Nipping disease in the bud: nSMase2 inhibitors as therapeutics in extracellular vesicle-mediated diseases

Small Molecule Inhibitors Targeting Biosynthesis of Ceramide, the Central Hub of the Sphingolipid Network

(2021) Jan Skácel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glutaminase 1 Regulates Neuroinflammation After Cerebral Ischemia Through Enhancing Microglial Activation and Pro-Inflammatory Exosome Release

(2020) Ge Gao et al.   Frontiers in Immunology

Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimer’s Disease

(2020) Tina Bilousova et al.   ACS Chemical Biology

A longitudinal study on α‐synuclein in plasma neuronal exosomes as a biomarker for Parkinson’s disease development and progression

(2020) M. Niu et al.   EUROPEAN JOURNAL OF NEUROLOGY

Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer’s Disease

(2020) Michal Šála et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploring Sphingolipid Implications in Neurodegeneration

(2020) Alice V. Alessenko et al.   Frontiers in Neurology

Exosomes released from Shiga toxin 2a‐treated human macrophages modulate inflammatory responses and induce cell death in toxin receptor expressing human cells

(2020) Kyung‐Soo Lee et al.   CELLULAR MICROBIOLOGY

Human Cytomegalovirus Utilizes Extracellular Vesicles To Enhance Virus Spread

(2020) Nicholas T. Streck et al.   JOURNAL OF VIROLOGY

Small-Medium Extracellular Vesicles and Their miRNA Cargo in Retinal Health and Degeneration: Mediators of Homeostasis, and Vehicles for Targeted Gene Therapy

(2020) Yvette Wooff et al.   Frontiers in Cellular Neuroscience

Extracellular Vesicles in the Pathogenesis of Viral Infections in Humans

(2020) Allen Caobi et al.   Viruses-Basel

Inhibition of neutral sphingomyelinase 2 promotes remyelination

(2020) Seung-Wan Yoo et al.   Science Advances

Methods for Separation and Characterization of Extracellular Vesicles: Results of a Worldwide Survey Performed by the ISEV Rigor and Standardization Subcommittee

(2020) Felix Royo et al.   Cells

The nSMase2/Smpd3 gene modulates the severity of muscular dystrophy and the emotional stress response in mdx mice

(2020) Yasunari Matsuzaka et al.   BMC Medicine

Exosomes Released from Rabies Virus-Infected Cells May be Involved in the Infection Process

(2019) Jingyu Wang et al.   VIROLOGICA SINICA

Exosomes mediate Zika virus transmission through SMPD3 neutral Sphingomyelinase in cortical neurons

(2019) Wenshuo Zhou et al.   Emerging Microbes & Infections

Extracellular Vesicles from Mesenchymal Stem Cells Exert Pleiotropic Effects on Amyloid‐β, Inflammation, and Regeneration: A Spark of Hope for Alzheimer's Disease from Tiny Structures?

(2019) Chiara A. Elia et al.   BIOESSAYS

Small hairpin RNA and pharmacological targeting of neutral sphingomyelinase prevents diaphragm weakness in rats with heart failure and reduced ejection fraction

(2019) Philip D. Coblentz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Involvement of exosomes in dopaminergic neurodegeneration by microglial activation in midbrain slice cultures

(2019) Reiho Tsutsumi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold

(2019) Ondrej Stepanek et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Snail1-dependent cancer-associated fibroblasts induce epithelial-mesenchymal transition in lung cancer cells via exosomes

(2019) J You et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

A novel and potent brain penetrant inhibitor of extracellular vesicle release

(2019) Camilo Rojas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging

(2019) Dimitrios Kapogiannis et al.   JAMA Neurology

Exosomal transfer of miR-501 confers doxorubicin resistance and tumorigenesis via targeting of BLID in gastric cancer

(2019) Xu Liu et al.   CANCER LETTERS

The multiple roles of exosomes in Parkinson's disease: an overview

(2019) Chiara Porro et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Inhibition of nSMase2 Reduces the Transfer of Oligomeric α-Synuclein Irrespective of Hypoxia

(2019) Valerie Sackmann et al.   Frontiers in Molecular Neuroscience

Extracellular vesicles or exosomes? On primacy, precision, and popularity influencing a choice of nomenclature

(2019) Kenneth W. Witwer et al.   Journal of Extracellular Vesicles

Syntaxin 6‐mediated exosome secretion regulates enzalutamide resistance in prostate cancer

(2019) Taylor C. Peak et al.   MOLECULAR CARCINOGENESIS

Exosomes Derived From M2b Macrophages Attenuate DSS-Induced Colitis

(2019) Ruibing Yang et al.   Frontiers in Immunology

Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop

(2019) Ashley E. Russell et al.   Journal of Extracellular Vesicles

Amitriptyline inhibits nonalcoholic steatohepatitis and atherosclerosis induced by high-fat diet and LPS through modulation of sphingolipid metabolism

(2019) Zhongyang Lu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing

(2019) Yang You et al.   Journal of Extracellular Vesicles

Extracellular Vesicles From Pathological Microenvironment Induce Endothelial Cell Transformation and Abnormal Angiogenesis via Modulation of TRPV4 Channels

(2019) Brianna D. Guarino et al.   Frontiers in Cell and Developmental Biology

nSMase2 (Type 2-Neutral Sphingomyelinase) Deficiency or Inhibition by GW4869 Reduces Inflammation and Atherosclerosis in Apoe−/−MiceHighlights

(2018) Tom Lallemand et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2

(2018) Tina Bilousova et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth

(2018) Yi Yang et al.   CELL RESEARCH

Secretion of Hepatitis C Virus Replication Intermediates Reduces Activation of Toll-Like Receptor 3 in Hepatocytes

