Development of Anthraquinone Derivatives as Ectonucleoside Triphosphate Diphosphohydrolase (NTPDase) Inhibitors With Selectivity for NTPDase2 and NTPDase3

The Purinergic System as a Pharmacological Target for the Treatment of Immune-Mediated Inflammatory Diseases

(2019) Luca Antonioli et al.   PHARMACOLOGICAL REVIEWS

Purinergic Signaling in Pulmonary Inflammation

(2019) Thanh-Thuy T. Le et al.   Frontiers in Immunology

The therapeutic potential of purinergic signalling

(2018) Geoffrey Burnstock   BIOCHEMICAL PHARMACOLOGY

Extracellular ATP signaling and clinical relevance

(2018) Lei Dou et al.   CLINICAL IMMUNOLOGY

Schiff bases of tryptamine as potent inhibitors of nucleoside triphosphate diphosphohydrolases (NTPDases): Structure-activity relationship

(2018) Kanwal et al.   BIOORGANIC CHEMISTRY

Development of Potent and Selective Antagonists for the UTP-Activated P2Y4 Receptor

(2017) Muhammad Rafehi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Recognition of Agonists and Antagonists by the Nucleotide-Activated G Protein-Coupled P2Y2 Receptor

(2017) Muhammad Rafehi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Generation and characterization of polyclonal and monoclonal antibodies to human NTPDase2 including a blocking antibody

(2017) Julie Pelletier et al.   Purinergic Signalling

Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) and its inhibitors

(2017) Sang-Yong Lee et al.   MedChemComm

Inhibitors for the bacterial ectonucleotidase Lp1NTPDase from Legionella pneumophila

(2016) Amelie Fiene et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Anthraquinones as a privileged scaffold in drug discovery targeting nucleotide-binding proteins

(2016) Younis Baqi   DRUG DISCOVERY TODAY

Ullmann reactions of 1-amino-4-bromoanthraquinones bearing various 2-substituents furnishing novel dyes

(2016) Enas M. Malik et al.   DYES AND PIGMENTS

Expression of ecto-nucleoside triphosphate diphosphohydrolase3 (NTPDase3) in the female rat brain during postnatal development

(2016) Ivana Grković et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Anthraquinones As Pharmacological Tools and Drugs

(2016) Enas M. Malik et al.   MEDICINAL RESEARCH REVIEWS

Fluorescence polarization immunoassays for monitoring nucleoside triphosphate diphosphohydrolase (NTPDase) activity

(2015) Amelie Fiene et al.   ANALYST

Inhibition of Alkaline Phosphatase: An Emerging New Drug Target

(2015) Mariya Rashida et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Ecto-Nucleotidase Inhibitors: Recent Developments in Drug Discovery

(2015) Younis Baqi   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Crystal structure of NTPDase2 in complex with the sulfoanthraquinone inhibitor PSB-071

(2014) Matthias Zebisch et al.   JOURNAL OF STRUCTURAL BIOLOGY

NTPDase2 and Purinergic Signaling Control Progenitor Cell Proliferation in Neurogenic Niches of the Adult Mouse Brain

(2014) Kristine Gampe et al.   STEM CELLS

8-BuS-ATP derivatives as specific NTPDase1 inhibitors

(2013) Joanna Lecka et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ectonucleotidases and Nucleotide/Nucleoside Transporters as Pharmacological Targets for Neurological Disorders

(2012) Carla D. Bonan   CNS & Neurological Disorders-Drug Targets

The medial habenula contains a specific nonstellate subtype of astrocyte expressing the ectonucleotidase NTPDase2

(2012) Kristine Gampe et al.   GLIA

Cellular function and molecular structure of ecto-nucleotidases

(2012) Herbert Zimmermann et al.   Purinergic Signalling

Efficient and mild deamination procedure for 1-aminoanthraquinones yielding a diverse library of novel derivatives with potential biological activity

(2012) Younis Baqi et al.   TETRAHEDRON LETTERS

Discovery of Potent Competitive Antagonists and Positive Modulators of the P2X2 Receptor

(2011) Younis Baqi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of Potent and Selective Inhibitors ofecto-5′-Nucleotidase Based on an Anthraquinone Scaffold

(2010) Younis Baqi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of alkyl- and aryl-amino-substituted anthraquinone derivatives by microwave-assisted copper(0)-catalyzed Ullmann coupling reactions

(2010) Younis Baqi et al.   Nature Protocols

High-Affinity, Non-Nucleotide-Derived Competitive Antagonists of Platelet P2Y12Receptors

(2009) Younis Baqi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of a monoclonal antibody as the first specific inhibitor of human NTP diphosphohydrolase-3

(2008) Mercedes N. Munkonda et al.   FEBS Journal

Selective Nucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2) Inhibitors: Nucleotide Mimetics Derived from Uridine-5′-carboxamide†

(2008) Andreas Brunschweiger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-activity relationships of anthraquinone derivatives derived from bromaminic acid as inhibitors of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases)

(2008) Younis Baqi et al.   Purinergic Signalling

Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists

(2007) Stefanie Weyler et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS