Unstable expression of recombinant antibody during long-term culture of CHO cells is accompanied by histone H3 hypoacetylation

Title
Unstable expression of recombinant antibody during long-term culture of CHO cells is accompanied by histone H3 hypoacetylation
Authors
Keywords
CHO cell, Histone acetylation, Long-term culture, Production instability, Recombinant protein expression, Transgene silencing
Journal
BIOTECHNOLOGY LETTERS
Volume 35, Issue 7, Pages 987-993
Publisher
Springer Nature
Online
2013-03-06
DOI
10.1007/s10529-013-1168-8

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