Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages

Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators

(2021) Simona Pace et al.   PHARMACOLOGICAL RESEARCH

From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution

(2021) Tran Thi Van Anh et al.   Acta Pharmaceutica Sinica B

Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products

(2020) Nathaniel C. Gilbert et al.   Nature Chemical Biology

Encapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity

(2020) Blerina Shkodra-Pula et al.   JOURNAL OF NANOBIOTECHNOLOGY

Screening of chalcone analogs with anti-depressant, anti-inflammatory, analgesic, and COX-2-inhibiting effects

(2020) Zhe-Hao Huang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chalcones bearing a 3,4,5-trimethoxyphenyl motif are capable of selectively inhibiting oncogenic K-Ras signaling

(2020) Sarah E. Kovar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dual Inhibitory Action of a Novel AKR1C3 Inhibitor on Both Full-Length AR and the Variant AR-V7 in Enzalutamide Resistant Metastatic Castration Resistant Prostate Cancer

(2020) Mona Kafka et al.   Cancers

Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction

(2020) Fabian Mayr et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution

(2020) Paul M. Jordan et al.   Cell Reports

Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome

(2019) Markus Werner et al.   FASEB JOURNAL

Regulation and Functions of 15-Lipoxygenases in Human Macrophages

(2019) Ryan G. Snodgrass et al.   Frontiers in Pharmacology

Ginkgolic Acid is a Multi-Target Inhibitor of Key Enzymes in Pro-Inflammatory Lipid Mediator Biosynthesis

(2019) Jana Gerstmeier et al.   Frontiers in Pharmacology

Chalcone-Thiazole Hybrids: Rational Design, Synthesis, and Lead Identification against 5-Lipoxygenase

(2019) Shweta Sinha et al.   ACS Medicinal Chemistry Letters

Click chemistry synthesis, biological evaluation and docking study of some novel 2′-hydroxychalcone-triazole hybrids as potent anti-inflammatory agents

(2019) Andrew N. Boshra et al.   BIOORGANIC CHEMISTRY

Specialized pro-resolving lipid mediators: A new class of non-immunosuppressive and non-opioid analgesic drugs

(2019) Victor Fattori et al.   PHARMACOLOGICAL RESEARCH

Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology

(2018) Jesmond Dalli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

(2018) Oliver Werz et al.   Nature Communications

Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation

(2018) Sun-Yee Cheung et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Does promoting resolution instead of inhibiting inflammation represent the new paradigm in treating infections?

(2017) Jesmond Dalli   MOLECULAR ASPECTS OF MEDICINE

Impaired Resolution of Inflammation in Alzheimer’s Disease: A Review

(2017) Robert A. Whittington et al.   Frontiers in Immunology

Humudifucol and Bioactive Prenylated Polyphenols from Hops (Humulus lupulus cv. “Cascade”)

(2016) Martino Forino et al.   JOURNAL OF NATURAL PRODUCTS

Small molecules with anti-inflammatory properties in clinical development

(2016) Thomas Hanke et al.   PHARMACOLOGY & THERAPEUTICS

15-Lipoxygenase inhibitors: a patent review

(2015) Hamid Sadeghian et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)

(2015) Igor Ivanov et al.   GENE

An experimental cell-based model for studying the cell biology and molecular pharmacology of 5-lipoxygenase-activating protein in leukotriene biosynthesis

(2014) Jana Gerstmeier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

Dynamic eicosanoid responses upon different inhibitor and combination treatments on the arachidonic acid metabolic network

(2012) Chong He et al.   Molecular BioSystems

Two New C-benzylated Dihydrochalcone Derivatives from the Leaves of Melodorum siamensis

(2012) Uma Prawat et al.   PLANTA MEDICA

Recent progress in therapeutic applications of chalcones

(2011) Anna-Maria Katsori et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Design, synthesis, and biological evaluation of prenylated chalcones as 5-LOX inhibitors

(2010) Nimmanapalli P. Reddy et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Anti-inflammatory Agents: Present and Future

(2010) Charles A. Dinarello   CELL

Inflammation 2010: New Adventures of an Old Flame

(2010) Ruslan Medzhitov   CELL

Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors

(2008) Amol Gupte et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chalcones and their Potential Role in Inflammation

(2008) C. Kontogiorgis et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY