Antidepressant actions of melatonin and melatonin receptor agonist: Focus on pathophysiology and treatment
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Antidepressant actions of melatonin and melatonin receptor agonist: Focus on pathophysiology and treatment
Authors
Keywords
Depression, Melatonin, Agomelatine, Ramelteon, Antidepressant, Pathophysiology
Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 420, Issue -, Pages 113724
Publisher
Elsevier BV
Online
2021-12-18
DOI
10.1016/j.bbr.2021.113724
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Melatonin modulates copper-induced anxiety-like, depression-like and memory impairments by acting on hippocampal oxidative stress in rat
- (2021) Mouloud Lamtai et al. DRUG AND CHEMICAL TOXICOLOGY
- GW117: A novel serotonin (5‐HT 2C ) receptor antagonist and melatonin (MT 1 /MT 2 ) receptor agonist with potential antidepressant‐like activity in rodents
- (2021) Nana Gao et al. CNS Neuroscience & Therapeutics
- On inflammatory hypothesis of depression: what is the role of IL-6 in the middle of the chaos?
- (2021) Elnaz Roohi et al. Journal of Neuroinflammation
- Update on GPCR-based targets for the development of novel antidepressants
- (2021) Ioannis Mantas et al. MOLECULAR PSYCHIATRY
- The receptor hypothesis and the pathogenesis of depression: genetic bases and biological correlates
- (2021) Hui-Qin Wang et al. PHARMACOLOGICAL RESEARCH
- Chronic Piromelatine Treatment Alleviates Anxiety, Depressive Responses and Abnormal Hypothalamic–Pituitary–Adrenal Axis Activity in Prenatally Stressed Male and Female Rats
- (2021) Natasha Ivanova et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Molecular Regulation of the Melatonin Biosynthesis Pathway in Unipolar and Bipolar Depression
- (2021) Monika Dmitrzak-Weglarz et al. Frontiers in Pharmacology
- Melatonin and Depression: A Translational Perspective From Animal Models to Clinical Studies
- (2021) André C. Tonon et al. Frontiers in Psychiatry
- Evaluation of salivary melatonin concentrations as a circadian phase maker of morning awakening and their association with depressive mood in postpartum mothers
- (2021) Naoko Kudo et al. CHRONOBIOLOGY INTERNATIONAL
- Melatonin and Sleep Disturbances in Alzheimer’s Disease
- (2021) A. H. M. Safayet Ullah Prodhan et al. CNS & Neurological Disorders-Drug Targets
- Tasimelteon safely and effectively improves sleep in Smith–Magenis syndrome: a double-blind randomized trial followed by an open-label extension
- (2021) Christos M. Polymeropoulos et al. GENETICS IN MEDICINE
- Neurogenic hypothesis of positive psychology in stress-induced depression: Adult hippocampal neurogenesis, neuroinflammation, and stress resilience
- (2021) Zuotian Wu et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Low Doses of Ketamine and Melatonin in Combination Produce Additive Antidepressant-like Effects in Mice
- (2021) Rosa Estrada-Reyes et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction
- (2021) David M Thomson et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Paeoniflorin: A neuroprotective monoterpenoid glycoside with promising anti-depressive properties
- (2021) Xiao-Le Wang et al. PHYTOMEDICINE
- Prenatal maternal posttraumatic stress disorder as a risk factor for adverse birth weight and gestational age outcomes: A systematic review and meta-analysis
- (2021) Pilar M. Sanjuan et al. JOURNAL OF AFFECTIVE DISORDERS
- Reduced neuroinflammation and enhanced neurogenesis following chronic agomelatine treatment in rats undergoing chronic constant light
- (2021) Dimitrinka Atanasova et al. NEUROPHARMACOLOGY
- Translational evidence for the Inflammatory Response System (IRS)/Compensatory Immune Response System (CIRS) and neuroprogression theory of major depression
- (2021) Monojit Debnath et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Melatonin Modulates Dendrite Maturation and Complexity in the Dorsal- and Ventral- Dentate Gyrus Concomitantly with Its Antidepressant-Like Effect in Male Balb/C Mice
- (2020) Gerardo Bernabé Ramírez-Rodríguez et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Saliva cortisol, melatonin levels and circadian rhythm alterations in Chinese primary school children with dyslexia
- (2020) Yanhong Huang et al. MEDICINE
- Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation
- (2020) Tahir Ali et al. JOURNAL OF PINEAL RESEARCH
- Melatonin Reverses the Depression-associated Behaviour and Regulates Microglia, Fractalkine Expression and Neurogenesis in Adult Mice Exposed to Chronic Mild Stress
- (2020) Nelly Maritza Vega-Rivera et al. NEUROSCIENCE
- Blue Light Deprivation Produces Depression-Like Responses in Mongolian Gerbils
- (2020) Hong Hu et al. Frontiers in Psychiatry
- Melatonin Act as an Antidepressant via Attenuation of Neuroinflammation by Targeting Sirt1/Nrf2/HO-1 Signaling
- (2020) Tahir Ali et al. Frontiers in Molecular Neuroscience
- The Changes of Expression and Methylation of Genes Involved in Oxidative Stress in Course of Chronic Mild Stress and Antidepressant Therapy with Agomelatine
- (2020) Paulina Wigner et al. Genes
- Effect of 5-HT2C receptor agonist and antagonist on chronic unpredictable stress (CUS) - Mediated anxiety and depression in adolescent Wistar albino rat: Implicating serotonin and mitochondrial ETC-I function in serotonergic neurotransmission
- (2020) Wankupar Wankhar et al. BEHAVIOURAL BRAIN RESEARCH
- EA Ameliorated Depressive Behaviors in CUMS Rats and Was Related to Its Suppressing Autophagy in the Hippocampus
- (2020) Zhinan Zhang et al. NEURAL PLASTICITY
- Pharmacological evaluation of NO/cGMP/KATP channels pathway in the antidepressant-like effect of carbamazepine in mice
- (2020) Mostafa Ajaman et al. BEHAVIOURAL PHARMACOLOGY
- Circadian photoperiod alters TREK‐1 channel function and expression in dorsal raphe serotonergic neurons via melatonin receptor 1 signaling
- (2020) Manuel A. Giannoni‐Guzmán et al. JOURNAL OF PINEAL RESEARCH
- Sub-Acute Oral Toxicity of a Novel Derivative of Agomelatine in Rats in a Sex-Dependent Manner
- (2019) Qiushi Yang et al. Frontiers in Pharmacology
- Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic stress-induced depression
- (2019) Bojana Stefanovic et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Melatonergic agonist regulates circadian clock genes and peripheral inflammatory and neuroplasticity markers in patients with depression and anxiety
- (2019) Senthil Kumaran Satyanarayanan et al. BRAIN BEHAVIOR AND IMMUNITY
- Venlafaxine plus melatonin ameliorate reserpine-induced depression-like behavior in zebrafish
- (2019) Ya-Qiu Tang et al. NEUROTOXICOLOGY AND TERATOLOGY
- Systematic review and meta-analysis of the relationship between sleep disorders and suicidal behaviour in patients with depression
- (2019) Xiaofen Wang et al. BMC Psychiatry
- The Knockdown of TREK-1 in Hippocampal Neurons Attenuate Lipopolysaccharide-Induced Depressive-Like Behavior in Mice
- (2019) Ajung Kim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Daytime melatonin levels in saliva are associated with inflammatory markers and anxiety disorders
- (2019) Isak Sundberg et al. PSYCHONEUROENDOCRINOLOGY
- Neurobiology and consequences of social isolation stress in animal model—A comprehensive review
- (2018) Faiza Mumtaz et al. BIOMEDICINE & PHARMACOTHERAPY
- Effect of agomelatine 25–50 mg on functional outcomes in patients with major depressive disorder
- (2018) Sidney H. Kennedy et al. JOURNAL OF AFFECTIVE DISORDERS
- A congenic line of the C57BL/6J mouse strain that is proficient in melatonin synthesis
- (2018) Zhijing Zhang et al. JOURNAL OF PINEAL RESEARCH
- Expression and immunolocalization of metallothioneins MT1, MT2 and MT3 in rat nephron
- (2018) Ivan Sabolić et al. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
- Anti-Oxidative Effects of Melatonin Receptor Agonist and Omega-3 Polyunsaturated Fatty Acids in Neuronal SH-SY5Y Cells: Deciphering Synergic Effects on Anti-Depressant Mechanisms
- (2018) Senthil Kumaran Satyanarayanan et al. MOLECULAR NEUROBIOLOGY
- Agomelatine treatment corrects symptoms of depression and anxiety by restoring the disrupted melatonin circadian rhythms of rats exposed to chronic constant light
- (2018) Jana Tchekalarova et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Neuroprotective effect of melatonin against lipopolysaccharide-induced depressive-like behavior in mice
- (2018) E.H. Taniguti et al. PHYSIOLOGY & BEHAVIOR
- 0986 Tasimelteon Improves Symptoms of Major Depression in an African American Population
- (2018) M Polymeropoulos et al. SLEEP
- 0986 Tasimelteon Improves Symptoms of Major Depression in an African American Population
- (2018) M Polymeropoulos et al. SLEEP
- Circadian rhythm and melatonin in the treatment of depression
- (2018) Senthil Kumaran Satyanarayanan et al. CURRENT PHARMACEUTICAL DESIGN
- The Timing of Melatonin Administration Is Crucial for Its Antidepressant-Like Effect in Mice
- (2018) Rosa Estrada-Reyes et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Agomelatine-induced modulation of brain-derived neurotrophic factor (BDNF) in the rat hippocampus
- (2018) Yanxia Lu et al. LIFE SCIENCES
- Depression
- (2018) Gin S Malhi et al. LANCET
- Melatonin produces a rapid onset and prolonged efficacy in reducing depression-like behaviors in adult rats exposed to chronic unpredictable mild stress
- (2017) Xiaoran Sun et al. NEUROSCIENCE LETTERS
- Monoaminergic neuropathology in Alzheimer’s disease
- (2017) Goran Šimić et al. PROGRESS IN NEUROBIOLOGY
- Chronotype and circadian rhythm in bipolar disorder: A systematic review
- (2017) Matias C.A. Melo et al. SLEEP MEDICINE REVIEWS
- Targeting Free Radicals in Oxidative Stress-Related Human Diseases
- (2017) Patrik Poprac et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- The effect of MElatonin on Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome (MEDACIS): study protocol for a randomized controlled trial
- (2017) Michael Tvilling Madsen et al. Trials
- Melatonin Augments the Effects of Fluoxetine on Depression-Like Behavior and Hippocampal BDNF–TrkB Signaling
- (2017) Kun Li et al. Neuroscience Bulletin
- MT1and MT2Melatonin Receptors: A Therapeutic Perspective
- (2016) Jiabei Liu et al. Annual Review of Pharmacology and Toxicology
- Consequences of long-term treatment with agomelatine on depressive-like behavior and neurobiological abnormalities in pinealectomized rats
- (2016) Jana Tchekalarova et al. BEHAVIOURAL BRAIN RESEARCH
- Differential melatonin alterations in cerebrospinal fluid and serum of patients with major depressive disorder and bipolar disorder
- (2016) J.M. Bumb et al. COMPREHENSIVE PSYCHIATRY
- Melatonin mediated antidepressant-like effect in the hippocampus of chronic stress-induced depression rats: Regulating vesicular monoamine transporter 2 and monoamine oxidase A levels
- (2016) Bojana Stefanovic et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Sustained efficacy of agomelatine 10 mg, 25 mg, and 25–50 mg on depressive symptoms and functional outcomes in patients with major depressive disorder. A placebo-controlled study over 6 months
- (2016) Sidney H. Kennedy et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Agomelatine reduces brain, kidney and liver oxidative stress but increases plasma cytokine production in the rats with chronic mild stress-induced depression
- (2016) Arif Demirdaş et al. METABOLIC BRAIN DISEASE
- HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition
- (2016) J Keller et al. MOLECULAR PSYCHIATRY
- Melatonin and neurotrophins NT-3, BDNF, NGF in patients with varying levels of depression severity
- (2016) Ewa A. Ogłodek et al. Pharmacological Reports
- Salivary Melatonin in Relation to Depressive Symptom Severity in Young Adults
- (2016) Isak Sundberg et al. PLoS One
- Piromelatine ameliorates memory deficits associated with chronic mild stress-induced anhedonia in rats
- (2016) Wan Fu et al. PSYCHOPHARMACOLOGY
- Melancholic-Like Behaviors and Circadian Neurobiological Abnormalities in Melatonin MT1 Receptor Knockout Mice
- (2015) S. Comai et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Neuronal DNA Methylation Profiling of Blast-Related Traumatic Brain Injury
- (2015) Fatemeh Haghighi et al. JOURNAL OF NEUROTRAUMA
- Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis
- (2015) Anna Fernández et al. JOURNAL OF PINEAL RESEARCH
- Changes in cognitive symptoms after a buspirone–melatonin combination treatment for Major Depressive Disorder
- (2015) Steven D. Targum et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder
- (2015) A. K. Wittenborn et al. PSYCHOLOGICAL MEDICINE
- Effect of melatonin on depressive symptoms and anxiety in patients undergoing breast cancer surgery: a randomized, double-blind, placebo-controlled trial
- (2014) Melissa V. Hansen et al. BREAST CANCER RESEARCH AND TREATMENT
- Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder
- (2014) Andras David Nagy et al. CHRONOBIOLOGY INTERNATIONAL
- Piromelatine, a novel melatonin receptor agonist, stabilizes metabolic profiles and ameliorates insulin resistance in chronic sleep restricted rats
- (2014) Meihua She et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology
- (2014) Stefano Comai et al. JOURNAL OF PSYCHIATRY & NEUROSCIENCE
- Ramelteon for the treatment of insomnia in adults: a systematic review and meta-analysis
- (2014) Akira Kuriyama et al. SLEEP MEDICINE
- ASMT gene expression correlates with cognitive impairment in patients with recurrent depressive disorder
- (2014) Piotr Gałecki MEDICAL SCIENCE MONITOR
- Anxiety and depression following preeclampsia or hemolysis, elevated liver enzymes, and low platelets syndrome. A systematic review
- (2013) Denise H.J. Delahaije et al. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
- Encoding and Transducing the Synaptic or Extrasynaptic Origin of NMDA Receptor Signals to the Nucleus
- (2013) Anna Karpova et al. CELL
- Agomelatine in depression
- (2013) Enrico Smeraldi et al. Expert Opinion On Drug Safety
- The Efficacy of Agomelatine in Elderly Patients With Recurrent Major Depressive Disorder
- (2013) Reinhard Heun et al. JOURNAL OF CLINICAL PSYCHIATRY
- Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder
- (2012) Bruno Etain et al. HUMAN MOLECULAR GENETICS
- Melatonin potentiates running wheel-induced neurogenesis in the dentate gyrus of adult C3H/HeN mice hippocampus
- (2012) Jiabei Liu et al. JOURNAL OF PINEAL RESEARCH
- Anxiolytic effects of the melatonin MT2 receptor partial agonist UCM765: Comparison with melatonin and diazepam
- (2012) Rafael Ochoa-Sanchez et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Augmentation with ramelteon to achieve remission in geriatric major depression
- (2012) Motohide Furuya et al. PSYCHIATRY AND CLINICAL NEUROSCIENCES
- The Emerging Role of Melatonin Agonists in the Treatment of Major Depression: Focus on Agomelatine
- (2011) Domenico De Berardis et al. CNS & Neurological Disorders-Drug Targets
- The size and burden of mental disorders and other disorders of the brain in Europe 2010
- (2011) H.U. Wittchen et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Novel melatonin-based therapies: potential advances in the treatment of major depression
- (2011) Ian B Hickie et al. LANCET
- Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: A 24-week follow-up study
- (2011) Vahap Ozan Kotan et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Single nucleotide polymorphisms and mRNA expression for melatonin MT2 receptor in depression
- (2011) Elżbieta Gałecka et al. PSYCHIATRY RESEARCH
- Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC
- (2011) Nataly Ladurelle et al. PSYCHOPHARMACOLOGY
- Antidepressant- and anxiolytic effects of the novel melatonin agonist Neu-P11 in rodent models
- (2010) Shao-wen Tian et al. ACTA PHARMACOLOGICA SINICA
- Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs
- (2010) Venkatramanujam Srinivasan et al. ADVANCES IN THERAPY
- Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder
- (2010) Piotr Gałecki et al. JOURNAL OF PINEAL RESEARCH
- Antidepressant-like effects of melatonin in the mouse chronic mild stress model
- (2009) Bernardo C. Detanico et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- A pilot study of the phase angle between cortisol and melatonin in major depression – A potential biomarker?
- (2009) Theresa M. Buckley et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Pathophysiology of depression: Role of sleep and the melatonergic system
- (2009) Venkataramanujan Srinivasan et al. PSYCHIATRY RESEARCH
- Melatonin formation in mammals: In vivo perspectives
- (2009) Asamanja Chattoraj et al. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
- Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome
- (2009) Shadab A. Rahman et al. SLEEP MEDICINE
- Ramelteon: A Novel Approach in the Treatment of Insomnia
- (2008) Jill N Reynoldson et al. ANNALS OF PHARMACOTHERAPY
- Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials
- (2008) Shantha MW Rajaratnam et al. LANCET
- Stimulatory effects of a melatonin receptor agonist, ramelteon, on BDNF in mouse cerebellar granule cells
- (2008) Marta Imbesi et al. NEUROSCIENCE LETTERS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started