Deregulation of ribosomal proteins in human cancers

Cancer-associated mutations in the ribosomal protein L5 gene dysregulate the HDM2/p53-mediated ribosome biogenesis checkpoint

(2020) Ines Oršolić et al.   ONCOGENE

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis

(2020) Richard Y. Ebright et al.   SCIENCE

Involvement of ribosomal protein L11 expression in sensitivity of gastric cancer against 5‑FU

(2020) Takuto Kawahata et al.   Oncology Letters

Ribosomal protein S6 promotes stem‐like characters in glioma cells

(2020) Yuki Shirakawa et al.   CANCER SCIENCE

Role of uL3 in the Crosstalk between Nucleolar Stress and Autophagy in Colon Cancer Cells

(2020) Annalisa Pecoraro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Colocalization of MID1IP1 and c-Myc is Critically Involved in Liver Cancer Growth via Regulation of Ribosomal Protein L5 and L11 and CNOT2

(2020) Ji Hoon Jung et al.   Cells

Ribosomal protein S3 selectively affects colon cancer growth by modulating the levels of p53 and lactate dehydrogenase

(2020) Elie Alam et al.   MOLECULAR BIOLOGY REPORTS

Biological effect of ribosomal protein L32 on human breast cancer cell behavior

(2020) Lu Xu et al.   Molecular Medicine Reports

Identification of 40S ribosomal protein S8 as a novel biomarker for alcohol‑associated hepatocellular carcinoma using weighted gene co‑expression network analysis

(2020) Ningrui Bi et al.   ONCOLOGY REPORTS

TRPM7/RPSA Complex Regulates Pancreatic Cancer Cell Migration

(2020) Thibaut Lefebvre et al.   Frontiers in Cell and Developmental Biology

Inactivation of ribosomal protein S27-like impairs DNA interstrand cross-link repair by destabilization of FANCD2 and FANCI

(2020) Siyuan Sun et al.   Cell Death & Disease

MicroRNA-587 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting Ribosomal Protein SA

(2020) Miao Chen et al.   Biomed Research International

RPL21 siRNA Blocks Proliferation in Pancreatic Cancer Cells by Inhibiting DNA Replication and Inducing G1 Arrest and Apoptosis

(2020) Chaodong Li et al.   Frontiers in Oncology

Identification of ribosomal protein family in triple-negative breast cancer by bioinformatics analysis

(2020) Ziyue Lin et al.   BIOSCIENCE REPORTS

RPS15A promotes gastric cancer progression via activation of the Akt/IKK-β/NF-κB signalling pathway

(2019) Chenchen Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Ribosome Biogenesis—Cancer Connection

(2019) Marianna Penzo et al.   Cells

RPS7 promotes cell migration through targeting epithelial-mesenchymal transition in prostate cancer

(2019) Yingwu Wen et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

ITGA6 and RPSA synergistically promote pancreatic cancer invasion and metastasis via PI3K and MAPK signaling pathways

(2019) Yunhao Wu et al.   EXPERIMENTAL CELL RESEARCH

The Ribosomal Protein RPLP0 Mediates PLAAT4-induced Cell Cycle Arrest and Cell Apoptosis

(2019) Chun-Hua Wang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Overexpression of microRNA-519d-3p suppressed the growth of pancreatic cancer cells by inhibiting ribosomal protein S15A-mediated Wnt/β-catenin signaling

(2019) Jing Liang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Identification of candidate diagnostic and prognostic biomarkers for human prostate cancer: RPL22L1 and RPS21

(2019) Zumu Liang et al.   MEDICAL ONCOLOGY

Ribosomal protein small subunit 15A (RPS15A) inhibits the apoptosis of breast cancer MDA‐MB‐231 cells via upregulating phosphorylated ERK1/2, Bad, and Chk1

(2019) Lingsuo Kong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Metallopanstimulin-1 (MPS-1) mediates the promotion effect of leptin on colorectal cancer through activation of JNK/c-Jun signaling pathway

(2019) Dongxing Cao et al.   Cell Death & Disease

Germline variability and tumor expression level of ribosomal protein gene RPL28 are associated with survival of metastatic colorectal cancer patients

(2019) Adrien Labriet et al.   Scientific Reports

Diagnostic and prognostic implications of ribosomal protein transcript expression patterns in human cancers

(2018) James M. Dolezal et al.   BMC CANCER

Suppression of ribosomal protein RPS6KB1 by Nexrutine increases sensitivity of prostate tumors to radiation

(2018) Suleman S. Hussain et al.   CANCER LETTERS

Knockdown of ribosomal protein S15A inhibits proliferation of breast cancer cells through induction of apoptosis in vitro

(2018) Weiliang Feng et al.   CYTOTECHNOLOGY

Germline Duplication of SNORA18L5 Increases Risk for HBV-related Hepatocellular Carcinoma by Altering Localization of Ribosomal Proteins and Decreasing Levels of p53

(2018) Pengbo Cao et al.   GASTROENTEROLOGY

The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL

(2018) Kim R. Kampen et al.   LEUKEMIA

Kinase PIM1 promotes prostate cancer cell growth via c-Myc-RPS7-driven ribosomal stress

(2018) Changwen Zhang et al.   CARCINOGENESIS

Identification of the key genes and pathways in prostate cancer

(2018) Shutong Fan et al.   Oncology Letters

NRF2 through RPS6 Activation Is Related to Anti-HER2 Drug Resistance in HER2-Amplified Gastric Cancer

(2018) Valentina Gambardella et al.   CLINICAL CANCER RESEARCH

The roles of moonlight ribosomal proteins in the development of human cancers

(2018) Ghader Molavi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

RNA-binding protein RPS3 contributes to hepatocarcinogenesis by post-transcriptionally up-regulating SIRT1

(2018) Lijun Zhao et al.   NUCLEIC ACIDS RESEARCH

Ribosomal protein S27-like regulates autophagy via the β-TrCP-DEPTOR-mTORC1 axis

(2018) Xiufang Xiong et al.   Cell Death & Disease

The Ribosomal Protein S19 Suppresses Antitumor Immune Responses via the Complement C5a Receptor 1

(2017) Maciej M. Markiewski et al.   JOURNAL OF IMMUNOLOGY

Ribosomal proteins: insight into molecular roles and functions in hepatocellular carcinoma

(2017) X Xie et al.   ONCOGENE

Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/β-catenin-induced FGF18 expression in hepatocellular carcinoma

(2017) Pengyi Guo et al.   ONCOGENE

Ribosomal protein S3 regulates XIAP expression independently of the NF-κB pathway in breast cancer cells

(2017) Hisako Ono et al.   ONCOLOGY REPORTS

Silencing of Ribosomal Protein L34 (RPL34) Inhibits the Proliferation and Invasion of Esophageal Cancer Cells

(2017) Huijie Fan et al.   ONCOLOGY RESEARCH

The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types

(2017) Laura Fancello et al.   Oncotarget

Cooperative down-regulation of ribosomal protein L10 and NF-κB signaling pathway is responsible for the anti-proliferative effects by DMAPT in pancreatic cancer cells

(2017) Chen Shi et al.   Oncotarget

The uS8, uS4, eS31, and uL14 Ribosomal Protein Genes Are Dysregulated in Nasopharyngeal Carcinoma Cell Lines

(2017) Edmund Ui-Hang Sim et al.   Biomed Research International

Expression of ribosomal proteins in normal and cancerous human prostate tissue

(2017) Callum Arthurs et al.   PLoS One

Over-expressed RPL34 promotes malignant proliferation of non-small cell lung cancer cells

(2016) Shaoxing Yang et al.   GENE

Knockdown of RPL9 expression inhibits colorectal carcinoma growth via the inactivation of Id-1/NF-κB signaling axis

(2016) In Hye Baik et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Ribosomal protein S15A promotes malignant transformation and predicts poor outcome in colorectal cancer through misregulation of p53 signaling pathway

(2016) JINGWEN CHEN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Role of ribosomal protein mutations in tumor development (Review)

(2016) KAVEH M. GOUDARZI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Genome-wide assessment of differential translations with ribosome profiling data

(2016) Zhengtao Xiao et al.   Nature Communications

Ribosomal protein L34 promotes the proliferation, invasion and metastasis of pancreatic cancer cells

(2016) Feng Wei et al.   Oncotarget

Enhancement of 5-FU sensitivity by the proapoptotic rpL3 gene in p53 null colon cancer cells through combined polymer nanoparticles

(2016) Annapina Russo et al.   Oncotarget

The Evolution of the Ribosomal Protein–MDM2–p53 Pathway

(2016) Chad Deisenroth et al.   Cold Spring Harbor Perspectives in Medicine

rpL3 promotes the apoptosis of p53 mutated lung cancer cells by down-regulating CBS and NFκB upon 5-FU treatment

(2016) Annapina Russo et al.   Scientific Reports

Serum Anti-60S Ribosomal Protein L29 Antibody as a Novel Prognostic Marker for Unresectable Pancreatic Cancer

(2015) Shinichiro Muro et al.   DIGESTION

RPS24 knockdown inhibits colorectal cancer cell migration and proliferation in vitro

(2015) Yue Wang et al.   GENE

Dual inhibition of EGFR and MET induces synthetic lethality in triple-negative breast cancer cells through downregulation of ribosomal protein S6

(2015) YONG WEON YI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Dissociation of MIF-rpS3 Complex and Sequential NF-κB Activation Is Involved in IR-Induced Metastatic Conversion of NSCLC

(2015) HyeSook Youn et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hyperphosphorylation of ribosomal protein S6 predicts unfavorable clinical survival in non-small cell lung cancer

(2015) Bojiang Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Decreased expression of RPS15A suppresses proliferation of lung cancer cells

(2015) Xinmin Zhao et al.   TUMOR BIOLOGY

Ribosomal proteins: functions beyond the ribosome

(2015) Xiang Zhou et al.   Journal of Molecular Cell Biology

Downregulation of RPL15 may predict poor survival and associate with tumor progression in pancreatic ductal adenocarcinoma

(2015) Ting-Ting Yan et al.   Oncotarget

RPS7 inhibits colorectal cancer growth via decreasing HIF-1α-mediated glycolysis

(2015) Wen Zhang et al.   Oncotarget

RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth

(2015) Kathleen A. Wilson-Edell et al.   Oncotarget

Ribosomal protein L19 overexpression activates the unfolded protein response and sensitizes MCF7 breast cancer cells to endoplasmic reticulum stress-induced cell death

(2014) Mina Hong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Knockdown of ribosomal protein L39 by RNA interference inhibits the growth of human pancreatic cancer cells in vitro and in vivo

(2014) Chaa odong Li et al.   Biotechnology Journal

Inverse correlation of ribosomal protein S27A and multifunctional protein YB-1 in hepatocellular carcinoma

(2014) Vinoth Prasanna Gunasekaran et al.   CLINICAL BIOCHEMISTRY

Germline Mutation of RPS20, Encoding a Ribosomal Protein, Causes Predisposition to Hereditary Nonpolyposis Colorectal Carcinoma Without DNA Mismatch Repair Deficiency

(2014) Taina T. Nieminen et al.   GASTROENTEROLOGY

Proteins associated with pancreatic cancer survival in patients with resectable pancreatic ductal adenocarcinoma

(2014) Ru Chen et al.   LABORATORY INVESTIGATION

Palmatine inhibits growth and invasion in prostate cancer cell: Potential role for rpS6/NFκB/FLIP

(2014) Heather G. Hambright et al.   MOLECULAR CARCINOGENESIS

Short Hairpin RNA Library-Based Functional Screening Identified Ribosomal Protein L31 That Modulates Prostate Cancer Cell Growth via p53 Pathway

(2014) Yojiro Maruyama et al.   PLoS One

Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling

(2014) B. Dave et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RPL39L is an example of a recently evolved ribosomal protein paralog that shows highly specific tissue expression patterns and is upregulated in ESCs and HCC tumors

(2014) Queenie Wing-Lei Wong et al.   RNA Biology

The ever-evolving role of mTOR in translation

(2014) Bruno D. Fonseca et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pair-wise comparison analysis of differential expression of mRNAs in early and advanced stage primary colorectal adenocarcinomas

(2014) T. P. Lau et al.   BMJ Open

Phosphorylation of Ribosomal Protein S6 Attenuates DNA Damage and Tumor Suppression during Development of Pancreatic Cancer

(2013) A. Khalaileh et al.   CANCER RESEARCH

Metallopanstimulin-1 regulates invasion and migration of gastric cancer cells partially through integrin β4

(2013) Zhong-Yin Yang et al.   CARCINOGENESIS

Down-regulation of ribosomal protein S15A mRNA with a short hairpin RNA inhibits human hepatic cancer cell growth in vitro

(2013) Maiyu Xu et al.   GENE

Down-regulation of ribosomal protein L22 in non-small cell lung cancer

(2013) Mingxia Yang et al.   MEDICAL ONCOLOGY

Ribosomal Protein S27-Like in Colorectal Cancer: A Candidate for Predicting Prognoses

(2013) Chi-Jung Huang et al.   PLoS One

The Flavonoid Apigenin Downregulates CDK1 by Directly Targeting Ribosomal Protein S9

(2013) Yosuke Iizumi et al.   PLoS One

Small Ribosomal Protein Subunit S7 Suppresses Ovarian Tumorigenesis through Regulation of the PI3K/AKT and MAPK Pathways

(2013) Ziliang Wang et al.   PLoS One

Phosphorylation of Ribosomal Protein S3 and Antiapoptotic TRAF2 Protein Mediates Radioresistance in Non-small Cell Lung Cancer Cells

(2012) Hee Jung Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silencing expression of ribosomal protein L26 and L29 by RNA interfering inhibits proliferation of human pancreatic cancer PANC-1 cells

(2012) Chaodong Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Retraction: Role of Ribosomal Protein RPS2 in Controlling let-7a Expression in Human Prostate Cancer

(2012)   MOLECULAR CANCER RESEARCH

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

(2012) Kim De Keersmaecker et al.   NATURE GENETICS

A Novel Interaction Between Interferon-Inducible Protein p56 and Ribosomal Protein L15 in Gastric Cancer Cells

(2011) Yu-An Hsu et al.   DNA AND CELL BIOLOGY

The HBx protein of hepatitis B virus regulates the expression, intracellular distribution and functions of ribosomal protein S27a

(2011) G. Fatima et al.   JOURNAL OF GENERAL VIROLOGY

RPL36 as a prognostic marker in hepatocellular carcinoma

(2011) Myeong Jun Song et al.   PATHOLOGY INTERNATIONAL

siRNA Knockdown of Ribosomal Protein Gene RPL19 Abrogates the Aggressive Phenotype of Human Prostate Cancer

(2011) Alix Bee et al.   PLoS One

RPS3a Over-Expressed in HBV-Associated Hepatocellular Carcinoma Enhances the HBx-Induced NF-κB Signaling via Its Novel Chaperoning Function

(2011) Keo-Heun Lim et al.   PLoS One

Downregulation of RPL6 by siRNA Inhibits Proliferation and Cell Cycle Progression of Human Gastric Cancer Cell Lines

(2011) Qiong Wu et al.   PLoS One

Guarding the ‘translation apparatus’: defective ribosome biogenesis and the p53 signaling pathway

(2011) Anirban Chakraborty et al.   Wiley Interdisciplinary Reviews-RNA

Ribosomal protein L6 promotes growth and cell cycle progression through upregulating cyclin E in gastric cancer cells

(2010) Yawen Gou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma

(2010) Diego F. Calvisi et al.   GASTROENTEROLOGY

Immunohistochemical examination of the mTORC1 pathway in high grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinomas (PCa): A tissue microarray study (TMA)

(2010) Sevan Evren et al.   PROSTATE

Identification of ribosomal protein L19 as a novel tumor antigen recognized by autologous cytotoxic T lymphocytes in lung adenocarcinoma

(2009) Koji Kuroda et al.   CANCER SCIENCE

Human ribosomal protein S13 promotes gastric cancer growth through down-regulating p27Kip1

(2009) Xueyan Guo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Faecal ribosomal protein L19 is a genetic prognostic factor for survival in colorectal cancer

(2008) C.-J Huang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Distinct expression patterns in hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma

(2008) Chun-Feng Lee et al.   WORLD JOURNAL OF GASTROENTEROLOGY