Three-Dimensional Cell Cultures as an In Vitro Tool for Prostate Cancer Modeling and Drug Discovery

Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets

(2020) Fabrizio Fontana et al.   Cells

Mitochondrial functional and structural impairment is involved in the antitumor activity of δ-tocotrienol in prostate cancer cells

(2020) Fabrizio Fontana et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tocotrienols and Cancer: From the State of the Art to Promising Novel Patents

(2019) Fabrizio Fontana et al.   Recent Patents on Anti-Cancer Drug Discovery

Epithelial-To-Mesenchymal Transition Markers and CD44 Isoforms Are Differently Expressed in 2D and 3D Cell Cultures of Prostate Cancer Cells

(2019) Fabrizio Fontana et al.   Cells

δ‐Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells

(2019) Fabrizio Fontana et al.   CELL PROLIFERATION

Treatment of Advanced Prostate Cancer

(2019) Min Yuen Teo et al.   Annual Review of Medicine

Novel lawsone-containing ruthenium(II) complexes: Synthesis, characterization and anticancer activity on 2D and 3D spheroid models of prostate cancer cells

(2019) Rone Aparecido De Grandis et al.   BIOORGANIC CHEMISTRY

Nerve Growth Factor Induces Proliferation and Aggressiveness in Prostate Cancer Cells

(2019) Marzia Di Donato et al.   Cancers

Tumor-derived extracellular vesicles: molecular parcels that enable regulation of the immune response in cancer

(2019) Colin Sheehan et al.   JOURNAL OF CELL SCIENCE

Evaluation of Small Molecule Drug Uptake in Patient-Derived Prostate Cancer Explants by Mass Spectrometry

(2019) Shadrack M. Mutuku et al.   Scientific Reports

Extracellular Vesicles in Cancer Immune Microenvironment and Cancer Immunotherapy

(2019) Feng Xie et al.   Advanced Science

A novel 3D heterotypic spheroid model for studying extracellular vesicle-mediated tumour and immune cell communication

(2018) Lilite Sadovska et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Using high throughput microtissue culture to study the difference in prostate cancer cell behavior and drug response in 2D and 3D co-cultures

(2018) Eman Mosaad et al.   BMC CANCER

ATP Release Channels

(2018) Akiyuki Taruno   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of novel response and predictive biomarkers to Hsp90 inhibitors through mass spectrometry-based proteomic profiling of patient-derived prostate tumor explants

(2018) Elizabeth V Nguyen et al.   MOLECULAR & CELLULAR PROTEOMICS

Targeted AKT Inhibition in Prostate Cancer Cells and Spheroids Reduces Aerobic Glycolysis and Generation of Hyperpolarized [1- 13 C] Lactate

(2018) Sui Seng Tee et al.   MOLECULAR CANCER RESEARCH

The Microwell-mesh: A high-throughput 3D prostate cancer spheroid and drug-testing platform

(2018) E. O. Mosaad et al.   Scientific Reports

Macrophage Cytokines Enhance Cell Proliferation of Normal Prostate Epithelial Cells through Activation of ERK and Akt

(2018) Tu Dang et al.   Scientific Reports

Cancer stem cells: A brief review of current status

(2018) Alican Kuşoğlu et al.   GENE

Anticancer properties of tocotrienols: A review of cellular mechanisms and molecular targets

(2018) Marina Montagnani Marelli et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A patient-derived explant (PDE) model of hormone-dependent cancer

(2018) Margaret M. Centenera et al.   Molecular Oncology

Androgen-targeted therapy in men with prostate cancer: evolving practice and future considerations

(2018) E. David Crawford et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Prostate cancer screening with prostate-specific antigen (PSA) test: a systematic review and meta-analysis

(2018) Dragan Ilic et al.   BMJ-British Medical Journal

Self-Assembling Peptide Gels for 3D Prostate Cancer Spheroid Culture

(2018) Kelly M. Hainline et al.   MACROMOLECULAR BIOSCIENCE

3D growth of cancer cells elicits sensitivity to kinase inhibitors but not lipid metabolism modifiers.

(2018) Dylan Trefor Jones et al.   MOLECULAR CANCER THERAPEUTICS

Applications of Ruthenium Complex in Tumor Diagnosis and Therapy

(2018) Ke Lin et al.   Frontiers in Pharmacology

Folate-targeted amphiphilic cyclodextrin nanoparticles incorporating a fusogenic peptide deliver therapeutic siRNA and inhibit the invasive capacity of 3D prostate cancer tumours

(2017) James C. Evans et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Optimizing structural and mechanical properties of cryogel scaffolds for use in prostate cancer cell culturing

(2017) A. Cecilia et al.   Materials Science & Engineering C-Materials for Biological Applications

Proteasome inhibitors in cancer therapy

(2017) Elisabet E. Manasanch et al.   Nature Reviews Clinical Oncology

Sialylation facilitates self-assembly of 3D multicellular prostaspheres by using cyclo-RGDfK(TPP) peptide

(2017) Sabah Haq et al.   OncoTargets and Therapy

Three‑dimensional cell culture: A powerful tool in tumor research and drug discovery (Review)

(2017) Donglai Lv et al.   Oncology Letters

High-Content Monitoring of Drug Effects in a 3D Spheroid Model

(2017) Frédérique Mittler et al.   Frontiers in Oncology

3D extracellular matrix interactions modulate tumour cell growth, invasion and angiogenesis in engineered tumour microenvironments

(2016) Anna V. Taubenberger et al.   Acta Biomaterialia

Measuring the effects of fractionated radiation therapy in a 3D prostate cancer model system using SERS nanosensors

(2016) Victoria L. Camus et al.   ANALYST

Silk scaffolds connected with different naturally occurring biomaterials for prostate cancer cell cultivation in 3D

(2016) Anne Bäcker et al.   BIOPOLYMERS

Sequential culture on biomimetic nanoclay scaffolds forms three-dimensional tumoroids

(2016) Kalpana S. Katti et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

A systematic review on in vitro 3D bone metastases models: A new horizon to recapitulate the native clinical scenario?

(2016) Francesca Salamanna et al.   Oncotarget

An in vitro 3D bone metastasis model by using a human bone tissue culture and human sex-related cancer cells

(2016) Francesca Salamanna et al.   Oncotarget

3D porous chitosan–alginate scaffolds promote proliferation and enrichment of cancer stem-like cells

(2016) Stephen J. Florczyk et al.   Journal of Materials Chemistry B

New 3D-Culture Approaches to Study Interactions of Bone Marrow Adipocytes with Metastatic Prostate Cancer Cells

(2016) Mackenzie Katheryn Herroon et al.   Frontiers in Endocrinology

3D Porous Chitosan–Alginate Scaffolds as an In Vitro Model for Evaluating Nanoparticle-Mediated Tumor Targeting and Gene Delivery to Prostate Cancer

(2015) Kui Wang et al.   BIOMACROMOLECULES

Core-Cross-Linking Accelerates Antitumor Activities of Paclitaxel–Conjugate Micelles to Prostate Multicellular Tumor Spheroids: A Comparison of 2D and 3D Models

(2015) Alice W. Du et al.   BIOMACROMOLECULES

The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics

(2015) Kathleen A. Fitzgerald et al.   BIOMATERIALS

Controlled 3D culture in Matrigel microbeads to analyze clonal acinar development

(2015) Monika E. Dolega et al.   BIOMATERIALS

Arum Palaestinum with isovanillin, linolenic acid and β-sitosterol inhibits prostate cancer spheroids and reduces the growth rate of prostate tumors in mice

(2015) Caitlin Cole et al.   BMC Complementary and Alternative Medicine

Androgen pathway resistance in prostate cancer and therapeutic implications

(2015) Benjamin L Maughan et al.   EXPERT OPINION ON PHARMACOTHERAPY

Enhancing Accumulation and Penetration of HPMA Copolymer–Doxorubicin Conjugates in 2D and 3D Prostate Cancer Cells via iRGD Conjugation with an MMP-2 Cleavable Spacer

