Exosomes derived from immunogenically dying tumor cells as a versatile tool for vaccination against pancreatic cancer

A Phase 2 Study of Allogeneic GM-CSF Transfected Pancreatic Tumor Vaccine (GVAX) with Ipilimumab as Maintenance Treatment for Metastatic Pancreatic Cancer

(2020) Annie A. Wu et al.   CLINICAL CANCER RESEARCH

Pancreatic cancer-targeting exosomes for enhancing immunotherapy and reprogramming tumor microenvironment

(2020) Wenxi Zhou et al.   BIOMATERIALS

Bone marrow mesenchymal stem cells-derived exosomes for penetrating and targeted chemotherapy of pancreatic cancer

(2019) Yu Zhou et al.   Acta Pharmaceutica Sinica B

Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy

(2018) Xianjun Gao et al.   Science Translational Medicine

Exosomes from M1-Polarized Macrophages Potentiate the Cancer Vaccine by Creating a Pro-inflammatory Microenvironment in the Lymph Node

(2017) Lifang Cheng et al.   MOLECULAR THERAPY

Immunogenic Cell Death Amplified by Co-localized Adjuvant Delivery for Cancer Immunotherapy

(2017) Yuchen Fan et al.   NANO LETTERS

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Lymphatic transport of exosomes as a rapid route of information dissemination to the lymph node

(2016) Swetha Srinivasan et al.   Scientific Reports

Nanovaccine loaded with poly I:C and STAT3 siRNA robustly elicits anti-tumor immune responses through modulating tumor-associated dendritic cells in vivo

(2015) Zichao Luo et al.   BIOMATERIALS

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Exosomes as nanocarriers for immunotherapy of cancer and inflammatory diseases

(2015) Thanh-Huyen Tran et al.   CLINICAL IMMUNOLOGY

The Evolving Role of Immune Checkpoint Inhibitors in Cancer Treatment

(2015) G. K. Pennock et al.   ONCOLOGIST

Have lessons from past failures brought us closer to the success of immunotherapy in metastatic pancreatic cancer?

(2015) Laura Rosa Brunet et al.   OncoImmunology

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

(2014) Charles P. Lai et al.   ACS Nano

Structural basis for ineffective T-cell responses to MHC anchor residue-improved “heteroclitic” peptides

(2014) Florian Madura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dendritic Cell-Derived Exosomes as Immunotherapies in the Fight against Cancer

(2014) J. M. Pitt et al.   JOURNAL OF IMMUNOLOGY

Structure-based programming of lymph-node targeting in molecular vaccines

(2014) Haipeng Liu et al.   NATURE

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Sodium and Cardiovascular Disease

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Pancreatic cancer stroma: Understanding biology leads to new therapeutic strategies

(2014) Agnieszka Anna Rucki   WORLD JOURNAL OF GASTROENTEROLOGY

Two immune faces of pancreatic adenocarcinoma: possible implication for immunotherapy

(2013) Alexandr V. Bazhin et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Inflammatory networks and immune surveillance of pancreatic carcinoma

(2013) Robert H Vonderheide et al.   CURRENT OPINION IN IMMUNOLOGY

The Epidemiology of Pancreatitis and Pancreatic Cancer

(2013) Dhiraj Yadav et al.   GASTROENTEROLOGY

Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans

(2013) D. Sugiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting

(2012) Julia Ekeruche-Makinde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

(2011) A. Montecalvo et al.   BLOOD

Early Detection of Tumor Cells by Innate Immune Cells Leads to Treg Recruitment through CCL22 Production by Tumor Cells

(2011) J. Faget et al.   CANCER RESEARCH

Chemotherapy Delivered After Viral Immunogene Therapy Augments Antitumor Efficacy Via Multiple Immune-mediated Mechanisms

(2010) Zvi G Fridlender et al.   MOLECULAR THERAPY

Melan-A/MART1 Analog Peptide Triggers Anti-myeloma T-cells Through Crossreactivity With HM1.24

(2009) Olaf Christensen et al.   JOURNAL OF IMMUNOTHERAPY