Development and biological evaluation of AzoBGNU: A novel hypoxia-activated DNA crosslinking prodrug with AGT-inhibitory activity

Mimicking tumor hypoxia and tumor-immune interactions employing three-dimensional in vitro models

(2020) Somshuvra Bhattacharya et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Three-Dimensional Cell Cultures as an In Vitro Tool for Prostate Cancer Modeling and Drug Discovery

(2020) Fabrizio Fontana et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research

(2020) Bárbara Pinto et al.   Pharmaceutics

DNA repair in personalized brain cancer therapy with temozolomide and nitrosoureas

(2019) Bernd Kaina et al.   DNA REPAIR

An azobenzene-based heteromeric prodrug for hypoxia-activated chemotherapy by regulating subcellular localization

(2018) Shiying Li et al.   CHEMICAL COMMUNICATIONS

The specific role of O6-methylguanine-DNA methyltransferase inhibitors in cancer chemotherapy

(2018) Guohui Sun et al.   Future Medicinal Chemistry

NBGNU: a hypoxia-activated tripartite combi-nitrosourea prodrug overcoming AGT-mediated chemoresistance

(2018) Yao Ge et al.   Future Medicinal Chemistry

Synthesis and Antitumor Activity Evaluation of a Novel Combi-nitrosourea Prodrug: BGCNU

(2017) Yameng Wang et al.   ACS Medicinal Chemistry Letters

Synthesis and antitumor activity evaluation of a novel combi-nitrosourea prodrug: Designed to release a DNA cross-linking agent and an inhibitor of O6-alkylguanine-DNA alkyltransferase

(2016) Guohui Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chemotherapy with BCNU in recurrent glioma: Analysis of clinical outcome and side effects in chemotherapy-naïve patients

(2016) Christine Jungk et al.   BMC CANCER

Hypoxia-Driven Mechanism of Vemurafenib Resistance in Melanoma

(2016) Y. Qin et al.   MOLECULAR CANCER THERAPEUTICS

Identification of the Structural Features of Guanine Derivatives as MGMT Inhibitors Using 3D-QSAR Modeling Combined with Molecular Docking

(2016) Guohui Sun et al.   MOLECULES

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

(2016) Caroline Wigerup et al.   PHARMACOLOGY & THERAPEUTICS

Investigations on the Effect of O6-Benzylguanine on the Formation of dG-dC Interstrand Cross-Links Induced by Chloroethylnitrosoureas in Human Glioma Cells Using Stable Isotope Dilution High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry

(2014) Guohui Sun et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Phase II Study of the Safety and Antitumor Activity of the Hypoxia-Activated Prodrug TH-302 in Combination With Doxorubicin in Patients With Advanced Soft Tissue Sarcoma

(2014) Sant P. Chawla et al.   JOURNAL OF CLINICAL ONCOLOGY

Quantification of DNA interstrand crosslinks induced by ACNU in NIH/3T3 and L1210 cells using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry

(2014) Lili Li et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Porous chitosan-hyaluronic acid scaffolds as a mimic of glioblastoma microenvironment ECM

(2013) Stephen J. Florczyk et al.   BIOMATERIALS

Quantitation of Pyridyloxobutyl-DNA Adducts in Tissues of Rats Treated Chronically with (R)- or (S)-N′-Nitrosonornicotine (NNN) in a Carcinogenicity Study

(2013) Lijiao Zhao et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Advances in the development of hybrid anticancer drugs

(2013) Sébastien Fortin et al.   Expert Opinion on Drug Discovery

Synthesis of trans- and cis-4′-Hydroxylomustine and Development of Validated Analytical Method for Lomustine and trans- and cis-4′-Hydroxylomustine in Canine Plasma

(2013) L. Dirikolu et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Hypoxia-Selective O6-Alkylguanine-DNA Alkyltransferase Inhibitors: Design, Synthesis, and Evaluation of 6-(Benzyloxy)-2-(aryldiazenyl)-9H-purines as Prodrugs of O6-Benzylguanine

(2013) Rui Zhu et al.   JOURNAL OF MEDICINAL CHEMISTRY

EO9 (Apaziquone): from the clinic to the laboratory and back again

(2012) Roger M Phillips et al.   BRITISH JOURNAL OF PHARMACOLOGY

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

(2012) Wynand P. Roos et al.   CANCER LETTERS

Chloroethylnitrosourea-induced cell death and genotoxicity: Cell cycle dependence and the role of DNA double-strand breaks, HR and NHEJ

(2012) Teodora Nikolova et al.   CELL CYCLE

A density functional theory investigation on the formation mechanisms of DNA interstrand crosslinks induced by chloroethylnitrosoureas

(2012) Li-Jiao Zhao et al.   INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY

Comparative theoretical investigation of the formation of DNA interstrand crosslinks induced by two kinds ofN-nitroso compounds: nitrosoureas and nitrosamines

(2012) Lijiao Zhao et al.   JOURNAL OF PHYSICAL ORGANIC CHEMISTRY

Multifaceted Roles of Alkyltransferase and Related Proteins in DNA Repair, DNA Damage, Resistance to Chemotherapy, and Research Tools

(2011) Anthony E. Pegg   CHEMICAL RESEARCH IN TOXICOLOGY

A phase II study of O6-benzylguanine and temozolomide in pediatric patients with recurrent or progressive high-grade gliomas and brainstem gliomas: a Pediatric Brain Tumor Consortium study

(2011) Katherine E. Warren et al.   JOURNAL OF NEURO-ONCOLOGY

Mechanisms of neurotoxicity induced in the developing brain of mice and rats by DNA-damaging chemicals

(2011) Kunio Doi   JOURNAL OF TOXICOLOGICAL SCIENCES

Selection of genetically modified hematopoietic cells in vitro and in vivo using alkylating agent lysomustine

(2010) F.N. Rozov et al.   ANALYTICAL BIOCHEMISTRY

Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors

(2010) K. O. Hicks et al.   CLINICAL CANCER RESEARCH

DNA interstrand crosslink repair in mammalian cells: step by step

(2009) Parameswary A Muniandy et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Phase II Trial of Temozolomide Plus O6-Benzylguanine in Adults With Recurrent, Temozolomide-Resistant Malignant Glioma

(2009) Jennifer A. Quinn et al.   JOURNAL OF CLINICAL ONCOLOGY

LC−MS/MS for the Detection of DNA Interstrand Cross-Links Formed by 8-Methoxypsoralen and UVA Irradiation in Human Cells

(2008) Huachuan Cao et al.   ANALYTICAL CHEMISTRY

DNA alkylation products formed by 1-(2-chloroethyl)-1-nitrosourea as molecular dosimeters of therapeutic response

(2008) William J. Bodell   JOURNAL OF NEURO-ONCOLOGY