SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

COVID-19 and the cardiovascular system

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A Novel Coronavirus from Patients with Pneumonia in China, 2019

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Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

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Lectin-induced oxidative stress in human platelets

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

(2020) Zhuo Zhou et al.   Cell Host & Microbe

Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes

(2020) Lihua Zhu et al.   Cell Metabolism

COVID-19 as an Acute Inflammatory Disease

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COVID-19: consider cytokine storm syndromes and immunosuppression

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Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

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EV71 virus reduces Nrf2 activation to promote production of reactive oxygen species in infected cells

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Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

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Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment

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Endothelial cell dysfunction: a major player in SARS-CoV-2 infection (COVID-19)?

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Cytokine Storms: Understanding COVID-19

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COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives

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Itraconazole inhibits the Hedgehog signaling pathway thereby inducing autophagy-mediated apoptosis of colon cancer cells

(2020) Huiming Deng et al.   Cell Death & Disease

A parallel-group, multicenter randomized, double-blinded, placebo-controlled, phase 2/3, clinical trial to test the efficacy of pyridostigmine bromide at low doses to reduce mortality or invasive mechanical ventilation in adults with severe SARS-CoV-2 infection: the Pyridostigmine In Severe COvid-19 (PISCO) trial protocol

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A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes

(2020) Tal Noy-Porat et al.   Nature Communications

Statin use is associated with lower disease severity in COVID-19 infection

(2020) Wilnard Y. T. Tan et al.   Scientific Reports

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

(2020) Guangyan Miao et al.   DEVELOPMENTAL CELL

A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection

(2020) Peng Wang et al.   Cell Death & Disease

SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells

(2020) Tapas Patra et al.   PLoS Pathogens

Autophagy induced by avian reovirus enhances viral replication in chickens at the early stage of infection

(2019) Xiaosai Niu et al.   BMC Veterinary Research

Selective cell death of latently HIV-infected CD4+ T cells mediated by autosis inducing nanopeptides

(2019) Gang Zhang et al.   Cell Death & Disease

Effect of Waterlogging-Induced Autophagy on Programmed Cell Death in Arabidopsis Roots

(2019) Bin Guan et al.   Frontiers in Plant Science

Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2

(2019) Pei-Shan Sung et al.   Nature Communications

Antiviral, Antimicrobial and Antibiofilm Activity of Selenoesters and Selenoanhydrides

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Mitochondrial dysfunction in rheumatoid arthritis: A comprehensive analysis by integrating gene expression, protein-protein interactions and gene ontology data

(2019) Venugopal Panga et al.   PLoS One

TNFAIP3-DEPTOR complex regulates inflammasome secretion through autophagy in ankylosing spondylitis monocytes

(2018) Yue Zhai et al.   Autophagy

Autophagy balances inflammation in innate immunity

(2018) Vojo Deretic et al.   Autophagy

Chrysin Attenuates Cell Viability of Human Colorectal Cancer Cells through Autophagy Induction Unlike 5-Fluorouracil/Oxaliplatin

(2018) Yueh-Ming Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Respiratory Syncytial Virus Replication Is Promoted by Autophagy-Mediated Inhibition of Apoptosis

(2018) Miao Li et al.   JOURNAL OF VIROLOGY

Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine

(2018) Rafael Radi   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy protects gastric mucosal epithelial cells from ethanol-induced oxidative damage via mTOR signaling pathway

(2017) Weilong Chang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

(2017) Rudragouda Channappanavar et al.   Seminars in Immunopathology

Studying Autophagy in Zebrafish

(2017) Benan Mathai et al.   Cells

Wild-type rabies virus induces autophagy in human and mouse neuroblastoma cell lines

(2016) Jiaojiao Peng et al.   Autophagy

Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice

(2016) Jihye Han et al.   Autophagy

Eupatilin induces human renal cancer cell apoptosis via ROS-mediated MAPK and PI3K/AKT signaling pathways

(2016) Wei-Feng Zhong et al.   Oncology Letters

Arctigenin Treatment Protects against Brain Damage through an Anti-Inflammatory and Anti-Apoptotic Mechanism after Needle Insertion

(2016) Jie Song et al.   Frontiers in Pharmacology

Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants

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CXCL16 Deficiency Attenuates Renal Injury and Fibrosis in Salt-Sensitive Hypertension

(2016) Hua Liang et al.   Scientific Reports

HPV16 E6 and E7 proteins induce a chronic oxidative stress response via NOX2 that causes genomic instability and increased susceptibility to DNA damage in head and neck cancer cells

(2015) Rossella Marullo et al.   CARCINOGENESIS

ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms

(2015) Lulu Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion

(2015) Paola Maycotte et al.   MOLECULAR CANCER RESEARCH

Coronavirus NSP6 restricts autophagosome expansion

(2014) Eleanor M Cottam et al.   Autophagy

Autophagy and mitochondrial alterations in human retinal pigment epithelial cells induced by ethanol: implications of 4-hydroxy-nonenal

(2014) M Flores-Bellver et al.   Cell Death & Disease

Autophagy and Viruses: Adversaries or Allies?

(2013) Xiaonan Dong et al.   Journal of Innate Immunity

Newcastle disease virus triggers autophagy in U251 glioma cells to enhance virus replication

(2012) Chunchun Meng et al.   ARCHIVES OF VIROLOGY

Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy

(2012) He Huang et al.   Autophagy

Rapamycin Delays Disease Onset and Prevents PrP Plaque Deposition in a Mouse Model of Gerstmann-Straussler-Scheinker Disease

(2012) C. J. Cortes et al.   JOURNAL OF NEUROSCIENCE

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

Regulation of Autophagy by Kinases

(2011) Savitha Sridharan et al.   Cancers

Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway

(2010) Ljubica Vucicevic et al.   Autophagy

Gangliosides induce autophagic cell death in astrocytes

(2010) Jaegyu Hwang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease

(2010) B. R. Underwood et al.   HUMAN MOLECULAR GENETICS

Regulation of innate immune responses by autophagy-related proteins

(2010) Tatsuya Saitoh et al.   JOURNAL OF CELL BIOLOGY

Down-regulation of IL-6, IL-8, TNF-α and IL-1β by glucosamine in HaCaT cells, but not in the presence of TNF-α

(2010) KUN PARK et al.   Oncology Letters

Autophagy proteins promote hepatitis C virus replication

(2009) Marlène Dreux et al.   Autophagy

Autophagy is involved in influenza A virus replication

(2009) Zhi Zhou et al.   Autophagy

Life and death partners: apoptosis, autophagy and the cross-talk between them

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Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes

(2009) Monique Gannagé et al.   Cell Host & Microbe

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL