Insulin resistance in glomerular podocytes: Potential mechanisms of induction

Involvement of nitric oxide synthase/nitric oxide pathway in the regulation of SIRT1–AMPK crosstalk in podocytes: Impact on glucose uptake

(2021) Dorota Rogacka et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Resveratrol ameliorates renal damage by inhibiting oxidative stress-mediated apoptosis of podocytes in diabetic nephropathy

(2020) Fang Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Saturated fatty acids induce insulin resistance in podocytes through inhibition of IRS1 via activation of both IKKβ and mTORC1

(2020) Benoit Denhez et al.   Scientific Reports

Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice

(2019) Liming Wang et al.   KIDNEY INTERNATIONAL

Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics

(2019) Paul T. Brinkkoetter et al.   Cell Reports

SMPDL3b modulates insulin receptor signaling in diabetic kidney disease

(2019) A. Mitrofanova et al.   Nature Communications

Metformin reduces TRPC6 expression through AMPK activation and modulates cytoskeleton dynamics in podocytes under diabetic conditions

(2019) Maria Szrejder et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK

(2018) Dorota Rogacka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Urine markers of podocyte dysfunction: a review of podocalyxin and nephrin in selected glomerular diseases

(2018) Gilbert Akankwasa et al.   Biomarkers in Medicine

A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease

(2018) Daria V. Ilatovskaya et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress

(2018) Kathryn L. Garner et al.   Scientific Reports

Angiotensin II Modulates Podocyte Glucose Transport

(2018) Barbara Lewko et al.   Frontiers in Endocrinology

Palmitate induces mitochondrial superoxide generation and activates AMPK in podocytes

(2017) Eugene Lee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Protein tyrosine phosphatase 1B deficiency in podocytes mitigates hyperglycemia-induced renal injury

(2017) Yoshihiro Ito et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

O-linked β-N-acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes

(2017) Shinya Ono et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mechanistic Insight and Management of Diabetic Nephropathy: Recent Progress and Future Perspective

(2017) Rui Xue et al.   Journal of Diabetes Research

Structural Predictors of Loss of Renal Function in American Indians with Type 2 Diabetes

(2016) G. D. Fufaa et al.   Clinical Journal of the American Society of Nephrology

Persistent Insulin Resistance in Podocytes Caused by Epigenetic Changes of SHP-1 in Diabetes

(2016) Farah Lizotte et al.   DIABETES

SIRT1-AMPK crosstalk is involved in high glucose-dependent impairment of insulin responsiveness in primary rat podocytes

(2016) Dorota Rogacka et al.   EXPERIMENTAL CELL RESEARCH

Intracellular calcium signaling regulates glomerular filtration barrier permeability: the role of the PKGIα-dependent pathway

(2016) Agnieszka Piwkowska et al.   FEBS LETTERS

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

Sildenafil Prevents Podocyte InjuryviaPPAR-γ–Mediated TRPC6 Inhibition

(2016) Ramon Sonneveld et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Metformin ameliorates podocyte damage by restoring renal tissue nephrin expression in type 2 diabetic rats

(2016) Limin Zhai et al.   Journal of Diabetes

IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes

(2015) Beatriz Santamaria et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microRNA-377

(2015) Wei Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Podocyte-Specific Deletion of Yes-Associated Protein Causes FSGS and Progressive Renal Failure

(2015) M. Schwartzman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Targeting endoplasmic reticulum stress in insulin resistance

(2015) Laia Salvadó et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy

(2015) Thati Madhusudhan et al.   Nature Communications

Metformin Ameliorates Podocyte Damage by Restoring Renal Tissue Podocalyxin Expression in Type 2 Diabetic Rats

(2015) Limin Zhai et al.   Journal of Diabetes Research

CD36 Mediated Fatty Acid-Induced Podocyte Apoptosis via Oxidative Stress

(2015) Wei Hua et al.   PLoS One

Renal Lipotoxicity-Associated Inflammation and Insulin Resistance Affects Actin Cytoskeleton Organization in Podocytes

(2015) Cristina Martínez-García et al.   PLoS One

Ezrin Is Down-Regulated in Diabetic Kidney Glomeruli and Regulates Actin Reorganization and Glucose Uptake via GLUT1 in Cultured Podocytes

(2014) Anita A. Wasik et al.   AMERICAN JOURNAL OF PATHOLOGY

Insulin stimulates glucose transport via protein kinase G type I alpha-dependent pathway in podocytes

(2014) Agnieszka Piwkowska et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Involvement of the AMPK–PTEN pathway in insulin resistance induced by high glucose in cultured rat podocytes

(2014) Dorota Rogacka et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Role of endoplasmic reticulum stress in apoptosis of differentiated mouse podocytes induced by high glucose

(2014) YANPING CAO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cross-talk between Two Essential Nutrient-sensitive Enzymes

(2014) John W. Bullen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased SHP-1 Protein Expression by High Glucose Levels Reduces Nephrin Phosphorylation in Podocytes

(2014) Benoit Denhez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potentiation of neuronal insulin signaling and glucose uptake by resveratrol: the involvement of AMPK

(2014) Mayur I. Patel et al.   Pharmacological Reports

Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

(2014) Julia Szendroedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Importance of Podocyte Adhesion for a Healthy Glomerulus

