On inflammatory hypothesis of depression: what is the role of IL-6 in the middle of the chaos?
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
On inflammatory hypothesis of depression: what is the role of IL-6 in the middle of the chaos?
Authors
Keywords
-
Journal
Journal of Neuroinflammation
Volume 18, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-02-18
DOI
10.1186/s12974-021-02100-7
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Variation in chemokines plasma concentrations in primary care depressed patients associated with Internet-based cognitive-behavioral therapy
- (2020) Pablo Romero-Sanchiz et al. Scientific Reports
- Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: A mixed-method study
- (2020) Qian Guo et al. BRAIN BEHAVIOR AND IMMUNITY
- IL-6: Relevance for immunopathology of SARS-CoV-2
- (2020) E.O. Gubernatorova et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Role of Interleukin-6 in Depressive Disorder
- (2020) Emily Yi-Chih Ting et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cytokine release syndrome in severe COVID-19
- (2020) John B. Moore et al. SCIENCE
- Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors
- (2020) Mario Gennaro Mazza et al. BRAIN BEHAVIOR AND IMMUNITY
- Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?
- (2020) Bingwen Liu et al. JOURNAL OF AUTOIMMUNITY
- Epidemic of COVID-19 in China and associated Psychological Problems
- (2020) Md Zahir Ahmed et al. Asian Journal of Psychiatry
- Serum levels of chemokines in adolescents with major depression treated with fluoxetine
- (2020) Francisco Rafael de la Peña et al. World Journal of Psychiatry
- Interleukin‐6 in Covid‐19: A systematic review and meta‐analysis
- (2020) Eric A. Coomes et al. REVIEWS IN MEDICAL VIROLOGY
- Inflammation and posttraumatic stress disorder
- (2019) Hiroaki Hori et al. PSYCHIATRY AND CLINICAL NEUROSCIENCES
- Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response
- (2019) Anne Baudry et al. Frontiers in Neuroscience
- The Role of Chemokines in the Pathophysiology of Major Depressive Disorder
- (2019) Vladimir M. Milenkovic et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Role of inflammation in depression relapse
- (2019) Chun-Hong Liu et al. Journal of Neuroinflammation
- Systematic Review of Gut Microbiota and Major Depression
- (2019) Stephanie G. Cheung et al. Frontiers in Psychiatry
- Cytokine Research in Depression: Principles, Challenges, and Open Questions
- (2019) Hubertus Himmerich et al. Frontiers in Psychiatry
- Systematic review and meta-analysis of the association between peripheral inflammatory cytokines and generalised anxiety disorder
- (2019) Harry Costello et al. BMJ Open
- The Role of Inflammation in Depression and Fatigue
- (2019) Chieh-Hsin Lee et al. Frontiers in Immunology
- Changes in the global burden of depression from 1990 to 2017: Findings from the Global Burden of Disease study
- (2019) Qingqing Liu et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Effects of immunomodulatory drugs on depressive symptoms: A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders
- (2019) Gayle M. Wittenberg et al. MOLECULAR PSYCHIATRY
- Pharmacological Treatment of Depression in Alzheimer’s Disease: A Challenging Task
- (2019) Tommaso Cassano et al. Frontiers in Pharmacology
- Efficacy and safety of monotherapy with sirukumab compared with adalimumab monotherapy in biologic-naïve patients with active rheumatoid arthritis (SIRROUND-H): a randomised, double-blind, parallel-group, multinational, 52-week, phase 3 study
- (2018) Peter C Taylor et al. ANNALS OF THE RHEUMATIC DISEASES
- Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study
- (2018) Sophie E. Holmes et al. BIOLOGICAL PSYCHIATRY
- Interleukin, tumor necrosis factor-α and C-reactive protein profiles in melancholic and non-melancholic depression: A systematic review
- (2018) Chenghao Yang et al. JOURNAL OF PSYCHOSOMATIC RESEARCH
- Changes in the serum levels of inflammatory cytokines in antidepressant drug-naïve patients with major depression
- (2018) Wei Zou et al. PLoS One
- Translocator protein (18 kDa TSPO) binding, a marker of microglia, is reduced in major depression during cognitive-behavioral therapy
- (2018) Hua Li et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Physiological effects of modulating the interleukin-6 axis
- (2018) Georg Schett RHEUMATOLOGY
- Relationship between interleukin (IL)-6 and brain morphology in drug-naïve, first-episode major depressive disorder using surface-based morphometry
- (2018) Shingo Kakeda et al. Scientific Reports
- PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects
- (2018) Erica M. Richards et al. EJNMMI Research
- The association between anxiety, traumatic stress, and obsessive-compulsive disorders and chronic inflammation: A systematic review and meta-analysis
- (2018) Megan E. Renna et al. DEPRESSION AND ANXIETY
- Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition
- (2018) Silvia Diviccaro et al. PSYCHONEUROENDOCRINOLOGY
- Safety of tocilizumab in the treatment of juvenile idiopathic arthritis
- (2017) Sandra Helena Machado et al. Expert Opinion On Drug Safety
- Altered serum levels of TNF-α, IL-6, and IL-18 in depressive disorder patients
- (2017) Ni Fan et al. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
- Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy
- (2017) Paula Kopschina Feltes et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis
- (2017) S P Leighton et al. MOLECULAR PSYCHIATRY
- Interactions between the microbiota, immune and nervous systems in health and disease
- (2017) Thomas C Fung et al. NATURE NEUROSCIENCE
- Neural basis of major depressive disorder: Beyond monoamine hypothesis
- (2017) Shuken Boku et al. PSYCHIATRY AND CLINICAL NEUROSCIENCES
- Blockade of interleukin-6 receptor in the periphery promotes rapid and sustained antidepressant actions: a possible role of gut–microbiota–brain axis
- (2017) J-c Zhang et al. Translational Psychiatry
- Mood Therapeutics: Novel Pharmacological Approaches for Treating Depression
- (2017) Ioline D. Henter et al. Expert Review of Clinical Pharmacology
- The Modulatory Properties of Chronic Antidepressant Drugs Treatment on the Brain Chemokine – Chemokine Receptor Network: A Molecular Study in an Animal Model of Depression
- (2017) Ewa Trojan et al. Frontiers in Pharmacology
- Sirukumab: A Potential Treatment for Mood Disorders?
- (2016) Aileen J. Zhou et al. ADVANCES IN THERAPY
- Brain-gut-microbiota axis: challenges for translation in psychiatry
- (2016) John R. Kelly et al. ANNALS OF EPIDEMIOLOGY
- The role of interleukin-6 signaling in nervous tissue
- (2016) Michelle Rothaug et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity
- (2016) Melanie Schirmer et al. CELL
- The Central Nervous System and the Gut Microbiome
- (2016) Gil Sharon et al. CELL
- A Potential Contribution of Chemokine Network Dysfunction to the Depressive Disorders
- (2016) Joanna |lusarczyk et al. Current Neuropharmacology
- Tocilizumab for treating juvenile idiopathic arthritis
- (2016) Jessica L. Turnier et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- The clinical effectiveness and cost-effectiveness of abatacept, adalimumab, etanercept and tocilizumab for treating juvenile idiopathic arthritis: a systematic review and economic evaluation
- (2016) Jonathan Shepherd et al. HEALTH TECHNOLOGY ASSESSMENT
- Alteration of immune markers in a group of melancholic depressed patients and their response to electroconvulsive therapy
- (2016) Gavin Rush et al. JOURNAL OF AFFECTIVE DISORDERS
- Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism
- (2016) P Zheng et al. MOLECULAR PSYCHIATRY
- A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression
- (2016) D R Goldsmith et al. MOLECULAR PSYCHIATRY
- Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions
- (2016) N Kappelmann et al. MOLECULAR PSYCHIATRY
- Integrating neuroimmune systems in the neurobiology of depression
- (2016) Eric S. Wohleb et al. NATURE REVIEWS NEUROSCIENCE
- Effects of interleukin-6, interleukin-18, and statin use, evaluated at acute stroke, on post-stroke depression during 1-year follow-up
- (2016) Hee-Ju Kang et al. PSYCHONEUROENDOCRINOLOGY
- Gut microbiota role in irritable bowel syndrome: New therapeutic strategies
- (2016) Eleonora Distrutti et al. WORLD JOURNAL OF GASTROENTEROLOGY
- The healthy human microbiome
- (2016) Jason Lloyd-Price et al. Genome Medicine
- Peripheral interleukin-6 promotes resilience versus susceptibility to inescapable electric stress
- (2015) Chun Yang et al. ACTA NEUROPSYCHIATRICA
- Neuroimmune and neuroendocrine abnormalities in depression: two sides of the same coin
- (2015) Mark A. Horowitz et al. Annals of the New York Academy of Sciences
- The complex contribution of chemokines to neuroinflammation: switching from beneficial to detrimental effects
- (2015) Ophélia Le Thuc et al. Annals of the New York Academy of Sciences
- Tocilizumab in early progressive rheumatoid arthritis: FUNCTION, a randomised controlled trial
- (2015) Gerd R Burmester et al. ANNALS OF THE RHEUMATIC DISEASES
- Why Sleep Is Important for Health: A Psychoneuroimmunology Perspective
- (2015) Michael R. Irwin Annual Review of Psychology
- Meta-Analysis of Cytokines and Chemokines in Suicidality: Distinguishing Suicidal Versus Nonsuicidal Patients
- (2015) Carmen Black et al. BIOLOGICAL PSYCHIATRY
- Altered fecal microbiota composition in patients with major depressive disorder
- (2015) Haiyin Jiang et al. BRAIN BEHAVIOR AND IMMUNITY
- Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder
- (2015) Rita Haapakoski et al. BRAIN BEHAVIOR AND IMMUNITY
- Inflammation and clinical response to treatment in depression: A meta-analysis
- (2015) R. Strawbridge et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Novel investigational drugs targeting IL-6 signaling for the treatment of depression
- (2015) Trehani M Fonseka et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Peripheral IL-6 signaling: a promising therapeutic target for depression?
