Nucleotide Analog ARL67156 as a Lead Structure for the Development of CD39 and Dual CD39/CD73 Ectonucleotidase Inhibitors

Recombinant expression of ecto-nucleotide pyrophosphatase/phosphodiesterase 4 (NPP4) and development of a luminescence-based assay to identify inhibitors

(2020) Vittoria Lopez et al.   ANALYTICAL BIOCHEMISTRY

The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment

(2019) Elena De Marchi et al.   ONCOGENE

Structure–Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5′-Nucleotidase (CD73) Inhibitors

(2019) Anna Junker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functional insights into nucleotide-metabolizing ectoenzymes expressed by bone marrow-resident cells in patients with multiple myeloma

(2018) A.L. Horenstein et al.   IMMUNOLOGY LETTERS

Schiff bases of tryptamine as potent inhibitors of nucleoside triphosphate diphosphohydrolases (NTPDases): Structure-activity relationship

(2018) Kanwal et al.   BIOORGANIC CHEMISTRY

The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

(2017) Bertrand Allard et al.   IMMUNOLOGICAL REVIEWS

Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) and its inhibitors

(2017) Sang-Yong Lee et al.   MedChemComm

Substrate-Dependence of Competitive Nucleotide Pyrophosphatase/Phosphodiesterase1 (NPP1) Inhibitors

(2017) Sang-Yong Lee et al.   Frontiers in Pharmacology

Polyoxometalates—Potent and selective ecto-nucleotidase inhibitors

(2015) Sang-Yong Lee et al.   BIOCHEMICAL PHARMACOLOGY

CD39+regulatory T cells attenuate allergic airway inflammation

(2015) P. Li et al.   CLINICAL AND EXPERIMENTAL ALLERGY

α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5′-Nucleotidase (CD73) Inhibitors

(2015) Sanjay Bhattarai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transition State in DNA Polymerase β Catalysis: Rate-Limiting Chemistry Altered by Base-Pair Configuration

(2014) Keriann Oertell et al.   BIOCHEMISTRY

Inhibition of glioma progression by a newly discovered CD38 inhibitor

(2014) Eran Blacher et al.   INTERNATIONAL JOURNAL OF CANCER

Isomorphic Emissive GTP Surrogate Facilitates Initiation and Elongation of in Vitro Transcription Reactions

(2014) Lisa S. McCoy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Differential impact of adenosine nucleotides released by osteocytes on breast cancer growth and bone metastasis

(2014) J Z Zhou et al.   ONCOGENE

Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity

(2014) J. Bastid et al.   Cancer Immunology Research

A new, sensitive ecto-5′-nucleotidase assay for compound screening

(2013) Marianne Freundlieb et al.   ANALYTICAL BIOCHEMISTRY

8-BuS-ATP derivatives as specific NTPDase1 inhibitors

(2013) Joanna Lecka et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ecto-5'-Nucleotidase (CD73)-Mediated Formation of Adenosine Is Critical for the Striatal Adenosine A2A Receptor Functions

(2013) E. Augusto et al.   JOURNAL OF NEUROSCIENCE

Immunoregulation through extracellular nucleotides

(2012) L. Vitiello et al.   BLOOD

Cellular function and molecular structure of ecto-nucleotidases

(2012) Herbert Zimmermann et al.   Purinergic Signalling

Selective Activation of Adenosine A2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid Arthritis

(2012) U. Flogel et al.   Science Translational Medicine

The optimized microwave-assisted decomposition of formamides and its synthetic utility in the amination reactions of purines

(2010) Lucie Čechová et al.   TETRAHEDRON

Generation and Accumulation of Immunosuppressive Adenosine by Human CD4+CD25highFOXP3+Regulatory T Cells

(2009) Magis Mandapathil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleoside-5′-monophosphates as Prodrugs of Adenosine A2AReceptor Agonists Activated by ecto-5′-Nucleotidase†† Contribution to celebrate the 100th anniversary of the Division of Medicinal Chemistry of the American Chemical Society.

(2009) Ali El-Tayeb et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-activity relationships of anthraquinone derivatives derived from bromaminic acid as inhibitors of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases)

(2008) Younis Baqi et al.   Purinergic Signalling