2018) Arpan A. Bandyopadhyay et al. BIOTECHNOLOGY AND BIOENGINEERING
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- CRISPR/Cas9-mediated genome engineering of CHO cell factories: Application and perspectives
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- CRISPR/Cas9-mediated genome engineering of CHO cell factories: Application and perspectives
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- Rapid construction of transgene-amplified CHO cell lines by cell cycle checkpoint engineering
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- Unstable expression of recombinant antibody during long-term culture of CHO cells is accompanied by histone H3 hypoacetylation
- (2013) Verenice Paredes et al. BIOTECHNOLOGY LETTERS
- The emerging CHO systems biology era: harnessing the ‘omics revolution for biotechnology
- (2013) Helene Faustrup Kildegaard et al. CURRENT OPINION IN BIOTECHNOLOGY
- Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome
- (2013) Nathan E Lewis et al. NATURE BIOTECHNOLOGY
- Effects of high passage cultivation on CHO cells: a global analysis
- (2012) T. F. Beckmann et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
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- (2012) Laura A Bailey et al. BIOTECHNOLOGY AND BIOENGINEERING
- A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff
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- (2012) Yongwook Choi et al. PLoS One
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- (2012) Pablo Cingolani et al. Frontiers in Genetics
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- (2011) Xun Xu et al. NATURE BIOTECHNOLOGY
- The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
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