Review
Biochemistry & Molecular Biology
Qiong Wu, Anders E. Berglund, Arnold B. Etame
Summary: Glioblastoma is highly resistant to standard therapies and the durability of response to the best chemotherapy agent, Temozolomide, is often short-lived due to tumor resistance. The need for therapies that can provide synergy to chemoradiation is urgent, as adaptive resistance evolution in GBM is facilitated through treatment-induced epigenetic modifications. Understanding and targeting these epigenetic modifications associated with GBM resistance is a top priority.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Jun-Li Wang, Dong-Wei Di, Pan Luo, Li Zhang, Xiao-Feng Li, Guang-Qin Guo, Lei Wu
Summary: This review focuses on the molecular mechanisms through which epigenetic modifications regulate auxin biosynthesis, demonstrating that complex signaling pathways affect gene expression and subsequently protein production.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Oncology
Francisco Gimeno-Valiente, Gerardo Lopez-Rodas, Josefa Castillo, Luis Franco
Summary: This review focuses on the interconnections between epigenetics and alternative splicing in the development of cancer. It discusses the mechanisms involved in these interconnections and the potential diagnostic and therapeutic tools that can be derived from them. The reversible nature of epigenetic alterations and the possibility of correcting aberrant alternative splicing offer promising therapeutic possibilities for cancer treatment.
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Review
Environmental Sciences
Arijit Chakraborty, Soma Ghosh, Bratisha Biswas, Sreemanta Pramanik, Jerome Nriagu, Subhamoy Bhowmick
Summary: Arsenic exposure can cause harmful epigenetic alterations, leading to various health complications. This review summarizes the mechanisms underlying arsenic-induced epigenetic changes and proposes therapeutic strategies to alleviate the global burden of arsenic poisoning.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Dermatology
Chang Zeng, Lam C. Tsoi, Johann E. Gudjonsson
Summary: The incidence of psoriasis is increasing over time, with recent studies pointing towards the importance of epigenetic modifications in its pathogenesis. Aberrant epigenetic patterns, including changes in DNA methylation, histone modifications and non-coding RNA expression, are observed in psoriatic skin. Reversing these epigenetic mechanisms has shown promise in improving psoriatic phenotypes, making epigenetic therapy a potential avenue for treating psoriasis.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Plant Sciences
Muthusamy Ramakrishnan, Mingbing Zhou, Stanislaus Antony Ceasar, Doulathunnisa Jaffar Ali, Theivanayagam Maharajan, Kunnummal Kurungara Vinod, Anket Sharma, Zishan Ahmad, Qiang Wei
Summary: Somatic embryogenesis is a complex process regulated by genetic and epigenetic factors, including DNA and histone modifications, as well as miRNA regulation. These regulations influence the transition of somatic cells and the development of embryos, with the potential for somatic cell regeneration.
PLANT CELL REPORTS
(2023)
Review
Plant Sciences
Jie Liu, Meng Ke, Yuhan Sun, Shihui Niu, Wenli Zhang, Yun Li
Summary: Plant rejuvenation involves resetting gene expression patterns, chromatin remodeling, and histone modifications, resulting in the restoration of juvenile characteristics. The epigenetic mechanisms underlying this process are still in the early stages of study.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Cell Biology
Shihang Zhou, Hongliang Zeng, Jinhua Huang, Li Lei, Xiaoliang Tong, Si Li, Ying Zhou, Haoran Guo, Manal Khan, Liping Luo, Rong Xiao, Jing Chen, Qinghai Zeng
Summary: Melanogenesis is a complex process involving multiple genes and signaling pathways, with epigenetics playing a key role in regulating the expression of key genes. Epigenetic-based therapy provides novel opportunities for treating dermatoses caused by pigmentation disturbances.
AGEING RESEARCH REVIEWS
(2021)
Review
Genetics & Heredity
Jinkun Xia, Wangsen Cao
Summary: Studies show that epigenetic modifications affect the Klotho gene in renal diseases, impacting disease progression. Lowered Klotho levels worsen the condition, but beneficial changes can be made through epigenetic interventions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Oncology
Junyuan Xie, Li Gan, Bingjian Xue, Xinxing Wang, Xinhong Pei
Summary: Breast cancer remains the leading cause of cancer-related death in women worldwide. Non-coding RNAs, especially lncRNAs, have been found to play important roles in breast cancer. The study of epigenetic modifications has also contributed to the understanding of the role of ncRNAs in breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Environmental Sciences
Bozena Bukowska, Ewelina Wozniak, Paulina Sicinska, Katarzyna Mokra, Jaromir Michalowicz
Summary: Glyphosate has been shown to induce epigenetic changes that may be associated with carcinogenesis. These changes include alterations in DNA methylation, gene expression, chromatin structure, and the regulation of non-coding RNA molecules. These epigenetic changes can persist over time and be passed on to future generations, potentially leading to the development of diseases such as prostate disease or obesity. More research is needed to fully understand the metabolic effects of these changes on organisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Neurosciences
Jean Lud Cadet, Subramaniam Jayanthi
Summary: This review discusses the evidence of methamphetamine exposure causing changes in epigenetic modifications and the correlations between these changes and behavioral alterations. Studies on rats have shown associations between prolonged methamphetamine self-administration with compulsive drug-taking and abstinent phenotypes, as well as increased DNA hydroxymethylation and mRNA expression in genes encoding potassium channels in the nucleus accumbens. Further research is needed to understand how pharmacological or genetic manipulations of epigenetic alterations and potassium channel expression can affect methamphetamine-taking behaviors and relapse after long periods of abstinence.
CURRENT NEUROPHARMACOLOGY
(2021)
Review
Immunology
Liangjie Xu, Cuicui Zhou, Yi Liang, Tinpan Fan, Fen Zhang, Xinxin Chen, Wei Yuan
Summary: This article reviews the interaction between epigenetic modifications and the functions of myeloid-derived suppressor cells (MDSCs), and briefly introduces how the accumulation and function of MDSCs caused by epigenetic modifications impact disease development, providing a promising therapeutic strategy for related disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Qian Xiang, Yongzhao Zhao, Jialiang Lin, Shuai Jiang, Weishi Li
Summary: This study systematically discusses the different epigenetic modifications and their potential functions in the process of spinal ligament aging.
AGEING RESEARCH REVIEWS
(2022)