(2015) Zheng-Hong Peng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy

(2015) Colin Rae et al.   RADIATION RESEARCH

Targeting the PI3K/Akt pathway in prostate cancer: Challenges and opportunities (Review)

(2014) PAUL TOREN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Cancer stem cell differentiation: TGFβ1 and versican may trigger molecules for the organization of tumor spheroids

(2014) G. OKTEM et al.   ONCOLOGY REPORTS

3D Cultures of Prostate Cancer Cells Cultured in a Novel High-Throughput Culture Platform Are More Resistant to Chemotherapeutics Compared to Cells Cultured in Monolayer

(2014) Karen F. Chambers et al.   PLoS One

Management of Bone Metastases in Patients with Castration-Resistant Prostate Cancer

(2014) Richard Cathomas et al.   UROLOGIA INTERNATIONALIS

P-glycoprotein Inhibition as a Therapeutic Approach for Overcoming Multidrug Resistance in Cancer: Current Status and Future Perspectives

(2013) Ziyad Binkhathlan et al.   CURRENT CANCER DRUG TARGETS

Pioglitazone and Cancer: Angel or Demon?

(2013) Michael Kostapanos et al.   CURRENT PHARMACEUTICAL DESIGN

Necrosis in DU145 prostate cancer spheroids induces COX-2/mPGES-1-derived PGE2to promote tumor growth and to inhibit T cell activation

(2013) Weixiao Sha et al.   INTERNATIONAL JOURNAL OF CANCER

Ex vivo culture of human prostate tissue and drug development

(2013) Margaret M. Centenera et al.   Nature Reviews Urology

Radiosensitization in prostate cancer: mechanisms and targets

(2013) Diego A Palacios et al.   BMC Urology

Recreating the tumor microenvironment in a bilayer, hyaluronic acid hydrogel construct for the growth of prostate cancer spheroids

(2012) Xian Xu et al.   BIOMATERIALS

Evidence for Efficacy of New Hsp90 Inhibitors Revealed by Ex Vivo Culture of Human Prostate Tumors

(2012) M. M. Centenera et al.   CLINICAL CANCER RESEARCH

Three-dimensional cell culture: the missing link in drug discovery

(2012) Susan Breslin et al.   DRUG DISCOVERY TODAY

Prostate cancer and inflammation: the evidence

(2011) Karen S Sfanos et al.   HISTOPATHOLOGY

Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models

(2011) V Härmä et al.   ONCOGENE

RNA Interference and Cancer Therapy

(2011) Zhaohui Wang et al.   PHARMACEUTICAL RESEARCH

A Simple Hanging Drop Cell Culture Protocol for Generation of 3D Spheroids

(2011) Ramsey Foty   Jove-Journal of Visualized Experiments

Pioglitazone modulates tumor cell metabolism and proliferation in multicellular tumor spheroids

(2010) Eva Gottfried et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A Comprehensive Panel of Three-Dimensional Models for Studies of Prostate Cancer Growth, Invasion and Drug Responses

(2010) Ville Härmä et al.   PLoS One

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Interactions between human osteoblasts and prostate cancer cells in a novel 3D in vitro model

(2010) Shirly Sieh et al.   Organogenesis

Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids

(2009) Amy Y. Hsiao et al.   BIOMATERIALS

Glycolytic pyruvate regulates P-Glycoprotein expression in multicellular tumor spheroids via modulation of the intracellular redox state

(2009) Maria Wartenberg et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The role of doxorubicin and epirubicin in the treatment of patients with metastatic hormone-refractory prostate cancer

(2008) Roberto Petrioli et al.   CANCER TREATMENT REVIEWS

Membrane Type 1 Matrix Metalloproteinase Induces Epithelial-to-Mesenchymal Transition in Prostate Cancer

(2008) Jian Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of a three-dimensional culture model of prostatic epithelial cells and its use for the study of epithelial-mesenchymal transition and inhibition of PI3K pathway in prostate cancer

(2008) Jian Hong Chu et al.   PROSTATE