Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages
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Title
Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages
Authors
Keywords
Chalcones, 15-lipoxygenase, Lipid mediators, Specialized pro-resolving mediators, Macrophages, Inflammation resolution
Journal
BIOCHEMICAL PHARMACOLOGY
Volume 195, Issue -, Pages 114825
Publisher
Elsevier BV
Online
2021-11-08
DOI
10.1016/j.bcp.2021.114825
References
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- (2019) Ryan G. Snodgrass et al. Frontiers in Pharmacology
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- (2017) Robert A. Whittington et al. Frontiers in Immunology
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- Small molecules with anti-inflammatory properties in clinical development
- (2016) Thomas Hanke et al. PHARMACOLOGY & THERAPEUTICS
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- (2015) Hamid Sadeghian et al. EXPERT OPINION ON THERAPEUTIC PATENTS
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- (2015) Igor Ivanov et al. GENE
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- Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation
- (2014) Christopher D. Buckley et al. IMMUNITY
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- (2014) Charles N. Serhan NATURE
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- (2012) J. Dalli et al. BLOOD
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- (2008) C. Kontogiorgis et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
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