Divergent synthesis and elaboration of structure activity relationship for quinoline derivatives as highly selective NTPDase inhibitor

Imatinib mesylate affects extracellular ATP catabolism and expression of NTPDases in a chronic myeloid leukemia cell line

(2020) Julia Biz Willig et al.   Purinergic Signalling

Ectonucleoside Triphosphate Diphosphohydrolase-1/CD39 Affects the Response to ADP of Female Rat Platelets

(2020) Elisabetta Caiazzo et al.   Frontiers in Pharmacology

Biochemical analysis of ectonucleotidases on primary rat vascular smooth muscle cells and in silico investigation of their role in vascular diseases

(2020) Ana Paula Santin Bertoni et al.   LIFE SCIENCES

A Combine Approach of Chemical Synthesis, Biological Evaluation and Structural Dynamics Studies Revealed Thiazole Substituted Arylamine Derivatives as Potent FabH Enzyme Inhibitors

(2020) Haseen Ahmad et al.   BIOORGANIC CHEMISTRY

Development of Anthraquinone Derivatives as Ectonucleoside Triphosphate Diphosphohydrolase (NTPDase) Inhibitors With Selectivity for NTPDase2 and NTPDase3

(2020) Younis Baqi et al.   Frontiers in Pharmacology

Nucleotide Analog ARL67156 as a Lead Structure for the Development of CD39 and Dual CD39/CD73 Ectonucleotidase Inhibitors

(2020) Laura Schäkel et al.   Frontiers in Pharmacology

Synthesis of biphenyl oxazole derivatives via Suzuki coupling and biological evaluations as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors

(2020) Haseen Ahmad et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Investigation of new quinoline derivatives as promising inhibitors of NTPDases: Synthesis, SAR analysis and molecular docking studies

(2019) Komal Hayat et al.   BIOORGANIC CHEMISTRY

Adenosine Metabolism: Emerging Concepts for Cancer Therapy

(2019) Detlev Boison et al.   CANCER CELL

Zebrafish models: Gaining insight into purinergic signaling and neurological disorders

(2019) Débora Dreher Nabinger et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Modification of Bischler-Möhlau indole derivatives through palladium catalyzed Suzuki reaction as effective cholinesterase inhibitors, their kinetic and molecular docking studies

(2018) Shaista Parveen et al.   BIOORGANIC CHEMISTRY

NTPDase activities: possible roles on Leishmania spp infectivity and virulence

(2018) Lisvane Paes-Vieira et al.   CELL BIOLOGY INTERNATIONAL

Molecular dynamic simulations reveal structural insights into substrate and inhibitor binding modes and functionality of Ecto-Nucleoside Triphosphate Diphosphohydrolases

(2018) Jamshed Iqbal et al.   Scientific Reports

The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases

(2018) Margarete Dulce Bagatini et al.   Journal of Immunology Research

Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis

(2018) Diane C. Saunders et al.   Cell Metabolism

Koala and wombat gammaherpesviruses encode the first known viral nucleoside triphosphate diphosphohydrolase (NTPDase) homologs and are phylogenetically divergent from all known gammaherpesviruses.

(2018) Paola K. Vaz et al.   JOURNAL OF VIROLOGY

Highly efficient reduction of nitro compounds: Recyclable Pd/C-catalyzed transfer hydrogenation with ammonium formate or hydrazine hydrate as hydrogen source

(2018) Xia Chen et al.   SYNTHETIC COMMUNICATIONS

Synthesis of novel quinoline-based thiadiazole, evaluation of their antileishmanial potential and molecular docking studies

(2018) Noor Barak Almandil et al.   BIOORGANIC CHEMISTRY

Synthesis, in vitro β -glucuronidase inhibitory potential and molecular docking studies of quinolines

(2017) Bilquees Bano et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

(2017) Bertrand Allard et al.   IMMUNOLOGICAL REVIEWS

NTPDase, 5′-nucleotidase and adenosine deaminase activities and purine levels in serum of sickle cell anemia patients

(2017) Lívia G. Castilhos et al.   Journal of Applied Biomedicine

Purinergic signaling during intestinal inflammation

(2017) Maria Serena Longhi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Generation and characterization of polyclonal and monoclonal antibodies to human NTPDase2 including a blocking antibody

(2017) Julie Pelletier et al.   Purinergic Signalling

Distinct roles of ecto-nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in liver regeneration and fibrosis

(2017) Linda Feldbrügge et al.   Purinergic Signalling

Various N-glycoforms differentially upregulate E-NTPDase activity of the NTPDase3/CD39L3 ecto-enzymatic domain

(2017) Alexander H. Zhong et al.   Purinergic Signalling

Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) and its inhibitors

(2017) Sang-Yong Lee et al.   MedChemComm

Purinergic Receptors in Adipose Tissue As Potential Targets in Metabolic Disorders

(2017) Marco Tozzi et al.   Frontiers in Pharmacology

Substrate-Dependence of Competitive Nucleotide Pyrophosphatase/Phosphodiesterase1 (NPP1) Inhibitors

(2017) Sang-Yong Lee et al.   Frontiers in Pharmacology

Generation and Characterization of Specific Antibodies to the Murine and Human Ectonucleotidase NTPDase8

(2017) Julie Pelletier et al.   Frontiers in Pharmacology

Synthesis and biological evaluation of novel N-arylidenequinoline-3-carbohydrazides as potent β-glucuronidase inhibitors

(2016) Muhammad Taha et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Purinergic Receptors in Thrombosis and Inflammation

(2015) Béatrice Hechler et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Is Ecto-nucleoside Triphosphate Diphosphohydrolase (NTPDase)-based Therapy of Central Nervous System Disorders Possible?

(2015) Katarzyna Roszek et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Ecto-Nucleotidase Inhibitors: Recent Developments in Drug Discovery

(2015) Younis Baqi   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Crystal structure of NTPDase2 in complex with the sulfoanthraquinone inhibitor PSB-071

(2014) Matthias Zebisch et al.   JOURNAL OF STRUCTURAL BIOLOGY

Ticlopidine in Its Prodrug Form Is a Selective Inhibitor of Human NTPDase1

(2014) Joanna Lecka et al.   MEDIATORS OF INFLAMMATION

8-BuS-ATP derivatives as specific NTPDase1 inhibitors

(2013) Joanna Lecka et al.   BRITISH JOURNAL OF PHARMACOLOGY

Localization of plasma membrane bound NTPDases in the murine reproductive tract

(2009) M. Martín-Satué et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Selective Nucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2) Inhibitors: Nucleotide Mimetics Derived from Uridine-5′-carboxamide†

(2008) Andreas Brunschweiger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-activity relationships of anthraquinone derivatives derived from bromaminic acid as inhibitors of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases)

(2008) Younis Baqi et al.   Purinergic Signalling