(2014) Rachel Lennon et al.   Frontiers in Endocrinology

Expression of SHP-1 induced by hyperglycemia prevents insulin actions in podocytes

(2013) Nicolas Drapeau et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Anti-Insulin Receptor Antibodies Related to Hypoglycemia in a Previously Diabetic Patient

(2013) J.-C. Maiza et al.   DIABETES CARE

The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing

(2013) L. Luu et al.   DIABETOLOGIA

High glucose increases glomerular filtration barrier permeability by activating protein kinase G type Iα subunits in a Nox4-dependent manner

(2013) Agnieszka Piwkowska et al.   EXPERIMENTAL CELL RESEARCH

Angiotensin II Activation of TRPC6 Channels in Rat Podocytes Requires Generation of Reactive Oxygen Species

(2013) Marc Anderson et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hydrogen peroxide induces activation of insulin signaling pathway via AMP-dependent kinase in podocytes

(2012) Agnieszka Piwkowska et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction

(2012) Angeliki Chalkiadaki et al.   Cell Metabolism

Redox Signaling in Cardiac Physiology and Pathology

(2012) Joseph R. Burgoyne et al.   CIRCULATION RESEARCH

GLUT4 exocytosis

(2012) Jacqueline Stöckli et al.   JOURNAL OF CELL SCIENCE

Post-translational protein modification by O-linked N-acetyl-glucosamine: Its role in mediating the adverse effects of diabetes on the heart

(2012) Jennifer L. McLarty et al.   LIFE SCIENCES

Adipose tissue renin–angiotensin–aldosterone system (RAAS) and progression of insulin resistance

(2012) Yonit Marcus et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

PI3K signalling: the path to discovery and understanding

(2012) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Receptor-isoform-selective insulin analogues give tissue-preferential effects

(2011) Sara G. Vienberg et al.   BIOCHEMICAL JOURNAL

High glucose concentration affects the oxidant-antioxidant balance in cultured mouse podocytes

(2011) Agnieszka Piwkowska et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hydrogen peroxide induces dimerization of protein kinase G type Iα subunits and increases albumin permeability in cultured rat podocytes

(2011) Agnieszka Piwkowska et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity

(2011) Akira Mima et al.   KIDNEY INTERNATIONAL

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

(2011) Sara Fröjdö et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Alteration of Forkhead Box O (Foxo4) Acetylation Mediates Apoptosis of Podocytes in Diabetes Mellitus

(2011) Peter Y. Chuang et al.   PLoS One

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin induces suppression of NAD(P)H oxidase activity in podocytes

(2010) Agnieszka Piwkowska et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function

(2010) Gavin I. Welsh et al.   Cell Metabolism

Downregulation of the Longevity-Associated Protein Sirtuin 1 in Insulin Resistance and Metabolic Syndrome: Potential Biochemical Mechanisms

(2010) S. V. de Kreutzenberg et al.   DIABETES

SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

(2010) Samuel Caito et al.   FASEB JOURNAL

Oxidative stress, insulin signaling, and diabetes

(2010) Justin L. Rains et al.   FREE RADICAL BIOLOGY AND MEDICINE

Expression of GFAT1 and OGT in podocytes: Transport of glucosamine and the implications for glucose uptake into these cells

(2010) Dorota Rogacka et al.   JOURNAL OF CELLULAR PHYSIOLOGY

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

(2010) S. H. Francis et al.   PHARMACOLOGICAL REVIEWS

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Alterations in Fatty Acid Utilization and an Impaired Antioxidant Defense Mechanism Are Early Events in Podocyte Injury

(2009) Corina Mayrhofer et al.   AMERICAN JOURNAL OF PATHOLOGY

Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

(2009) Jean-François Tanti et al.   CURRENT OPINION IN PHARMACOLOGY

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

(2009) Brooke M. Emerling et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hyperglycemia and mechanical stress: Targeting the renal podocyte

(2009) Barbara Lewko et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Slit Diaphragms Contain Tight Junction Proteins

(2009) H. Fukasawa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Identification of a Distal GLUT4 Trafficking Event Controlled by Actin Polymerization

(2009) Jamie A. Lopez et al.   MOLECULAR BIOLOGY OF THE CELL

The role of transient receptor potential channels in kidney disease

(2009) Titia E. Woudenberg-Vrenken et al.   Nature Reviews Nephrology

Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy

(2009) R. Lennon et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Epithelial-to-Mesenchymal Transition Is a Potential Pathway Leading to Podocyte Dysfunction and Proteinuria

(2008) Yingjian Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Ca2+ and insulin-mediated glucose uptake

(2008) J LANNER et al.   CURRENT OPINION IN PHARMACOLOGY

Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes

(2008) J. M. Forbes et al.   DIABETES

Nitric oxide-cGMP-protein kinase G pathway negatively regulates vascular transient receptor potential channel TRPC6

(2008) Shinichi Takahashi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sensitizing the Slit Diaphragm with TRPC6 Ion Channels

(2008) C. C. Moller et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Failure to phosphorylate AKT in podocytes from mice with early diabetic nephropathy promotes cell death

(2008) T. Tejada et al.   KIDNEY INTERNATIONAL