AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability

Autophagy and endocytosis – interconnections and interdependencies

(2020) Åsa B. Birgisdottir et al.   JOURNAL OF CELL SCIENCE

Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice

(2020) Preeti Raju et al.   JOURNAL OF CLINICAL INVESTIGATION

The Crohn’s disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response

(2019) Sydney Lavoie et al.   eLife

Intestinal Epithelial Tight Junction Barrier regulation by Autophagy related protein ATG6/beclin 1

(2019) Morgan Wong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

(2017) Elena Bekerman et al.   JOURNAL OF CLINICAL INVESTIGATION

NBR1 enables autophagy-dependent focal adhesion turnover

(2016) Candia M. Kenific et al.   JOURNAL OF CELL BIOLOGY

Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis

(2016) Xiaoting Wu et al.   Nature Communications

Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8 + T Cell Responses

(2016) Monica Loi et al.   Cell Reports

Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition

(2016) Dohyun Park et al.   Scientific Reports

Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis

(2015) Prashant Nighot et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Clathrin-dependent endocytosis of claudin-2 by DFYSP peptide causes lysosomal damage in lung adenocarcinoma A549 cells

(2015) Akira Ikari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Autophagy Enhances Intestinal Epithelial Tight Junction Barrier Function by Targeting Claudin-2 Protein Degradation

(2015) Prashant K. Nighot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Protects against Colitis by the Maintenance of Normal Gut Microflora and Secretion of Mucus

(2015) Koichiro Tsuboi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AP-2-Associated Protein Kinase 1 and Cyclin G-Associated Kinase Regulate Hepatitis C Virus Entry and Are Potential Drug Targets

(2015) Gregory Neveu et al.   JOURNAL OF VIROLOGY

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy

(2014) D. Popovic et al.   EMBO REPORTS

Rab14 regulation of claudin-2 trafficking modulates epithelial permeability and lumen morphogenesis

(2014) Ruifeng Lu et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endocytosis and Autophagy: Exploitation or Cooperation?

(2014) S. A. Tooze et al.   Cold Spring Harbor Perspectives in Biology

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy

(2013) Y. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes

(2012) Andrea Longatti et al.   JOURNAL OF CELL BIOLOGY

Impaired autophagy leads to abnormal dendritic cell–epithelial cell interactions

(2012) Caterina Strisciuglio et al.   Journal of Crohns & Colitis

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

The PIKfyve Inhibitor YM201636 Blocks the Continuous Recycling of the Tight Junction Proteins Claudin-1 and Claudin-2 in MDCK cells

(2012) Joseph D. Dukes et al.   PLoS One

Chloride channel ClC-2 modulates tight junction barrier function via intracellular trafficking of occludin

(2011) Prashant K. Nighot et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Autophagosome Precursor Maturation Requires Homotypic Fusion

(2011) Kevin Moreau et al.   CELL

Interleukin-6 (IL-6) Regulates Claudin-2 Expression and Tight Junction Permeability in Intestinal Epithelium

(2011) Takuya Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis

(2011) Stephen J. Terry et al.   NATURE CELL BIOLOGY

Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation

(2011) P Dhawan et al.   ONCOGENE

Claudin-2 Forms Homodimers and Is a Component of a High Molecular Weight Protein Complex

(2010) Christina M. Van Itallie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases

(2010) Maurizio Renna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

(2010) Mirkka Koivusalo et al.   JOURNAL OF CELL BIOLOGY

Epidermal growth factor increases clathrin-dependent endocytosis and degradation of claudin-2 protein in MDCK II cells

(2010) Akira Ikari et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy

(2010) Molly A. Lynch-Day et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNFα up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling

(2009) J. Mankertz et al.   CELL AND TISSUE RESEARCH

Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin

(2009) Jae-Min Yuk et al.   Cell Host & Microbe

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

The density of small tight junction pores varies among cell types and is increased by expression of claudin-2

(2008) C. M. Van Itallie et al.   JOURNAL OF CELL SCIENCE

Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation

(2008) Christopher R Weber et al.   LABORATORY INVESTIGATION

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

(2008) Chengyu Liang et al.   NATURE CELL BIOLOGY