Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice

Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability

(2019) Sam C. Nalle et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibiting casein kinase 2 overcomes paclitaxel resistance in gastric cancer

(2019) Minkyu Jung et al.   Gastric Cancer

Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis

(2019) W. Vallen Graham et al.   NATURE MEDICINE

Claudin‐15 forms a water channel through the tight junction with distinct function compared to claudin‐2

(2019) Rita Rosenthal et al.   Acta Physiologica

Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease

(2019) M. Lora D. M. Ong et al.   LABORATORY INVESTIGATION

Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis

(2018) Deepika Sharma et al.   GASTROENTEROLOGY

Sodium chloride exacerbates dextran sulfate sodium-induced colitis by tuning proinflammatory and antiinflammatory lamina propria mononuclear cells through p38/MAPK pathway in mice

(2018) Hong-Xia Guo et al.   WORLD JOURNAL OF GASTROENTEROLOGY

A phase IB study of CX-4945 in combination with gemcitabine plus cisplatin in the frontline systemic treatment of patients with advanced cholangiocarcinoma.

(2017) Mitesh J. Borad et al.   JOURNAL OF CLINICAL ONCOLOGY

Findings from the phase I clinical trials of CX-4945, an orally available inhibitor of CK2.

(2017) R. F. Marschke et al.   JOURNAL OF CLINICAL ONCOLOGY

A refined model of claudin-15 tight junction paracellular architecture by molecular dynamics simulations

(2017) Giulio Alberini et al.   PLoS One

Claudin-2-mediated cation and water transport share a common pore

(2016) R. Rosenthal et al.   Acta Physiologica

Paracellular epithelial sodium transport maximizes energy efficiency in the kidney

(2016) Lei Pei et al.   JOURNAL OF CLINICAL INVESTIGATION

Separation of intact intestinal epithelium from mesenchyme

(2016) Ali Moussavi Nik et al.   BIOTECHNIQUES

Sex-related differences in small intestinal transit and serotonin dynamics in high-fat-diet-induced obesity in mice

(2015) Marion France et al.   EXPERIMENTAL PHYSIOLOGY

Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells

(2015) Amanda L. Hernandez et al.   JOURNAL OF CLINICAL INVESTIGATION

Adrenomedullin improves intestinal epithelial barrier function by downregulating myosin light chain phosphorylation in ulcerative colitis rats

(2015) ZAIFENG YI et al.   Molecular Medicine Reports

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Claudin-2-dependent paracellular channels are dynamically gated

(2015) Christopher R Weber et al.   eLife

Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression and protects from colitis

(2014) R Ahmad et al.   Mucosal Immunology

Myosin Light Chain Kinase Expression Induced via Tumor Necrosis Factor Receptor 2 Signaling in the Epithelial Cells Regulates the Development of Colitis-Associated Carcinogenesis

(2014) Masahiro Suzuki et al.   PLoS One

Claudin-2 pore function requires an intramolecular disulfide bond between two conserved extracellular cysteines

(2013) Jiahua Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

CK2-dependent phosphorylation of occludin regulates the interaction with ZO-proteins and tight junction integrity

(2013) Max J Dörfel et al.   Cell Communication and Signaling

Claudin-2 Regulates Colorectal Inflammation via Myosin Light Chain Kinase-Dependent Signaling

(2013) Masayuki Nishida et al.   DIGESTIVE DISEASES AND SCIENCES

TNFR2 Activates MLCK-Dependent Tight Junction Dysregulation to Cause Apoptosis-Mediated Barrier Loss and Experimental Colitis

(2013) Liping Su et al.   GASTROENTEROLOGY

Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia

(2013) L R Martins et al.   LEUKEMIA

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

(2013) Chuan Wu et al.   NATURE

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

(2013) Markus Kleinewietfeld et al.   NATURE

Claudins and the Modulation of Tight Junction Permeability

(2013) Dorothee Günzel et al.   PHYSIOLOGICAL REVIEWS

Defective tight junctions in refractory celiac disease

(2012) Michael Schumann et al.   Annals of the New York Academy of Sciences

Charge-selective claudin channels

(2012) Susanne M. Krug et al.   Annals of the New York Academy of Sciences

Claudins and the Kidney

(2012) Jianghui Hou et al.   Annual Review of Physiology

Loss of Claudins 2 and 15 From Mice Causes Defects in Paracellular Na+ Flow and Nutrient Transport in Gut and Leads to Death from Malnutrition

(2012) Masami Wada et al.   GASTROENTEROLOGY

Protein kinase CK2 is a critical regulator of epithelial homeostasis in chronic intestinal inflammation

(2012) S Koch et al.   Mucosal Immunology

Tight Junction Pore and Leak Pathways: A Dynamic Duo

(2011) Le Shen et al.   Annual Review of Physiology

Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function

(2011) David R. Raleigh et al.   JOURNAL OF CELL BIOLOGY

CX-4945, an Orally Bioavailable Selective Inhibitor of Protein Kinase CK2, Inhibits Prosurvival and Angiogenic Signaling and Exhibits Antitumor Efficacy

(2010) A. Siddiqui-Jain et al.   CANCER RESEARCH

Structural basis of CX-4945 binding to human protein kinase CK2

(2010) Andrew D. Ferguson et al.   FEBS LETTERS

Loss of Claudin-15, but Not Claudin-2, Causes Na+ Deficiency and Glucose Malabsorption in Mouse Small Intestine

(2010) Atsushi Tamura et al.   GASTROENTEROLOGY

Epithelial Myosin Light Chain Kinase Activation Induces Mucosal Interleukin-13 Expression to Alter Tight Junction Ion Selectivity

(2010) Christopher R. Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Claudin-2, a component of the tight junction, forms a paracellular water channel

(2010) R. Rosenthal et al.   JOURNAL OF CELL SCIENCE

Claudin-2–deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules

(2010) Shigeaki Muto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Function Studies of Claudin Extracellular Domains by Cysteine-scanning Mutagenesis

(2009) Susanne Angelow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

Unique Role of Junctional Adhesion Molecule-A in Maintaining Mucosal Homeostasis in Inflammatory Bowel Disease

(2008) Stefania Vetrano et al.   GASTROENTEROLOGY

The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state

(2008) Le Shen et al.   JOURNAL OF CELL BIOLOGY

The density of small tight junction pores varies among cell types and is increased by expression of claudin-2

(2008) C. M. Van Itallie et al.   JOURNAL OF CELL SCIENCE

Molecular Basis for Cation Selectivity in Claudin-2–based Paracellular Pores: Identification of an Electrostatic Interaction Site

(2008) Alan S.L. Yu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation

(2008) Christopher R Weber et al.   LABORATORY INVESTIGATION

Megaintestine in Claudin-15–Deficient Mice

(2007) Atsushi Tamura et al.   GASTROENTEROLOGY