- (2015) Chun Yang et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Prevention of Relapse and Recurrence in Adults with Major Depressive Disorder: Systematic Review and Meta-Analyses of Controlled Trials
- (2015) Kang Sim et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- IL-6 as a keystone cytokine in health and disease
- (2015) Christopher A Hunter et al. NATURE IMMUNOLOGY
- What has serotonin to do with depression?
- (2015) Philip J. Cowen et al. World Psychiatry
- Prenatal stress is a vulnerability factor for altered morphology and biological activity of microglia cells
- (2015) Joanna Ślusarczyk et al. Frontiers in Cellular Neuroscience
- STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior
- (2015) Eryan Kong et al. Scientific Reports
- Peripheral interleukin-6 promotes resilience versus susceptibility to inescapable electric stress
- (2015) Chun Yang et al. ACTA NEUROPSYCHIATRICA
- Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes
- (2015) Elaine Setiawan et al. JAMA Psychiatry
- Weight Gain and Metabolic Changes During Treatment with Antipsychotics and Antidepressants
- (2015) Hubertus Himmerich et al. Endocrine Metabolic & Immune Disorders-Drug Targets
- Inflammatory Cytokines in General and Central Obesity and Modulating Effects of Physical Activity
- (2015) Frank M. Schmidt et al. PLoS One
- Ingested (oral) tocilizumab inhibits EAE
- (2014) Staley A. Brod et al. CYTOKINE
- Interleukin-6 and its receptors: A highly regulated and dynamic system
- (2014) Janina Wolf et al. CYTOKINE
- The good, the bad, and the ugly of interleukin-6 signaling
- (2014) J. J. Fuster et al. EMBO JOURNAL
- Network dynamics determine the autocrine and paracrine signaling functions of TNF
- (2014) Andrew B. Caldwell et al. GENES & DEVELOPMENT
- A review of the relationship between proinflammatory cytokines and major depressive disorder
- (2014) Juan Joseph Young et al. JOURNAL OF AFFECTIVE DISORDERS
- C-reactive protein, interleukin-6, soluble tumor necrosis factor α receptor 2 and incident clinical depression
- (2014) Patricia O. Chocano-Bedoya et al. JOURNAL OF AFFECTIVE DISORDERS
- Prädiktive Faktoren der Depression und ihrer Therapie
- (2014) H. Himmerich et al. NERVENARZT
- Chemokines and chemokine receptors in mood disorders, schizophrenia, and cognitive impairment: A systematic review of biomarker studies
- (2014) M.J. Stuart et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress
- (2014) Georgia E. Hodes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural biology of the IL-1 superfamily: Key cytokines in the regulation of immune and inflammatory responses
- (2014) Brian Krumm et al. PROTEIN SCIENCE
- Elevated IL-6 levels in patients with atypical depression but not in patients with typical depression
- (2014) Sebastian Rudolf et al. PSYCHIATRY RESEARCH
- From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.
- (2014) George M. Slavich et al. PSYCHOLOGICAL BULLETIN
- Association of Serum Interleukin 6 and C-Reactive Protein in Childhood With Depression and Psychosis in Young Adult Life
- (2014) Golam M. Khandaker et al. JAMA Psychiatry
- CYTOKINE TARGETS IN THE BRAIN: IMPACT ON NEUROTRANSMITTERS AND NEUROCIRCUITS
- (2013) Andrew H. Miller et al. DEPRESSION AND ANXIETY
- Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder
- (2013) Daimei Sasayama et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Noradrenaline acting on astrocytic β2-adrenoceptors induces neurite outgrowth in primary cortical neurons
- (2013) Jennifer S. Day et al. NEUROPHARMACOLOGY
- Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications
- (2013) J.C. Felger et al. NEUROSCIENCE
- Increased abundance of Sutterella spp. and Ruminococcus torques in feces of children with autism spectrum disorder
- (2013) Lv Wang et al. Molecular Autism
- Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ
- (2013) Caitriona M. Guinane et al. Therapeutic Advances in Gastroenterology
- Tocilizumab in rheumatoid arthritis: efficacy, safety and its place in therapy
- (2013) Atsushi Kaneko Therapeutic Advances in Chronic Disease
- Is unpredictable chronic mild stress (UCMS) a reliable model to study depression-induced neuroinflammation?
- (2012) Rai Khalid Farooq et al. BEHAVIOURAL BRAIN RESEARCH
- The Chemokine Superfamily Revisited
- (2012) Albert Zlotnik et al. IMMUNITY
- Effects of fluoxetine, tianeptine and olanzapine on unpredictable chronic mild stress-induced depression-like behavior in mice
- (2012) Oguz Mutlu et al. LIFE SCIENCES
- Neurobiology of resilience
- (2012) Scott J Russo et al. NATURE NEUROSCIENCE
- The neurobiology of depression--revisiting the serotonin hypothesis. I. Cellular and molecular mechanisms
- (2012) P. R. Albert et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Beyond the monoaminergic hypothesis: neuroplasticity and epigenetic changes in a transgenic mouse model of depression
- (2012) R. Massart et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Anti-inflammatory treatment in schizophrenia
- (2012) Norbert Müller et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Application of Novel PCR-Based Methods for Detection, Quantitation, and Phylogenetic Characterization of Sutterella Species in Intestinal Biopsy Samples from Children with Autism and Gastrointestinal Disturbances
- (2012) B. L. Williams et al. mBio
- Systematic Review of Proinflammatory Cytokines in Obsessive-Compulsive Disorder
- (2012) Simon M. Gray et al. Current Psychiatry Reports
- Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder
- (2012) T Frodl et al. Translational Psychiatry
- Efficacy of tocilizumab in patients with moderate to severe active rheumatoid arthritis and a previous inadequate response to disease-modifying antirheumatic drugs: the ROSE study
- (2011) Yusuf Yazici et al. ANNALS OF THE RHEUMATIC DISEASES
- The pro- and anti-inflammatory properties of the cytokine interleukin-6
- (2011) Jürgen Scheller et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Interleukin-6, a mental cytokine
- (2011) Anneleen Spooren et al. BRAIN RESEARCH REVIEWS
- Cytokines and brain excitability
- (2011) Michael A. Galic et al. FRONTIERS IN NEUROENDOCRINOLOGY
- An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
- (2011) Ian B Jeffery et al. GUT
- Functional Specialization of Interleukin-17 Family Members
- (2011) Yoichiro Iwakura et al. IMMUNITY
- Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: A meta-analysis and meta-regression
- (2011) Yang Liu et al. JOURNAL OF AFFECTIVE DISORDERS
- Constant Darkness Induces IL-6-Dependent Depression-Like Behavior through the NF- B Signaling Pathway
- (2011) F. J. Monje et al. JOURNAL OF NEUROSCIENCE
- Immune system to brain signaling: Neuropsychopharmacological implications
- (2011) Lucile Capuron et al. PHARMACOLOGY & THERAPEUTICS
- Is Depression an Inflammatory Disorder?
- (2011) Charles L. Raison et al. Current Psychiatry Reports
- Prevention of Major Depression
- (2010) Ricardo F. Muñoz et al. Annual Review of Clinical Psychology
- IL-6: Regulator of Treg/Th17 balance
- (2010) Akihiro Kimura et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Statins potently reduce the cytokine-mediated IL-6 release in SMC/MNC cocultures
- (2010) Harald Loppnow et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Enhanced Th17 phenotype in individuals with generalized anxiety disorder
- (2010) Morgana M.M. Vieira et al. JOURNAL OF NEUROIMMUNOLOGY
- Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
- (2009) Andrew H. Miller et al. BIOLOGICAL PSYCHIATRY
- A Meta-Analysis of Cytokines in Major Depression
- (2009) Yekta Dowlati et al. BIOLOGICAL PSYCHIATRY
- The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age
- (2009) D Mariat et al. BMC MICROBIOLOGY
- A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder
- (2009) Rushaniya A. Khairova et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Monocyte Chemoattractant Protein-1 (MCP-1): An Overview
- (2009) Satish L. Deshmane et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis
- (2009) M Bryant Howren et al. PSYCHOSOMATIC MEDICINE
- Pro-inflammatory biomakers in depression: Treatment with venlafaxine
- (2009) John E. Piletz et al. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
- Depressive Symptoms and Metabolic Syndrome: Is Inflammation the Underlying Link?
- (2008) Lucile Capuron et al. BIOLOGICAL PSYCHIATRY
- C-Reactive Protein is Linked to Lower Cognitive Performance in Overweight and Obese Women
- (2008) V. Sweat et al. INFLAMMATION
- CSF and plasma cytokines at delivery and postpartum mood disturbances
- (2008) Fotini Boufidou et al. JOURNAL OF AFFECTIVE DISORDERS
- A detailed examination of cytokine abnormalities in Major Depressive Disorder
- (2007) N.M. Simon et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started