(2018) Oliver Grünvogel et al.   GASTROENTEROLOGY

Mifepristone Inhibits the Migration of Cervical Cancer Cells by Inhibiting Exocrine Secretion

(2018) Lin Sang et al.   PHARMACOLOGY

Arthropod EVs mediate dengue virus transmission through interaction with a tetraspanin domain containing glycoprotein Tsp29Fb

(2018) Ashish Vora et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of sphingolipid metabolism disruption on lipopolysaccharide-induced lung injury in mice

(2018) Renata Tiemi Okuro et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Tumor-associated macrophages-derived exosomes promote the migration of gastric cancer cells by transfer of functional Apolipoprotein E

(2018) Peiming Zheng et al.   Cell Death & Disease

Exosomes serve as novel modes of tick-borne flavivirus transmission from arthropod to human cells and facilitates dissemination of viral RNA and proteins to the vertebrate neuronal cells

(2018) Wenshuo Zhou et al.   PLoS Pathogens

Zika virus propagation and release in human fetal astrocytes can be suppressed by neutral sphingomyelinase-2 inhibitor GW4869

(2018) Yunlong Huang et al.   Cell Discovery

Brain microvascular endothelial cell exosome–mediated S100A16 up-regulation confers small-cell lung cancer cell survival in brain

(2018) Zhi-Hua Xu et al.   FASEB JOURNAL

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Detection of viral components in exosomes derived from NDV-infected DF-1 cells and their promoting ability in virus replication

(2018) Xiaohong Xu et al.   MICROBIAL PATHOGENESIS

Exosomes play a role in multiple myeloma bone disease and tumor development by targeting osteoclasts and osteoblasts

(2018) Sylvia Faict et al.   Blood Cancer Journal

DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation

(2018) Camilo Rojas et al.   Scientific Reports

Exosomes Derived From Pancreatic Stellate Cells

(2017) Tetsuya Takikawa et al.   PANCREAS

Nanosized UCMSC-derived extracellular vesicles but not conditioned medium exclusively inhibit the inflammatory response of stimulated T cells: implications for nanomedicine

(2017) Marta Monguió-Tortajada et al.   Theranostics

Protein and chemotherapy profiling of extracellular vesicles harvested from therapeutic induced senescent triple negative breast cancer cells

(2017) E L Kavanagh et al.   Oncogenesis

Oligomer formation of Clostridium perfringens epsilon-toxin is induced by activation of neutral sphingomyelinase

(2016) Teruhisa Takagishi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Exosome secretion is a key pathway for clearance of pathological TDP-43

(2016) Yohei Iguchi et al.   BRAIN

Inhibitors of the sphingomyelin cycle: Sphingomyelin synthases and sphingomyelinases

(2016) Mohamad Adada et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Stimulating the Release of Exosomes Increases the Intercellular Transfer of Prions

(2016) Belinda B. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes derived from mature dendritic cells increase endothelial inflammation and atherosclerosisviamembrane TNF-α mediated NF-κB pathway

(2016) Wei Gao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse

(2016) Michael B. Dinkins et al.   JOURNAL OF NEUROSCIENCE

Extracellular vesicles in neurodegenerative disease — pathogenesis to biomarkers

(2016) Alexander G. Thompson et al.   Nature Reviews Neurology

Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells

(2016) K E Richards et al.   ONCOGENE

Neutral sphingomyelinase 2 is required for cytokine-induced skeletal muscle calpain activation

(2015) Gerald S. Supinski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction

(2015) Kobina Essandoh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Efficient inhibition of infectious prions multiplication and release by targeting the exosomal pathway

(2015) Didier Vilette et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Guggulsterone and bexarotene induce secretion of exosome-associated breast cancer resistance protein and reduce doxorubicin resistance in MDA-MB-231 cells

(2015) Ji Na Kong et al.   INTERNATIONAL JOURNAL OF CANCER

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Cambinol, a Novel Inhibitor of Neutral Sphingomyelinase 2 Shows Neuroprotective Properties

(2015) Mariana Figuera-Losada et al.   PLoS One

The Neutral Sphingomyelinase Pathway Regulates Packaging of the Prion Protein into Exosomes

(2014) Belinda B. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies

(2014) S. Nagashima et al.   JOURNAL OF GENERAL VIROLOGY

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Exosome-mediated extracellular release of polyadenylate-binding protein 1 in human metastatic duodenal cancer cells

(2014) Keiichi Ohshima et al.   PROTEOMICS

Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

(2014) Rania Ghossoub et al.   Nature Communications

Proinflammatory role of epithelial cell–derived exosomes in allergic airway inflammation

(2013) Ankur Kulshreshtha et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi

(2013) LiZe Gu et al.   Journal of Neuroinflammation

γ-Synuclein: Seeding of α-Synuclein Aggregation and Transmission between Cells

(2012) Irina Surgucheva et al.   BIOCHEMISTRY

Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy

(2012) Y. Lee et al.   HUMAN MOLECULAR GENETICS

Endothelin-1 Stimulates Small Artery VCAM-1 Expression through p38MAPK-Dependent Neutral Sphingomyelinase

(2012) Jacqueline Ohanian et al.   JOURNAL OF VASCULAR RESEARCH

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

Identification and Characterization of Murine Mitochondria-associated Neutral Sphingomyelinase (MA-nSMase), the Mammalian Sphingomyelin Phosphodiesterase 5

(2010) Bill X. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Neutral Sphingomyelinases: Regulation and Roles in Cell Signaling Responses

(2010) Bill X. Wu et al.   NEUROMOLECULAR MEDICINE

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE