Melatonin and Depression: A Translational Perspective From Animal Models to Clinical Studies

Immune‐pineal axis protects rat lungs exposed to polluted air

(2020) Claudia Emanuele Carvalho‐Sousa et al.   JOURNAL OF PINEAL RESEARCH

Practice guideline: Treatment for insomnia and disrupted sleep behavior in children and adolescents with autism spectrum disorder

(2020) Ashura Williams Buckley et al.   NEUROLOGY

Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation

(2020) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

Melatonin Reverses the Depression-associated Behaviour and Regulates Microglia, Fractalkine Expression and Neurogenesis in Adult Mice Exposed to Chronic Mild Stress

(2020) Nelly Maritza Vega-Rivera et al.   NEUROSCIENCE

Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic stress-induced depression

(2019) Bojana Stefanovic et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

How do stress, sleep quality, and chronotype associate with clinically significant depressive symptoms? A study of young male military recruits in compulsory service

(2019) André C. Tonon et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

Efficacy and tolerability of pharmacological and non-pharmacological interventions in older patients with major depressive disorder: A systematic review, pairwise and network meta-analysis

(2019) Marc Krause et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The efficacy of melatonin and melatonin agonists in insomnia – An umbrella review

(2019) Tian Ling Low et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Linking the biological underpinnings of depression: Role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition

(2018) George Anderson   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial

(2018) Tracey L. Sletten et al.   PLOS MEDICINE

MELATONIN AS A HORMONE: NEW PHYSIOLOGICAL AND CLINICAL INSIGHTS

(2018) José Cipolla-Neto et al.   ENDOCRINE REVIEWS

Rhythmicity of Mood Symptoms in Individuals at Risk for Psychiatric Disorders

(2018) Luísa K. Pilz et al.   Scientific Reports

Circadian rhythms and psychiatric profiles in young adults with unipolar depressive disorders

(2018) Rébecca Robillard et al.   Translational Psychiatry

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

(2017) Yalikun Suofu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysis

(2017) Emma K. Adam et al.   PSYCHONEUROENDOCRINOLOGY

Prevalence of Circadian Misalignment and Its Association With Depressive Symptoms in Delayed Sleep Phase Disorder

(2017)   SLEEP

Genetic Disruption of Circadian Rhythms in the Suprachiasmatic Nucleus Causes Helplessness, Behavioral Despair, and Anxiety-like Behavior in Mice

(2016) Dominic Landgraf et al.   BIOLOGICAL PSYCHIATRY

Update on melatonin receptors: IUPHAR Review 20

(2016) Ralf Jockers et al.   BRITISH JOURNAL OF PHARMACOLOGY

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder

(2016) Sidney H. Kennedy et al.   CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE

The Circadian Clock and Human Health

(2016) Till Roenneberg et al.   CURRENT BIOLOGY

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Theo Vos et al.   LANCET

Melatonin and neurotrophins NT-3, BDNF, NGF in patients with varying levels of depression severity

(2016) Ewa A. Ogłodek et al.   Pharmacological Reports

Salivary Melatonin in Relation to Depressive Symptom Severity in Young Adults

(2016) Isak Sundberg et al.   PLoS One

Circadian physiology of metabolism

(2016) Satchidananda Panda   SCIENCE

Melatonin receptor activation increases glutamatergic synaptic transmission in the rat medial lateral habenula

(2016) Katherine M. Evely et al.   SYNAPSE

Biomarker approaches in major depressive disorder evaluated in the context of current hypotheses

(2015) Mike C Jentsch et al.   Biomarkers in Medicine

Depression sum-scores don’t add up: why analyzing specific depression symptoms is essential

(2015) Eiko I Fried et al.   BMC Medicine

Current role of melatonin in pediatric neurology: Clinical recommendations

(2015) Oliviero Bruni et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Clinical Practice Guideline for the Treatment of Intrinsic Circadian Rhythm Sleep-Wake Disorders: Advanced Sleep-Wake Phase Disorder (ASWPD), Delayed Sleep-Wake Phase Disorder (DSWPD), Non-24-Hour Sleep-Wake Rhythm Disorder (N24SWD), and Irregular Sleep-Wake Rhythm Disorder (ISWRD). An Update for 2015

(2015) R. Robert Auger et al.   Journal of Clinical Sleep Medicine

Effect of Melatonin on Glutamate: BDNF Signaling in the Cerebral Cortex of Polychlorinated Biphenyls (PCBs)—Exposed Adult Male Rats

(2015) S. Bavithra et al.   NEUROCHEMICAL RESEARCH

Hypothalamic dopaminergic neurons in an animal model of seasonal affective disorder

(2015) Sean P. Deats et al.   NEUROSCIENCE LETTERS

PATHOPHYSIOLOGY OF DEPRESSION: DO WE HAVE ANY SOLID EVIDENCE OF INTEREST TO CLINICIANS?

(2015) GREGOR HASLER   World Psychiatry

Delivery of pineal melatonin to the brain and SCN: role of canaliculi, cerebrospinal fluid, tanycytes and Virchow–Robin perivascular spaces

(2014) Russel J. Reiter et al.   Brain Structure & Function

Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder

(2014) Andras David Nagy et al.   CHRONOBIOLOGY INTERNATIONAL

Oxidative/Nitrosative Stress and Immuno-inflammatory Pathways in Depression: Treatment Implications

(2014) George Anderson et al.   CURRENT PHARMACEUTICAL DESIGN

The therapeutic or prophylactic effect of exogenous melatonin against depression and depressive symptoms: A systematic review and meta-analysis

(2014) M.V. Hansen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The internal time-giver role of melatonin. A key for our health

(2014) P. Pévet   REVUE NEUROLOGIQUE

Disruption of circadian rhythms due to chronic constant light leads to depressive and anxiety-like behaviors in the rat

(2013) Araceli Tapia-Osorio et al.   BEHAVIOURAL BRAIN RESEARCH

Dim light at night increases depressive-like responses in male C3H/HeNHsd mice

(2013) Laura K. Fonken et al.   BEHAVIOURAL BRAIN RESEARCH

The Melatonergic System in Mood and Anxiety Disorders and the Role of Agomelatine: Implications for Clinical Practice

(2013) Domenico De Berardis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders

(2013) Eduardo Ferracioli-Oda et al.   PLoS One

Photoperiodic responses of depression-like behavior, the brain serotonergic system, and peripheral metabolism in laboratory mice

(2013) Tsuyoshi Otsuka et al.   PSYCHONEUROENDOCRINOLOGY

A naturalistic evaluation and audit database of agomelatine: clinical outcome at 12 weeks

(2012) A. Sparshatt et al.   ACTA PSYCHIATRICA SCANDINAVICA

An exploratory study of combination buspirone and melatonin SR in Major Depressive Disorder (MDD): A possible role for neurogenesis in drug discovery

(2012) Maurizio Fava et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Monoamine Theories of Depression: Historical Impact on Biomedical Research

(2012) Shai Mulinari   Journal of the History of the Neurosciences

Aberrant light directly impairs mood and learning through melanopsin-expressing neurons

(2012) Tara A. LeGates et al.   NATURE

Glia-Pinealocyte Network: The Paracrine Modulation of Melatonin Synthesis by Tumor Necrosis Factor (TNF)

(2012) Sanseray da Silveira Cruz-Machado et al.   PLoS One

Neuroimmune endocrine effects of antidepressants

(2012) Livia Carvalho   Neuropsychiatric Disease and Treatment

Circadian-Related Heteromerization of Adrenergic and Dopamine D4 Receptors Modulates Melatonin Synthesis and Release in the Pineal Gland

(2012) Sergio González et al.   PLOS BIOLOGY

6-Sulfatoxymelatonin as a predictor of clinical outcome in depressive patients

(2011) Maria Paz Loayza Hidalgo et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Molecular Basis for Defining the Pineal Gland and Pinealocytes as Targets for Tumor Necrosis Factor

(2011) Claudia Emanuele Carvalho-Sousa et al.   Frontiers in Endocrinology

DAILY VARIATION OF CONSTITUTIVELY ACTIVATED NUCLEAR FACTOR KAPPA B (NFKB) IN RAT PINEAL GLAND

(2010) Erika Cecon et al.   CHRONOBIOLOGY INTERNATIONAL

A randomized double-blind placebo-controlled trial of treatment as usual plus exogenous slow-release melatonin (6 mg) or placebo for sleep disturbance and depressed mood

(2010) Marc Antony Serfaty et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Clinical Implications of the Melatonin Phase Response Curve

(2010) Alfred Lewy   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

TLR4 and CD14 receptors expressed in rat pineal gland trigger NFKB pathway

(2010) Sanseray Da Silveira Cruz-Machado et al.   JOURNAL OF PINEAL RESEARCH

Antidepressant-like effects of melatonin in the mouse chronic mild stress model

(2009) Bernardo C. Detanico et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

It is darkness and not light: Depression-like behaviors of diurnal unstriped Nile grass rats maintained under a short photoperiod schedule

(2009) Tal Ashkenazy-Frolinger et al.   JOURNAL OF NEUROSCIENCE METHODS

Acute increase in urinary 6-sulfatoximelatonin after clomipramine, as a predictive measure for emotional improvement

(2009) RP Markus et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Regulation of Monoamine Oxidase A by Circadian-Clock Components Implies Clock Influence on Mood

(2008) Gabriele Hampp et al.   CURRENT BIOLOGY

Night/Day Changes in Pineal Expression of >600 Genes

(2008) Michael J. Bailey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of antidepressants on melatonin metabolite in depressed patients

(2008) LA Carvalho et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE

Individual Differences in the Amount and Timing of Salivary Melatonin Secretion

(2008) Helen J. Burgess et al.   PLoS One