Inhibition of neutral sphingomyelinase 2 reduces extracellular vesicle release from neurons, oligodendrocytes, and activated microglial cells following acute brain injury

Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson’s disease model

(2021) Dongdong Zhang et al.   Journal of Neuroinflammation

Nipping disease in the bud: nSMase2 inhibitors as therapeutics in extracellular vesicle-mediated diseases

(2021) Carolyn Tallon et al.   DRUG DISCOVERY TODAY

Biophotonics for diagnostic detection of extracellular vesicles

(2021) Alice Gualerzi et al.   ADVANCED DRUG DELIVERY REVIEWS

Src Inhibition Attenuates Neuroinflammation and Protects Dopaminergic Neurons in Parkinson’s Disease Models

(2020) Hanyu Yang et al.   Frontiers in Neuroscience

Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimer’s Disease

(2020) Tina Bilousova et al.   ACS Chemical Biology

Microglial exosomes facilitate α-synuclein transmission in Parkinson’s disease

(2020) Min Guo et al.   BRAIN

The Potent PDE10A Inhibitor MP-10 (PF-2545920) Suppresses Microglial Activation in LPS-Induced Neuroinflammation and MPTP-Induced Parkinson’s Disease Mouse Models

(2020) Do-Yeon Kim et al.   Journal of Neuroimmune Pharmacology

Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival

(2020) Aude Chiot et al.   NATURE NEUROSCIENCE

Microglia and astrocyte dysfunction in parkinson's disease

(2020) Tae-In Kam et al.   NEUROBIOLOGY OF DISEASE

Inhibition of neutral sphingomyelinase 2 promotes remyelination

(2020) Seung-Wan Yoo et al.   Science Advances

An SPRi-based biosensor pilot study: Analysis of multiple circulating extracellular vesicles and hippocampal volume in Alzheimer’s disease

(2020) Silvia Picciolini et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

A novel and potent brain penetrant inhibitor of extracellular vesicle release

(2019) Camilo Rojas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging

(2019) Dimitrios Kapogiannis et al.   JAMA Neurology

Detection and Characterization of Different Brain-Derived Subpopulations of Plasma Exosomes by Surface Plasmon Resonance Imaging

(2018) Silvia Picciolini et al.   ANALYTICAL CHEMISTRY

Inflammation in CNS neurodegenerative diseases

(2018) Jodie Stephenson et al.   IMMUNOLOGY

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles

(2018) Francesc Guix et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biogenesis and function of ESCRT-dependent extracellular vesicles

(2018) Thomas Juan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A System of Cytokines Encapsulated in ExtraCellular Vesicles

(2018) Wendy Fitzgerald et al.   Scientific Reports

Neutral Sphingomyelinase Inhibition Alleviates LPS Induced Microglia Activation and Neuroinflammation after Experimental Traumatic Brain Injury

(2018) Asit Kumar et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation

(2018) Camilo Rojas et al.   Scientific Reports

Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury

(2017) Alok Kumar et al.   Journal of Neuroinflammation

Direct detection of nano-scale extracellular vesicles derived from inflammation-triggered endothelial cells using surface plasmon resonance

(2017) Baharak Hosseinkhani et al.   Nanomedicine-Nanotechnology Biology and Medicine

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research

(2017) Jan Van Deun et al.   NATURE METHODS

Sphingolipids and their metabolism in physiology and disease

(2017) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

(2017) Alex M. Dickens et al.   Science Signaling

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

(2017) Alex M. Dickens et al.   Science Signaling

Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy

(2016) Robert A. Stern et al.   JOURNAL OF ALZHEIMERS DISEASE

Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line

(2016) Maria Podbielska et al.   JOURNAL OF LIPID RESEARCH

Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse

(2016) Michael B. Dinkins et al.   JOURNAL OF NEUROSCIENCE

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Molecular screening of cancer-derived exosomes by surface plasmon resonance spectroscopy

(2015) Luigino Grasso et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies

(2015) Anne Stuendl et al.   BRAIN

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Cambinol, a Novel Inhibitor of Neutral Sphingomyelinase 2 Shows Neuroprotective Properties

(2015) Mariana Figuera-Losada et al.   PLoS One

Brain-derived estrogen exerts anti-inflammatory and neuroprotective actions in the rat hippocampus

(2014) Quan-Guang Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation

(2014) D. Frohlich et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

(2013) Carsten Frühbeis et al.   PLOS BIOLOGY

The spectrum of disease in chronic traumatic encephalopathy

(2012) Ann C. McKee et al.   BRAIN

The Roles of Neutral Sphingomyelinases in Neurological Pathologies

(2012) Charles R. Horres et al.   NEUROCHEMICAL RESEARCH

The systemic response to brain injury and disease

(2011) Daniel C. Anthony et al.   BRAIN BEHAVIOR AND IMMUNITY

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

(2011) Bence György et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

Effects of ropivacaine on adhesion molecule CD11b expression and function in human neutrophils

(2010) Xuqin Zhu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of Myelin Membrane Sheath Formation by Oligodendrocyte-derived Exosome-like Vesicles

(2010) Mostafa Bakhti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory responses in the rat brain in response to different methods of intra-cerebral administration

(2008) Lisa McCluskey et al.   JOURNAL OF NEUROIMMUNOLOGY

Regulation of Neutral Sphingomyelinase-2 (nSMase2) by Tumor Necrosis Factor-  Involves Protein Kinase C-  in Lung Epithelial Cells

(2008) C. J. Clarke et al.   MOLECULAR PHARMACOLOGY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE